Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Can a heterozygous allele show non-heterozygous expression in a family?

I'm doing a family study looking for novel cancer-associated variants in germ-line samples; the goal is to find candidate biomarkers which might be used for early detection. At an earlier step our ...
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115 views

What is doubling of genetic material invented in flowering plants?

David Attenborough in his Kingdom of Plants 3D said, that flowering plants made two inventions: (1) doubling of genetic material and (2) symbiosis with animals. What was meant by "doubling of genetic ...
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861 views

what is the difference between “cistron” and “gene”

I'm asking after reading the cognate wikipedia.en article on "cistron". I still am not sure about the difference of the two terms. To me it seems valid to picture a "cistron" as the genome wide set ...
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84 views

Pedigree analysis : autosomal or mitochondrial

I have tried a to decide if this is a autosomal dominant, recessive or a mitochondrial disorder. Is it possible to know for sure, or do you have to use probability? (English is not my native ...
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619 views

Do trees age on a microscopic level?

Most animals age via at least two mechinisms: at a "macroscopic" level, basically wear and tear to the point where (on evolutionary time scales) it's more genetically advantageous to optimize for ...
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Valid comparison of gene expression between several genes in several cell lines

We have gene expression data (Affimetrix mRNA gene expression results) for several cell lines, over a set of genes. Our goal would be to be able to compare relative gene expression for genes over the ...
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129 views

Can someone who is color blind recover color vision by surgical means?

I am currently studying color blindness, and there is no medicine that can help it. Is it possible nonetheless for someone who is color blind to have their eyes restored to normal color vision by ...
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23 views

Primers on Dystonia

Where can I get a good biochemical overview of dystonia? I will be working in a research lab that focuses on dystonia and I would like to not be clueless.
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56 views

Mode of inheritance - DYT1 Dystonia

Homozygous DYT1 mutation carriers have not been reported in humans. Does this mean that the mode of inheritance for dystonia (DYT1) is autosomal dominant? This to me implies that if one has both ...
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309 views

What are these strings used to describe animals?

For example, what's a $dt^{sz}$ hamster? (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1144494/). What's a Rgs9-Cre/+;gtROSA/+ mouse? ...
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36 views

Does the most common definition of “allele” include a change in phenotype?

I'm prepping an activity for my biology students on cystic fibrosis. There are about 2000 different mutations of the CFTR gene that cause CF. Since the final phenotype is pretty much the same, can I ...
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49 views

What is the close and related genome used for in Gene models?

all I am a little bit confused about using the related genome or reference genome. When we have a reference genome, we can do alignment. Also we can do the assembly. Can you give some more reason ...
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Do we get 1/4 of our genes from each grandparent?

I know that we get half of our genes from each parent, but does it necessarily mean we get 1/4 of our genes from each grandparent? Or is it possible that we might get say 30% from one grandparent, 20% ...
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120 views

Epistasis Involving Multiple Loci

The following problem is from Schaum's Outlines on Genetics, 5th edition, by Elrod and Stansfield. I'm having some trouble solving it. It is found under a section entitled "Interactions with Three ...
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1answer
72 views

Religion and Genetics

Are there studies that investigate the heritability of believing in supernatural things (or related concepts)? Or stated differently. Are there studies that ...
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1answer
40 views

What does “regulatory genomics” mean?

I have read about basics of molecular genetics ,although its not a thorough in-depth knowledge. I would like to know about "regulatory genomics". What is it actually?
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111 views

A photosynthesizing mouse?

N. Shubin's Your Inner Fish makes the point several times that there is a lot of functional similarity between some seemingly remote gene cousins. If that needed reinforcing we have the spider-goat, ...
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28 views

Property of E.coli harboring F element

From Genetics by Ursula Goodenough E.coli harboring an F element are endowed with a number of phenotypic traits : 1.They are sensitive to infection by ssRNA phages and certain ssDNA phages. ...
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44 views

Distribution of fitness in wild populations

If I get out in the wild observe wild populations and measure the distribution of fitness $f(w)$ in a given population. What will I find out? Will I observe a Gaussian distribution, a Poisson ...
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Evolutionarily speaking, why do humans have 46 chromosomes

In humans, each cell normally contains 23 pairs of chromosomes, for a total of 46. Monkeys, chimpanzees, and Apes have 24 pairs (twenty-four pairs), for a total of 48. What caused humans to have 46? ...
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365 views

On average how many genes / alleles do people share?

I am curious about how much more a child can be alike to one parent than the other. If a child were to inherit all the alleles that are shared between both parents from one parent, but inherit all ...
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2answers
4k views

Why do ladybugs have a different number of points on their backs

Everytime I see a ladybug I ask myself this question. Why does every ladybug have a different amount of points on its back? Is it because of its age? Or because of its genes? Is it inheritable?
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744 views

Genetics: pedigree following a rare trait autosomal recessive

I have two questions pertaining to this pedigree I believe it to be an autosomal recessive trait. The probability that individuals IV-1 and IV-2 would give rise to an affected individual would ...
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3answers
87 views

Definition of species - location of gene

I know that species have been classified on basis of reproduction , DNA similarity , niche, etc. Has there been a classification based on locus of genes ? What are the drawbacks/shortcomings of ...
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111 views

Gene perturbation, what is it used for, explain to computer scientists? [closed]

I am trying to build a gene regulation network, and I need some basic knowledge of it. So, in gene research, we perturb genes. Such as knock down them? Can people tell 2 or 3 experiment methods to ...
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1answer
45 views

Drosophila grey / yellow

I am studying biology by myself via distance-learning. I have been trying to solve the following problem for a while now and hoped you could help me. As this is "homework" I would appreciate hints ...
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61 views

In genome research, what is the problem in Mapping that may be caused by reads being too short?

In the following scenario: You were given short sequence reads of plant RNA obtained from a next-generation sequencing machine (fragments of 20–30 nucleotides in length). You attempt to map them back ...
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38 views

What information do microarray image convey?

OK I have read that a cell generates 4 kinds of digital (to be precise discrete) data namely DNA, RNA, Protein (sequences that can be encoded as string sequences of nucleotides/ amino acids) and micro ...
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53 views

What is the current scientific position on the issue of human race? [duplicate]

Race is perhaps one of the most controversial and sensitive issues in anthropology, biology, and other related fields. As a non-scientist, I've used google to probe the disparity between the positions ...
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51 views

Is there a possibility that medicine will affect the efficiency of natural selection?

I mean, saving sick people means that they possibly can propagate something that nature does not allow. I know that there is already something that operate at genetical level producing alteration, ...
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124 views

Do there exist publicly available Genome sequences of a family?

I would like to explore the genome sequence of a publicly available genome sequences of a family (like mother, father, son, daughter...). If such human genome sequences are not publicly available at ...
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1answer
110 views

What does chromosome CHR_Un, CHR_MT in the ftp site of NCBI mean?

I am not a biologist. But need some genetic data. So I searched internet and reached NCBI's website. I came to know from the FAQ page that I can the complete genome data of organisms from ...
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381 views

Correlation between genome size and mutation rate?

Martin Nowak in his book "Evolutionary Dynamics" talks about a given correlation between genome size and mutation rate. What correlation does exactly exist between these two concepts? Is it a ...
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78 views

Why only able to close one eyelid? Genetic reason?

Eye-dominance is a critical thing with bows: right-eye-dominant is recommended to do the aiming on the right eye here otherwise inaccuracy. This made me think whether all people are even able to do ...
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140 views

Help explain multi alleles in terms of actual genetic code

I understand that someones genetic makeup at an allele is usually denoted as (AA,Aa,aa). That means that instead of an A-T pair you get a C-G pair on none, 1 or 2 copies. Now, what exactly happens ...
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examples of chromosomal aberrations with lack of sexual chromosomes?

Are there any examples in animals where individuals survive having no copies of their sexual chromosomes?
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67 views

How well supported is the hypothesis that aging is mainly caused by the number of mutations in tissues?

I heard the hypothesis, that the (main) reason of aging is the increasing number of mutations in body tissues. The higher the number of mutations is, the older tissue is. Is this true? And how well ...
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1answer
41 views

Cosmid genomic library, or genomic cosmid library?

Which usage is better for referring to a "cosmid library of genomic DNA fragments"?
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1answer
93 views

Activation Of Embryonic Genome

Embryonic gene activation is a process by which the embryo begins to transcribe its newly formed genome.As the embryonic gene activation occurs during early stages the paternal genome may not have any ...
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1answer
78 views

Defining: Evolutionary (quantitative) Genetics and Population Genetics

How do we define the fields that are Evolutionary (quantitative) genetics and population genetics. What set these two fields apart? Can you try to provide definitions? To my intuitive understanding, ...
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1answer
248 views

Why are hybrids infertile?

Let's take a quote from Wikipedia about zebroids. Donkeys are closely related to zebras and both animals belong to the horse family. These zebra donkey hybrids are very rare. In South Africa, they ...
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296 views

How does chromosome cross-over occur?

I have heard that during meiosis, homologous chromosomes from each parent "cross-over", which enables the off-spring to inherit some alleles from the mother and some alleles from the father. The ...
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124 views

Are people genetically predisposed to being interested in specific fields/ideas? How does specialization occur?

I'm not sure if I formulated my question well, but I'm curious about a couple statements made by Steven Pinker and and James Heckman. In this interview: ...
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97 views

What is the current molecular explanation of Mendel's pea cross?

With reference to the simplest Punnet square for Mendel's pea plant experiments it occurred to me that I could not connect the little I know about genetics to the little I know about molecules. The ...
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1answer
29 views

Effect of the health of the male parent at the time of conceiving

Does it matter at all in determining the traits of a baby what the current health of the father is? For example, let's say I got diabetes at the age of 40 because of the poor lifestyle choices. Will ...
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48 views

How are oranges in the US or anywhere made seedless?

How are oranges in the US or anywhere made seedless? Please explain the broad principles and not the technicalities.
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How do exon tandem exon duplications occur in the genome?

By this I mean in cases where tandem exons are introduced by replication slippage how would a DNA polymerase by chance duplicate an entire exon cleanly (i.e. from exact start to exact end) when it ...
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81 views

Publicly available genotype data?

I am a statistician and I'd like to test my new method on biological data. For this I am looking for genotype data for a number of individuals. That is, I am looking for something like this: ...