Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Crossing over and exon shuffling?

Campbell Biology 10e, in discussing the functions of introns, writes: The presence of introns in a gene may facilitate the evolution of new and potentially beneficial proteins as a result of a ...
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Do only one or both pairs of homologous chromatids exchange genetic material during the process of crossing over?

To be specific: Assume chromosomes A and B are homologous. They've both replicated into A1, A2 and B1, B2 and have formed a tetrad at the equator (synapsis). Most textbooks show either A1 and B1 OR A2 ...
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57 views

Distinguishing Father from Brother

Given the (non-identical) DNA sequences of two men and the knowledge that the second man is either the father, brother, or son of the first man, is the DNA useful in determining which of these three ...
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1answer
20 views

What separates gene loci?

Introns are sections of noncoding DNA that separate exons within a gene locus. However, between different gene loci, I also would assume there to be noncoding regions of DNA. What are these regions ...
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1answer
43 views

Solving a Pedigree Between Heterozygous Half-Cousins

A man who is a known heterozygous carrier of oculocutaneous albinism marries his half-cousin (they share one common grandparent) as shown in the pedigree below. This trait is transmitted as a fully ...
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Why is a heritability coefficient not an index of “how genetic” something is?

On his blog, Eric Turkheimer writes: [T]aken as a number, a unit of analysis, heritability coefficients are funny things to aggregate on such a massive level. What exactly are we supposed to ...
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0answers
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How should one interpret heritability? Is it related to $R^2$?

From Wiki: Heritability estimates are often misinterpreted if it is not understood that they refer to the proportion of variation between individuals on a trait that is due to genetic factors. It ...
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3answers
9k views

Is it possible for a child to grow taller than their tallest parent?

I have heard that offspring can't grow taller than either of their parents but I've also heard that sometimes some gene activation can skip generations. Is it possible for a child to grow taller than ...
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1answer
59 views

what DNA you pass on to offsprings?

Our body contains many different types of cells and each of those cells have their own DNA (correct me if wrong) like skin cells their own DNA that makes them skin cells instead of muscle cells. So ...
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1answer
25 views

What does characterization mean in a genomics context?

"The resulting libraries of gene sequences allow CDC and other laboratories to compare the genes of currently circulating influenza viruses with the genes of older influenza viruses and viruses ...
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18 views

XNAs as a Genetic material [closed]

I heard there is a new genetic material called XNAs.I wanted to know more about this.Does anyone about XNAs as genetic material?
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1answer
21 views

Gemini usage of --sample-filter

I am using gemini to query databases made from vcf files, which contain data from multiple samples. However, I need to query data only from one sample, (for which I currently use grep to filter the ...
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28 views

Why does maximum likelihood rarely use morphological data? [on hold]

ML uses Dna rather than morphological data most of the time, unlike parsimony. I was just wonder why this is the case
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1answer
81 views

What is the difference between a bacterial artificial chromosome (BAC) and a plasmid?

Is it just that a BAC is generally larger and artificially constructed? Or are there any other differences?
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26 views

Is the relative amount off junk DNA a measure of an organisms complexity? [closed]

A rice plant contains as much active DNA (protein coding) as a human being. Can this be a sign that the more junk DNA the nucleus of a cell contains, the more complex the organism is that develops?
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0answers
17 views

Amplified Fragment Lenth Polymorphism (AFLP) primers

I am trying to blast AFLP primer sequences to the genome to find the locations of the AFLP markers. However, I can't seem to find full alignments for the primers on the genome. For example, in the ...
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2answers
40 views

Explain allelic complementation at molecular level

I know that Allelic complementation is a phenomenon where two recessive loss-of-function allele generate a functional gene product by compensating each others' defect. But I don't get how do they ...
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1answer
45 views

Why the length of UTR in the genomic sequence of gene X is too much longer than the same region in the corresponding Refseq mRNA sequences?

I'm browsing in the UCSC genome browser and found that the UTRs length of KIAA0040 gene in the genomic sequences is too much longer than the corresponding the Refseq mRNA sequence. In fact, the total ...
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1answer
34 views

Can heritability be deduced from a correlation coefficient?

I am trying to understand the concept of heritability and from what I can gather, the heritability of a factor (say birth weight) must be closely related to the correlation coefficient of that factor ...
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1answer
36 views

Was the frequency of mutations more during primitive earth due to radioactivity?

Primitive earth was more radioactive (or was it really?) according to radiometric analysis of C14 which suddenly appeared at 4250 million years in the Hadeon eon. Is it possible that ancient high ...
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1answer
36 views

Are scientist able to correct mutiple gene defect in our body by using CRISPR

Are scientist able to correct mutiple gene defect in whole body by using CRISPR recently? AS i know, it is in a beginning stage
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3answers
157 views

Swapping genes?

So, gene therapy is to take out a gene, correct its mutation, and put the corrected one back into the organism, right? Is it also possible to take out a gene from an organism and put in a totally ...
7
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1answer
63 views

Why does the proportion of transposable elements vary so much across species?

Intuitively, transposable elements (TEs) are harmful as they may cause genome instability. However, some people argue that TEs are also sources of variations, especially regulatory sequences[1]. If ...
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27 views

RAD sequencing: choosing the appropriate enzyme?

I’m studying Darwin’s finches genome and I say in some articles that the researchers used restriction enzymes to cut the DNA in their double digest RAD protocol. They are using EcoRI and MseI (GAATTC ...
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34 views

Incomplete dominance with gain-of-function allele

Can somebody site an example of incomplete dominance with gain-of-function mutation?
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2answers
30 views

Growth factors vs. mitogens

According to Campbell Biology, A growth factor is a protein released by certain cells that stimulates other cells to divide. and according to Wikipedia, A mitogen is a chemical substance ...
2
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1answer
86 views

Mutation-drift equilibrium and among loci variance in heterozygosity

At mutation-drift balance, the increased heterozygosity brought by new mutations is exactly equal to the loss of heterozygosity due to genetic drift. At equilibrium, the expected heterozygosity for a ...
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1answer
46 views

Ancestral Allele and Hapmap

I notice on dbSNP rs6352 has an ancestral allele of G - http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=rs6352 The hapmap in humans for this allele is very rare, the homozygous version practically not ...
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1answer
21 views

Genetic coding question, amino acid to base relationship

I'm studying for a test and I am confused by these problems/statements. How many amino acids will 18 bases code for? Answer: 6. I got this right. If a certain complete protein has 33 amino acids ...
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2answers
329 views

What are the major causes of mutations in DNA?

I know that point mutations can change the base sequence of a gene by altering a specific codon that codes for a particular amino acid. Are these mutations purely random events that occur when DNA is ...
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2answers
481 views

What is the difference between a fixed substitution and a single nucleotide polymorphism (SNP)?

I recently read a report that stated "We found 430 fixed substitutions […], with an additional 34 single nucleotide polymorphisms (SNPs) fixed within individual patients." What is the difference ...
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1answer
138 views

How significant is the genetic component of homosexual behaviour?

From some basic googling, I found that nobody has ever proven that people are born gay and that environment plays a great part in homosexuality. I wish to know if there is a genetic component to ...
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1answer
17 views

BWA-MEM single strand or doublestrand alignment

In whole genome secondary analysis does BWA-MEM use a double stranded fasta reference or are reads aligned to only one, single stranded fasta reference?
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1answer
23 views

“Heterozygotic expection” - when heterozygote differs from both homozygotes, but homozygotes are similar

For simple 2-alleles genetic model {a,A} and corresponding quantitative trait Q is typically true that Q(aa)>=Q(aA)>=Q(AA) or conversely Q(AA)>=Q(aA)>=Q(aA). For example, dominance means that ...
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1answer
62 views

What test to apply to detect genomic signatures of selection?

I would like to ask you for your sugestions for selecting a test to detect signatures of selection in the following mouse model: We have three groups: animals exhibiting trait A, trait B and ...
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19 views

Comparing genetics [closed]

Compare the possible effect on an individual of knowing that they have genes predisposing them to type-2 diabetes and the dominant allele that causes Huntington's disease. I am not sure about the way ...
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1answer
51 views

How difficult is it to make a shRNA/miRNA/siRNA to silence/knockdown NaV1.7 voltage gated sodium channels in humans?

There have been various research projects that experimented with shRNA/miRNA/siRNA to specifically silence/knockdown NaV1.7 voltage gated sodium channels in small animals like rats & guinea pigs. ...
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1answer
35 views

Why do Major and Minor grooves exist in dna strands? [closed]

I've been trying to find what causes the periodic appearance of major and minor grooves in DNA but have not yet been successful. Geometrical explanations would also be appreciated as I cannot ...
3
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1answer
29 views

What is working definition for female infertility?

I've studied infertility and found that its quite complex to define. However, I came to know about a useful working definition of infertility; which was " Failure to achieve pregnancy". Few days later ...
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316 views

Gene and alleles

This is a multiple choice question: Consider a gene, ABC, which codes for an enzyme involved in the metabolism of sugars. There are two known alleles of this gene, ABC1 and ABC2. Which statement ...
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198 views

Why asexual reproduction?

When I took a course on genetics and evolution, I learned that recombination and sexual reproduction is advantageous compared to asexual reproduction. Sexual reproduction allows more combinations of ...
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4answers
388 views

Can sexual reproduction create new genetic information?

Is there a small chance that in sexual reproduction a new allele forms in the off-spring that was not present in either of the parents, or are the alleles in the offspring always from at least one of ...
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1answer
47 views

Is HSV-vector-mediated miRNA expression in dorsal root ganglia stable?

My question is on the following article: "Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy" My question is, do ...
3
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1answer
314 views

Problem: What is this pattern of inheritance?

The following question was on a pretest of mine, and I'm trying to figure out the answer using what we've learned about Mendelian and non-Mendelian patterns of inheritance. I'm struggling quite a lot ...
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How to identify genes in Ralstonia that synthesize PHB and promote granule formation?

The compound polyhydroxybutyrate (PHB) is of considerable industrial interest as a biodegradable substitute for plastic. PHB is synthesized from glycerol by the bacterium Ralstonia eutropha. PHB ...
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1answer
39 views

The Semi-Conservative Model of DNA Replication: Question

My Campbell's Biology textbook contains the following diagram related to the semi-conservative model of DNA replication proposed by Watson and Crick. I have highlighted where my confusion arises in ...
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How was gene therapy able to CURE some diseases (I guess on cells that do NOT regenerate)?

Here's where I'm getting confused... I thought that gene therapy, when done on target cells that regenerate themselves constantly, can be effective for a limited time only (aka. The achieved effect ...
3
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2answers
39 views

Simple Mendelian sex-linked chromosome fruit fly question

From my molecular biology textbook: When red-eyed flies (dominant) were mated with white-eyed flies (recessive), most, but not all, of the F1 progeny were red eyed. Furthermore, when the red-eyed ...
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1answer
20 views

Constant or variable number of chiasmata during recombination?

During recombination, is the number of chiasmata consistent for each gamete and are the chiasmata regions consistent within a single organism?
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112 views

Is an egg classified based on the species inside it, or by the species that laid it?

Basically what I'm asking is if an animal of species x were to lay an egg, and the animal inside that egg happened to be the first member of a genetically new ...