Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Horizontal gene transfer versus convergent evolution

There are several often noted examples of convergent evolution (eyes, bat/bird wing evolution etc.) How do we rule out horizontal gene transfer in these cases?
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Did the eugenics program in Nazi Germany have a measurable effect?

Did the killing or sterilisation of people considered as living a "life unworthy of life" in Nazi Germany have any measurable effect on the "average health" of Germany? Is there any statistical ...
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Schedules of mating for men

It’s simple deductive logic to follow that for a species to survive it must provide it’s offspring with the best possible conditions to ensure it’s survival – either that or to reproduce in such ...
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Book recommendation on population/evolutionary genetics?

I have recently been involved in collaborations that require me to model the population genetics of eukaryotic populations. I fear I may either be "re-inventing the wheel" or making conceptual ...
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Is the number of legs in myriapoda determined entirely by the genome?

Myriapoda (comprising, among others, millipedes and centipedes) can have hundreds of legs (Illacme plenipes having up to 750 legs). Interestingly, the number of legs (or leg pairs) appears to differ ...
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Are chromosomes from each parent split between gametes with equal probability (esp. in humans)?

I've recently read a little on Wikipedia about genetics, but I can't find a direct answer to this question. My rough understanding is this: Both males and females have pairs of chromosomes, one ...
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Turning publicly available genome data into proteins

I'm a computer scientist who is starting to dabble with biology. My eventual goal is to model different kinds of cells with a computer program. As of right now, I'm just trying to take some smaller ...
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59 views

Maintaining purebred pedigrees and how to lessen chance of getting disease?

Many breeds of dogs are known for a high incidence of genetic disorders. German shepherd and Saint Bernard dogs are predisposed to developing a crippling condition called hip dysplasia. Q: What ...
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coevolution by physical interaction between RNA sequences

There are several items that relate to the concerted evolution between pairs of sencuencias (especially structural) rRNA as a consequence of physical interaction in tertiary, or even quaternary ...
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detection of primary origin (natural selection or genetic drift) on alterations in sequences

I recently had a question about how to distinguish the origin of variations in the sequences of rRNA as to whether alterations are generated by genetic drift or natural selection. For me it has not ...
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61 views

Is it theoretically possible to treat filaggrin deficiency with a dietary supplement?

http://f1000.com/prime/reports/m/3/2/ "Filaggrin is a highly abundant protein expressed in the uppermost part of the epidermis that is critical to the formation and hydration of the stratum ...
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40 views

About the quality of microsatellites

I built a script to detect microsatellites in a FASTA file. However, there are thousands of possibilities. So, my question is: what are the markers of a "good" or "useful" microsatellite? - How ...
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psychological database with sequenced DNA records

I'm looking for an epigenetic database which includes for each example the psychological history of the persons DNA. Right now I can only find DNA and epigenetic databases. Sadly none of the databases ...
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How did the Chromosome #2 Fusion propagate?

There is strong evidence that chromosome 2 in humans is a fusion of two chromosomes of a common ancestor of chimps and humans as explained at wikipedia here Was it necessary for the common ancestor ...
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How many people are required to maintain genetic diversity?

Imagine humans were to colonize a distant planet and it was a single one-way trip. How many people would they need to bring? Obviously 2 is the minimum, but that would result in a lot of inbreeding. ...
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72 views

does order of genes in a chromosome matter?

does the order of genes within a chromosome matter? or is the main thing that the genes are there. so for example, our DNA is very similar to that of apes not only by the genes themselves but also by ...
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31 views

regarding genetic disorders related to protein production

I am not completely familiar with biology, but i had a genetics course in college along with practicals. Forgive me if there is something wrong with my question. Is there a genetic disease which ...
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48 views

Limb polarity such as writing handedness, golf handedness and natural football foot

Define the term "limb polarity" to mean things such as writing handedness, golf handedness, throwing ball arm preference and natural boxing hand. I avoid using the term "handedness" because of its ...
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2answers
88 views

Heterochromatin binding sites position information

I am working on a project and I'm trying to find data on the position of genes and heterochromatin binding sites such as HP1 in Drosophila melanogaster. Is this information available for the DGRP ...
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3answers
28 views

can recessive alleles produce codominance?

Maybe I'm confused by the term "codominance", but I wondering if codominance only occurs with two dominant alleles. Can two recessive alleles produce codominance in an individual? Likewise, can two ...
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what is the biggest known functional distance between an enhancer and its target gene (TSS) in cis?

since the title seems self explanatory; It would be nice if anybody could provide a reference. I'm looking for a paper that I belive stated around 1.5 Mb but anything above will be cordialy welcomed. ...
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48 views

Convert gene name to uniprot ID

i have a list of gene name in a file CHRNB2 EGR2 GCK KRT14 LMNA FGF3 TK2 ABCC8 How can I map them to uniprot ID ? P.S I tried Uniprot "ID mapping" ...
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How are new people created from the DNA of an aged person. i.e. Why are we young?

The question "why do we age" has been asked numerous times. But why are we young? The cells of the adult human being are an age (time>0), but how can old cells create new cells that are younger than ...
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Heterochromatin production limitations

Currently playing with some ideas for a project and needed some guidance. I am wondering, both in Drosophila melanogaster and in general, is the amount of heterochromatin a cell/nucleus can produce ...
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Theoretically, what technique would one use to modify a virus so that it only affected a subset of the population?

I'm writing a novel and i would like to know some of the equipment and techniques involved with modifying a virus. Is it feasible for a virus to be engineered to only affect certain people? It ...
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Theoretically, is domestication of (virtually) any animal possible?

Looking at ones that manage well alongside us human animals, such as dogs and cats, we see that this is possible for evolved, distant animals to have heritable, preferable traits around people. ...
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Could an annual plant be genetically modified to be a perennial?

My chives, asparagus, oregano, and rhubarb come back every year like clockwork. Suppose I want my bok choy to join the party - is there an "I'll be seeing you next year!" gene that can be modified to ...
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70 views

Recombination-based vs. Sequence-based genetic mapping

Now that sequencing is becoming increasingly cheap, what is the value of recombination-based genetic mapping against the sequence-based genetic mapping? I think that in the past recombination-based ...
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What is the purpose of back-crossing mice for multiple generations?

Occasionally I will come across articles that refer to back-crossing mice of one strain onto the background other another strain (e.g., C57Bl6). They do not explicitly state the purpose for doing so, ...
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42 views

Can a heterozygous allele show non-heterozygous expression in a family?

I'm doing a family study looking for novel cancer-associated variants in germ-line samples; the goal is to find candidate biomarkers which might be used for early detection. At an earlier step our ...
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83 views

How HIV Affects and Its Treatment using Combination Therapy

Can someone please help me with the following questions. I've written my specific questions right after the text question. Human immunodeficiency virus (HIV) is a retrovirus. Its genome is a single ...
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649 views

Chromosome 2 fusion?

I read this article by Jeffrey Tomkins and Jerry Bergman claiming to debunk chromosome 2 fusion. Is there anything wrong with these conclusions? " 1.The reputed fusion site is located in a ...
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What is doubling of genetic material invented in flowering plants?

David Attenborough in his Kingdom of Plants 3D said, that flowering plants made two inventions: (1) doubling of genetic material and (2) symbiosis with animals. What was meant by "doubling of genetic ...
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what is the difference between “cistron” and “gene”

I'm asking after reading the cognate wikipedia.en article on "cistron". I still am not sure about the difference of the two terms. To me it seems valid to picture a "cistron" as the genome wide set ...
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130 views

Ancestral Allele explanation

I'm having some trouble understanding the concept of ancestral allele. What exactly does it mean? What does it have to do with Identity by descent/state? What does it have to do(if anything) with ...
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Pedigree analysis : autosomal or mitochondrial

I have tried a to decide if this is a autosomal dominant, recessive or a mitochondrial disorder. Is it possible to know for sure, or do you have to use probability? (English is not my native ...
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460 views

Do trees age on a microscopic level?

Most animals age via at least two mechinisms: at a "macroscopic" level, basically wear and tear to the point where (on evolutionary time scales) it's more genetically advantageous to optimize for ...
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Valid comparison of gene expression between several genes in several cell lines

We have gene expression data (Affimetrix mRNA gene expression results) for several cell lines, over a set of genes. Our goal would be to be able to compare relative gene expression for genes over the ...
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Can someone who is color blind recover color vision by surgical means?

I am currently studying color blindness, and there is no medicine that can help it. Is it possible nonetheless for someone who is color blind to have their eyes restored to normal color vision by ...
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21 views

Primers on Dystonia

Where can I get a good biochemical overview of dystonia? I will be working in a research lab that focuses on dystonia and I would like to not be clueless.
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Mode of inheritance - DYT1 Dystonia

Homozygous DYT1 mutation carriers have not been reported in humans. Does this mean that the mode of inheritance for dystonia (DYT1) is autosomal dominant? This to me implies that if one has both ...
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298 views

What are these strings used to describe animals?

For example, what's a $dt^{sz}$ hamster? (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1144494/). What's a Rgs9-Cre/+;gtROSA/+ mouse? ...
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Does the most common definition of “allele” include a change in phenotype?

I'm prepping an activity for my biology students on cystic fibrosis. There are about 2000 different mutations of the CFTR gene that cause CF. Since the final phenotype is pretty much the same, can I ...
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How do I determine the parental type here?

Please consider the following question: You cross Drosophilia and receive the following offspring: 965 wild-type, 944 black- vestigial, 206 gray- vestigial, and 185 black- normal. Explain your ...
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47 views

What is the close and related genome used for in Gene models?

all I am a little bit confused about using the related genome or reference genome. When we have a reference genome, we can do alignment. Also we can do the assembly. Can you give some more reason ...
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Do we get 1/4 of our genes from each grandparent?

I know that we get half of our genes from each parent, but does it necessarily mean we get 1/4 of our genes from each grandparent? Or is it possible that we might get say 30% from one grandparent, 20% ...
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44 views

Epistasis Involving Multiple Loci

The following problem is from Schaum's Outlines on Genetics, 5th edition, by Elrod and Stansfield. I'm having some trouble solving it. It is found under a section entitled "Interactions with Three ...
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Religion and Genetics

Are there studies that investigate the heritability of believing in supernatural things (or related concepts)? Or stated differently. Are there studies that ...
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Penetrance Calculation of a Spontaneous Mutation

I'm trying to estimate the penetrance of a disease in a population given a rare spontaneous mutation that confers predisposition in an autosomal dominant manner. Given that the mutation is ...