Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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What do the letters 'p' and 'c' mean in mutation descriptions?

Example: NM_000525.3(KCNJ11):c. 67A>G ( p. Lys23Glu) AND Permanent neonatal diabetes mellitus Does "p" stand for "polymorphism"? What does the letter "c" stand for?
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2answers
477 views

Convert gene name to uniprot ID

i have a list of gene name in a file CHRNB2 EGR2 GCK KRT14 LMNA FGF3 TK2 ABCC8 How can I map them to uniprot ID ? P.S I tried Uniprot "ID mapping" (from-"GENEID"...
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1answer
232 views

Earliest and latest onset of Huntington's Disease(Chorea)?

Huntington's disease can hit at any age, although it tends to hit middleaged people most often. What is the youngest and oldest person that has exhibited Huntington's? Clarification: By oldest I mean ...
4
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1answer
72 views

Are all genetic instructions in DNA?

Wiki says DNA is a molecule that carries most of the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses. What ...
2
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1answer
74 views

Ancestral Allele and Hapmap

I notice on dbSNP rs6352 has an ancestral allele of G - http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=rs6352 The hapmap in humans for this allele is very rare, the homozygous version practically not ...
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1answer
37 views

ExAC Browser: What does a “dubious variant annotation” actually mean? [on hold]

I wonder how a "dubious" variant annotation is exactly defined in ExAC. I couldn't find any further information neither at the variant's page nor in the FAQs. Link to ExAC browser. Link to variant ...
0
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1answer
46 views

Determination of genes to be modified in epigenetics [closed]

It seems that during reproduction particular genes are targeted for modification (mutation, deletion, insertion, etc.) given environmental inputs of either or both of the parents. If a creature was ...
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2answers
115 views

Is it possible to have different genes in different parts of our body?

I want to understand genetic mutation specially in the context of multicellular organisms like humans. I studied biology only till high school and I can’t fully understand wikipedia pages on this ...
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0answers
14 views

Why can dogs not have a pink(ish) coat color?

In yellow dogs, there is a mutation in the MC1R gene which leads to a nonfunctional receptor. This leads to the production of pheomelanin which is pink/red (depending on concentration) instead of ...
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9 views

What's the difference between “mixing” and “combination” of chromosomes? [on hold]

What's the difference between "mixing of chromosomes" and "combination of chromosomes" ?
17
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4answers
2k views

Book recommendation on population/evolutionary genetics?

I have recently been involved in collaborations that require me to model the population genetics of eukaryotic populations. I fear I may either be "re-inventing the wheel" or making conceptual ...
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0answers
12 views

Is there any technique other than restriction enzymes to introduce staggered cuts into DNA?

I'm curious about introducing staggered cuts into DNA, but wonder if there is a way to do this in vivo in E. coli, as I heard introducing restriction enzymes on a plasmid would end up just shredding ...
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37 views

Is it possible to create the “perfect plant” at home? [closed]

I am starting a hydroponics farm/garden and I am interested in creating something like the perfect lettuce. I want attributes like crunch factor and shelf life. Is this a possibility that I could do ...
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0answers
17 views

How do you technically perform the Ames test?

Is it necessary to take into account the volume of gm-agar(bottom) in the concentration determination, or is that determined only by the concentration in the top agar? I found several articles that ...
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1answer
26 views

Can restriction sites be used as PCR primers?

I have a DNA fragment that contains the gene of interest sandwiched by restriction enzyme sites. Then, can PCR amplify the entire fragment, recognizing the restriction enzyme sites?
0
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1answer
46 views

Why People have skin color between fair and dark?

According to Mendel's laws traits do not show any blending. So according to his laws people only with fair or dark skin should exist. Do the alleles in this case blend? And why?
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1answer
35 views

Why was the study of “Concordance of Monozygotic and Dizygotic twins for traits” designed in this way? [on hold]

I am confused by the twin study 'Concordance of Monozygotic and Dizygotic twins for traits.' My questions arose from 3:17-4:17 of the video And this is the related data I have referred I have ...
1
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1answer
44 views

Why do mutations in Drosophila dsx (double sex) affect both males and females?

Reason: Loss-of-function mutation of dsx gene in female embryo leads to production of a nonfunctional protein that fails to repress male specific gene expression. So somatic characters of both the ...
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1answer
18 views

How to recognise the type of allele by pedigree analysis diagrams?

It was said that this interference pattern is due to dominant allele. I fail to see that. In general how to recognise the type of allele by pedigree analysis diagrams?
0
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1answer
54 views

Mendel Genetics: Homework question [on hold]

I'm looking at a question right now about Mendel genetics..... Q) When Mendel crossed a large number of tall pea plants with short pea plants, all F1 plants were tall. The F2 generation was created ...
0
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1answer
24 views

Are antibiotic-resistant bacteria necessarily less virulent than their original strain?

In the absence of antibiotic treatment, is there a reduction in the average severity of disease caused by resistant strains of pathogenic bacteria compared to wild-type ones? I would assume that ...
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0answers
20 views

Hybridization of an Indo-Aryan ethnic group and a Tibeto-Burmese ethnic group

The state in which I reside houses these two distinct ethnic groups. Physical Traits of the Indo-Aryan group Height:Medium Eyes:does not posses epicanthic fold Nasal bones:is not flat and broad ...
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1answer
40 views

Why does meiotic recombination disrupt the independent assortment of genes on the same chromosome?

There are many sources that say that genes that are "linked" by being on the same chromosome assort with each other -- that when an allele is passed on that the gamete containing said allele will also ...
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8 views

After how many generations our family resemblance change altogether? [closed]

I observe that one grandchild might be more different from his grandfather than his father, if so, obv he will be having more differences from his grand grand father.. After how many generations or ...
8
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2answers
364 views

Why is a heritability coefficient not an index of “how genetic” something is?

On his blog, Eric Turkheimer writes: [T]aken as a number, a unit of analysis, heritability coefficients are funny things to aggregate on such a massive level. What exactly are we supposed to ...
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0answers
16 views

Is genetic engineering in the eye possible? [closed]

Is it possible for iodopsin (photopsin) in cone cells to be genetically engineered to become rhodopsin so that retinal convergence could take place and therefore give some degree of colour in low ...
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2answers
52 views

What´s the origin of junk DNA?

Most eukaryotes posses a certain amount of junk DNA in their cell nuclei. What is (are) the origin(s) of this junk DNA, And is it realy junk (superfluous)?
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3answers
145 views

How is the size of a gene defined?

Is there an agreed definition as to how many nucleic acid bases constitute a gene? If not, why not? I'm not sure I understand how the exact sizes of genes are defined.
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28 views

How do I know if the tRNA gene is under purifying selection from looking at a sequence dataset?

I'm having trouble figuring out how to tell if a tRNA gene is under purifying selection, just by looking at its sequence dataset. Such as this one:
2
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1answer
4k views

Why is the function of lacA (encoding thiogalactoside transacetylase) not clearly understood?

It's almost half a century since the lac operon was discovered but isn't it weird that the precise role of transacetylase isn't clearly understood ? Here a wikipedia article with a link to a journal ...
3
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1answer
51 views

Perplexing by the way of estimating the shared or different genes between humans and chimps

We share 98.5% genes with chimps (it means we have 98.5% same DNA sequeces ),so there is about one percent difference .It means we can approximately differ from them by one base pair every hundred ...
8
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2answers
77 views

Is there a genomic code for nucleosome positioning?

What does a genomic code for nucleosome positioning in eukaryotes actually mean? By the code is it right to think that specific DNA sequences favour nucleosomes and others don't? I see that there for ...
3
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0answers
25 views

What is the effective population size of a simple two deme metapopulation?

I am confused as to how to compute the effective population size $N_e$ of a theoretical structured population. Let's consider here a simple case study. Imagine a 2-deme metapopulation. Each deme is ...
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43 views

Is there an evolutionary advantage associated with migraine? [duplicate]

I have read Wikipedia article on Genetics of migraine headaches and I don't buy it Because genetics influence susceptibility to migraine, it can be shaped by evolution. Fitness-impairing ...
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0answers
45 views

What types of species can produce genetically identical offspring? [closed]

Talking about identical twins, triplets, etc. I'm curious which types of species are able produce genetically identical offspring. Let's limit the scope to species that reproduce sexually and ...
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0answers
19 views

What does high level science actually say about the gay gene? [duplicate]

There is a lot of talk about genetics in the contemporary debate on the morality of homosexual behavior (and bisexual behavior, hereafter implied). As I understand the issue, the thought is not that ...
0
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1answer
25 views

What is the relationship between independent assortment and cross over?

During meiosis, the independent assortment will be made first and then cross over will be made. I am so confused, what is the difference between this two process? I looked at the diagram on internet....
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137 views

The human has 46 double chromosomes or simple chromosomes?

What I mean: does the human cell have 46 of these: or 46 of these: Thank you in advance.
3
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1answer
84 views

How likely is it that a person's progeny has an inheritable disorder based on this pedigree?

Case study: A person (let's just call him "John") had 3 aunts that died back in the 1950's in early childhood due to an unknown form of neuromuscular disorder. One died at birth, one at 2 years and ...
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1answer
46 views

Why must DNA be packed into chromosomes during mitotic phase?

Why does DNA have to be packed into chromosomes? Why can't DNA just divide itself evenly?
1
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1answer
49 views

Is it possible to remove one strand of double stranded DNA in vivo?

Assume we do have a double stranded DNA sequence in human cells, say ...ATCGATATCGATATTGCAGAGCATAGCTATAA... ...TAGCTATAGCTATAAGCTCTCGTATCGATATT... Now I want to ...
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0answers
19 views

Effects of pulverizing liquid nitrogen frozen tissue by by pestle and mortar

Does RNA, DNA or protein molecule break during pulverizing (liquid nitrogen) frozen tissue by pestle and mortar. As I want to make cDNA for qPCR, this is very important to me to know this.
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2answers
91 views

Can animals also get Down syndrome?

I heard that animals cannot get Down syndrome or trisomy. Is that true and why can't they get it? They also have chromosomes.
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1answer
50 views

Can we infect with “bad” genes other organisms? [closed]

We know that some organism's DNA stay with human for life (Herpes) and we also can, i think, design such "gene" that can interact with human's DNA-polymerase very intensive. If we attached this gene ...
4
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2answers
65 views

Do only one or both pairs of homologous chromatids exchange genetic material during the process of crossing over?

To be specific: Assume chromosomes A and B are homologous. They've both replicated into A1, A2 and B1, B2 and have formed a tetrad at the equator (synapsis). Most textbooks show either A1 and B1 OR A2 ...
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2answers
63 views

Are heterozygotes always fitter than homozygotes? Can inbreeding be beneficial?

Inbreeding is mostly not very good because when there is a 'disease' in one allele, the other could/would take over the function. But when you have two of the same genes/alleles, do they, or could ...
2
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1answer
52 views

Is it possible to have raw ngs data to practice

I'm looking for raw human ngs data to practice in bioinformatics. Better if it is from different machines (illumina, roche, pacsbio, etc). Panels, exomes and genomes. Anyone knows something?
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40 views

Has a restriction enzyme ever been tagged?

As part of an experiment that I am preparing, it would seem necessary for me to tag a restriction enzyme (HaeIII to be exact) with GFP. I began researching its domains to determine whether to tag the ...
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13 views

Difference in associated SNPs in GWAS

I noticed that when GWAS studies are being replicated, some SNPs near a gene known to cause a trait are enriched in frequency in those with the trait. However, among the different studies, the most ...
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0answers
43 views

Amplified Fragment Length Polymorphism (AFLP) primers

I am trying to blast AFLP primer sequences to the genome to find the locations of the AFLP markers. However, I can't seem to find full alignments for the primers on the genome. For example, in the ...