Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Why do our epiphyseal plates close up in our late teens or early twenties?

What causes our epiphyseal plates close up in our late teens or early twenties? I realize that one's genetics plays the main role in this. I assume there is a gene that controls the epiphyseal plates ...
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46 views

Is epilepsy more heritable from maternal side?

I am thinking if paternal or maternal genetic line is the risk factor. Mitochondrial DNA is coming from maternal line. I do not know the pathogenesis of epilepsy so well that I could answer my ...
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91 views

How do I interpret this graph regarding introduced genes and virus-infected cells?

This graph appeared in a practice test for the MCAT. I am trying to interpret it, but it confuses me a bit. On the x-axis we have some introduced genes, and on the y-axis we have % of cells ...
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35 views

Does the most common definition of “allele” include a change in phenotype?

I'm prepping an activity for my biology students on cystic fibrosis. There are about 2000 different mutations of the CFTR gene that cause CF. Since the final phenotype is pretty much the same, can I ...
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38 views

What does “regulatory genomics” mean?

I have read about basics of molecular genetics ,although its not a thorough in-depth knowledge. I would like to know about "regulatory genomics". What is it actually?
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What does chromosome CHR_Un, CHR_MT in the ftp site of NCBI mean?

I am not a biologist. But need some genetic data. So I searched internet and reached NCBI's website. I came to know from the FAQ page that I can the complete genome data of organisms from ...
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109 views

Can someone who is color blind recover color vision by surgical means?

I am currently studying color blindness, and there is no medicine that can help it. Is it possible nonetheless for someone who is color blind to have their eyes restored to normal color vision by ...
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44 views

How are oranges in the US or anywhere made seedless?

How are oranges in the US or anywhere made seedless? Please explain the broad principles and not the technicalities.
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75 views

How does gene expression work in an adult organism? Is everything encoded everywhere?

The color of a person's eyes are genetically predetermined. If I knew how and in which gene(s) colors are encoded, I could change these genes in the ovary and sperm and thus change the eye color of ...
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Functioning of BRCA2

I know that BRCA2 interacts with RAD51 to repair DNA damage. But how exactly does it function ? What are the other proteins that interact with it ?
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Promoter in the lac operon

Here is the question: Suppose an experimenter becomes proficient with a technique that allows her to move DNA sequences within a prokaryotic genome. If she moves the promoter for the lac operon to ...
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Connection between genes and pathways

I am reading about a paper about inferencing pathway information in cancer cells. Authors refer to ERBB2 as a gene and a pathway. I don't have solid biology background. What exactly means when we ...
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37 views

What is mRNA expression level?

I cannot find clear explanation of what is mRNA expression level, and how to measure it. I would appreciate if someone explained it or gave a reference. Thanks!
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412 views

Why were dinosaurs not as smart as we are?

According to http://en.wikipedia.org/wiki/Dinosaur, Dinosaurs were the dominant terrestrial vertebrates for 135 million years. They had a lot of time to evolve. My question is: why were dinosaurs not ...
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131 views

How does smoking, an environmental factor, cause cancer, fundamentally a genetic disease?

If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking cause cancer?
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169 views

Hardy Weinberg Equilibrium after 5 Generations

1 There is a population not at HWE where red eye = $a^+$ (dominant) and white eyes = $a^-$. if $a^+/a^+ = 0.6$ $a^-/a^+ = 0.1$ $a^-/a^- = 0.3$ what are the frequencies of the $a^+$ and $a^-$ ...
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167 views

Accuracy of a particular genetics test

I am a newbie in biology and I am simply trying to discover the field of genomics. Consider the question - Are genetic tests accurate? I don't believe they are as the genes may not provide the ...
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480 views

What do rs id, allele coded 0 and allele coded 1 mean?

So, for a project I've been working on (different story), I've been looking at the HapMap Project, and their free online files. In their README file, they talk about how for each legend file for each ...
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96 views

What are Haplogroups?

What exactly does the term Haplogroup or Haplotype means? How is it claimed that people belonging to the same haplogroups have common ancestors?
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Is it possible to estimate how much variation in common phenotypes is predicted by genetics?

Phenotypes such as; skin color, eye color, nose shape, lip size, limb proportions, and skull shape. Im trying to find a source for this quote. "If you ask what percentage of your genes is reflected ...
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How did the Chromosome #2 Fusion propagate?

There is strong evidence that chromosome 2 in humans is a fusion of two chromosomes of a common ancestor of chimps and humans as explained at wikipedia here Was it necessary for the common ancestor ...
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37 views

regarding genetic disorders related to protein production

I am not completely familiar with biology, but i had a genetics course in college along with practicals. Forgive me if there is something wrong with my question. Is there a genetic disease which ...
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59 views

Could an annual plant be genetically modified to be a perennial?

My chives, asparagus, oregano, and rhubarb come back every year like clockwork. Suppose I want my bok choy to join the party - is there an "I'll be seeing you next year!" gene that can be modified to ...
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Valid comparison of gene expression between several genes in several cell lines

We have gene expression data (Affimetrix mRNA gene expression results) for several cell lines, over a set of genes. Our goal would be to be able to compare relative gene expression for genes over the ...
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In genome research, what is the problem in Mapping that may be caused by reads being too short?

In the following scenario: You were given short sequence reads of plant RNA obtained from a next-generation sequencing machine (fragments of 20–30 nucleotides in length). You attempt to map them back ...
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47 views

Why does the stability of YAC increase with size?

From Lehninger Principles of Biochemistry : The stability of YAC increases with size (up to a limit). Those with inserts of less than 100000 are gradually lost during mitosis. Why does this ...
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156 views

List of heritability estimates in humans?

Many people on this site ask questions that directly or indirectly have to do with heritability in human. Do you know a list of estimates of heritability of various traits in humans? Or could you try ...
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136 views

Troubleshooting for Agarose Gel Electrophoresis

SI ran my 2% agarose gel on constant voltage (100 V). For a few times it worked at CV but, after a week or so the machine would automatically switch to constant current by itself. And this only ...
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How can a YAC be screened against a cDNA library and a cosmid library of genomic DNA to find a gene?

I am reading fw2.2: A Quantitative Trait Locus Key to the Evolution of Tomato Fruit Size (doi: 10.1126/science.289.5476.85). The authors are trying to find the gene that makes tomatoes bigger. As far ...
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66 views

How usable is the Human Metabolic Model to predict biomass?

In order to use the Human Metabolic Model for Flux Balance Analysis of specific cancer cell lines, we would like to know what sort of flux values have been determined for the Human Metabolic Model. ...
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51 views

Determining whether X chromosome from sperm or egg

Is there any way of determining which X chromosome a female inherited from her father and which from her mom ?
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215 views

How can Southern blotting be used to establish gene copy number?

I am reading a paper on a certain marine microorganism that can eat alkanes and therefore might be useful for cleaning up oil spills, etc. This sentence struck me as odd (although I am sure that the ...
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169 views

How does electroporation mediated recombination work?

For yeast and other organisms, DNA can be readily taken up into the cell naturally or through membrane disruption. What does applying a voltage to cells do exactly that allows more recombination to ...
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What is genomic imprinting?

What is a genomic imprint? How does genomic imprinting take place? If I say that "this" allele is maternally imprinted does it mean that the allele of the gene is passed only by the mother? If a ...
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781 views

Difference between viral and human genetic material

I have heard that there is a difference between viral and human genetic material. What is that difference? If I take my cells and take DNA out of them and insert only a small part of it having a ...
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211 views

How do PLINK files and HapMap Phased files differ?

I know that PLINK and HapMap files show the same information, but can you give a thorough explanation of how exactly they differ.
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Transcription factor binding site located in intron

I have noticed that some TF binding sites are located in the introns of the genes. I am puzzled about whether the TF only binds to DNA in the initiation stage of transcription and will detach during ...
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146 views

What is the mechanism of regulation of PER /CRY genes?

I've read multiple descriptions of biological/circadian clocks and they all mention PER, CRY and CLOCK genes. While I kinda get how they are connected, what interests me is how these actually regulate ...
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135 views

What's the difference between a free chromosome fragment and an extrachromosomal array?

This is reference to a review on C. elegans mosaic analysis by Yochem and Herman, in which the authors make a distinction between free chromosome fragments and extrachromosomal arrays. For the ...
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Can a new Y-chromosome be created?

The major gene of the Y-chromosome is SRY. Would it be possible to get the X-chromosome and add SRY to create a "fuller" Y-chromosome? What advantage does the skinny Y-chromosome give an individual ...
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44 views

What is wrong with this analogy: Individuals are to alleles what governments are to individuals

I'm an amateur when it comes to genetics, I'm hoping to learn something from the corrections. I am taking epigenetics into account (kind of); all 3 entities are susceptible to external physical ...
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Limb polarity such as writing handedness, golf handedness and natural football foot

Define the term "limb polarity" to mean things such as writing handedness, golf handedness, throwing ball arm preference and natural boxing hand. I avoid using the term "handedness" because of its ...
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66 views

Definition of Sexual Selection?

How do you define Sexual Selection (SS)? (One might want to subdivide SS into intra- and inter- SS to answer) Is SS clearly different from Natural Selection (NS)? Is SS nested within NS or are NS ...
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37 views

Drosophila grey / yellow

I am studying biology by myself via distance-learning. I have been trying to solve the following problem for a while now and hoped you could help me. As this is "homework" I would appreciate hints ...
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39 views

Cosmid genomic library, or genomic cosmid library?

Which usage is better for referring to a "cosmid library of genomic DNA fragments"?
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34 views

Knockout Rat Phenotype Database?

Is there a database where I might list the phenotype of a certain rat knockout and/or search for other similar phenotypes? There is a International Mouse Phenotyping Consortium, which has the goal ...
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Maintaining purebred pedigrees and how to lessen chance of getting disease?

Many breeds of dogs are known for a high incidence of genetic disorders. German shepherd and Saint Bernard dogs are predisposed to developing a crippling condition called hip dysplasia. Q: What ...
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Epistasis when interacting loci are codons within a single gene

There is epistasis when the effect on the phenotype of one gene is influenced by one or more other genes (called modifiers). Is there a similar concept when the effect on the phenotype of one site ...
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119 views

Are these cats calico?

Calico cats are cats that have 3 fur colors and are always female or males two X chromosomes. I've seen many cats that will have 2 fur colors (one of them is usually white) and another, third, color ...
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Can a plant be programmed to produce any arbitrary object?

I'm wondering if a plant can be programmed (by modifying its genes) to grow into any shape that it's programming instructs. I understand that a plants genes are its instructions of how to convert the ...