Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Is there any reason for the variation in mitochondrial DNA size?

As my textbook An Introduction to Genetic Analysis points out, yeast mitochondrial DNA has approximately 78 kb of genetic data, while the human mitochondrial DNA contains 17 kb. Is there any evolution ...
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1answer
948 views

What is the distinction between F' plasmid and R plasmid?

Is there a difference between an F' plasmid that has taken up a chromosomal gene that conveys antibiotic resistance, and an R plasmid? Is a bacterium containing an R plasmid and yet lacking an F+ ...
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68 views

Are homozygous carriers of the CCR5-Δ32 allele fully immune to all known strains of HIV?

Or is there documented evidence of even one homozygous carrier contracting HIV and staying infected?
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1answer
231 views

Does the genetic expression of specific physical traits ever correlate to behaviour?

Over at skeptics, there were a couple questions asked as to the correlation of specific physical traits in relation to personality/behaviour. For instance, the simian line as well as red hair. Now, ...
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2answers
117 views

Is it possible to trace of the ancestry of a person by only using his/her genetic information?

Is it possible to trace the descent of a person only using his/her genome sequence?
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2k views

How is eye color in humans inherited?

In high school we studied the inheritance of eye color, as it was explained to us in the most simple way: blue eye color is a recessive, monogenic, autosomal trait. Now I know that it is a bit more ...
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1answer
254 views

How do members of cryptic species know who to mate with?

According to Wikipedia: In biology, a cryptic species complex is a group of species which satisfy the biological definition of species—that is, they are reproductively isolated from each ...
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198 views

Overlapping genetic information in eukaryotes

In my research, I look at a lot of gene predictions / annotations. Frequently, I see loci where multiple gene models overlap. I haven't taken a systematic approach to analyzing these cases, but I do ...
9
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1answer
88 views

Which patterns do I have to avoid when modifying the 3'-UTR?

I want to change a pre-miRNA sequence (in my case the pre-miRNA is encoding in a 3'UTR of a gene) and then put it in a lentivirus to see if it is still processed. After modification (permutation of ...
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4answers
4k views

Why 22 amino acids instead of 64?

This question got me thinking about amino acids and the ambiguity in the genetic code. With 4 nucleotides in RNA and 3 per codon, there are 64 codons. However, these 64 codons only code for 22 ...
13
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1answer
800 views

What is the smallest number of amino acids required for life?

Is there any hypothesis on the minimum number of amino acids required for life?
5
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1answer
99 views

What are the different ways an exon gets spliced?

Exons are produced by more than one mechanism, e.g. splicing out introns after transcription, if I remember correctly. Please list all mechanisms.
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3answers
2k views

What are the function(s) of Alu elements in the cell?

My 2008 biology book (1) states that some 10% of the human genome consists of relatively short (~300 nucleotides long) Alu elements which do not code for proteins but many of which are transcribed ...
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1answer
282 views

What is the functional and structural distinction between core (H2A, H2B, H3,H4) and linker(H1/H5) histones?

Many explanations of histone biochemistry isn't quite elucidating for the undergraduate student. How does histone structure (dimers, octomers) relate to their specific functions as core or linker ...
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6answers
791 views

Could Junk DNA be used as a Turing Machine by nature?

In what ways has DNA been studied to see if there a "programmable" aspect to it? Has nature produced anything resembling a Turing machine within the cell, perhaps using the "junk DNA" as its code? I ...
12
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2answers
269 views

Why was it so hard to decode the corn genome?

My teachers growing up told me it was impossible to decode the maize genome. But yet its been done. Why was decoding the genome so significant, and what made it so difficult?
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2answers
342 views

Smallest viable reproducing population

What is the smallest viable reproducing population, such as in a human population. By viable I mean a population which keeps genetic defects low (enough). A very strongly related question: what is ...
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1answer
619 views

What do the variants on the PolyT sequence mean?

My son has been diagnosed with Cystic Fibrosis. I am not looking for medical advice regarding his condition, but I am very interested in understanding the genetic causes of his condition. In ...
12
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1answer
482 views

How many people's DNA were involved in the compilation of the reference human genome?

I know that the reference human genome is complied from DNA portions from different people, most of whom were European. Do you know how many of them were involved? Do you know which ones were ...
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4answers
422 views

How are the boundaries of a gene determined?

What statistical processes and methods are used by geneticists/molecular biologists to know where one gene starts and one ends?
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2answers
302 views

Can an adult without genetic lactase persistence still develop a tolerance for dairy foods?

While investigating the rise of adult lactose tolerance, I came across the news that China has been encouraging its citizens to drink more milk, even though most of the Asian population lacks the SNP ...
10
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1answer
157 views

How can you identify if a person is homozygous for a certain allele?

I've been thinking about starting a small private research project. In this project I need to find out whether a person is homozygous for a certain allele. The reason for this is that I'm really ...
11
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2answers
387 views

What are limiting factors for intron length?

For predicting genes from a sequenced genome, you need to set a maximum intron length. How long can introns get in animals? Is there some limit?