Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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Effect of natural selection on the phenotypic variance. Empirical studies

Short background Theoretically speaking, natural selection causes a decrease in genetic variance and because the environmental variance should remain unchanged, natural selection causes a decrease of ...
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List of heritability estimates in humans?

Many people on this site ask questions that directly or indirectly have to do with heritability in human. Do you know a list of estimates of heritability of various traits in humans? Or could you try ...
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How are new chromosomes replicated into the next generation via sexual reproduction?

If an individual has a new chromosome, which is very unlikely to happen, he will not have any luck in finding a sexual partner with this same trait. How will the offspring inherit this trait. And ...
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How do exon tandem exon duplications occur in the genome?

By this I mean in cases where tandem exons are introduced by replication slippage how would a DNA polymerase by chance duplicate an entire exon cleanly (i.e. from exact start to exact end) when it ...
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Punnett square and hybrid cross [on hold]

A plant breeder crossed two plants, one with red flowers, and the other with white flowers. Red is dominant. Calculate the phenotype and genotype ratios of the F2 generation of this cross. Is this a ...
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Book recommendation on population/evolutionary genetics?

I have recently been involved in collaborations that require me to model the population genetics of eukaryotic populations. I fear I may either be "re-inventing the wheel" or making conceptual ...
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How does GC-content evolve?

Background GC-content refers to the frequency of base pairs that are either C or G in the genome, or in other words the number of GC base pairs divided by the addition of the number of GC base pairs ...
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How do I determine the parental type here?

Please consider the following question: You cross Drosophilia and receive the following offspring: 965 wild-type, 944 black- vestigial, 206 gray- vestigial, and 185 black- normal. Explain your ...
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Heterozygosity under genetic drift

The wright-Fisher model of genetic drift is: $$p_{ij} = \binom{2N}{j}\left(\frac{i}{2N}\right)^j \left(1- \frac{i}{2N}\right)^{2N-j} $$ ,where $\binom{2N}{j}$ is a binomial coefficient. From this ...
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Maintaining purebred pedigrees and how to lessen chance of getting disease?

Many breeds of dogs are known for a high incidence of genetic disorders. German shepherd and Saint Bernard dogs are predisposed to developing a crippling condition called hip dysplasia. Q: What ...
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Troubleshooting for Agarose Gel Electrophoresis

SI ran my 2% agarose gel on constant voltage (100 V). For a few times it worked at CV but, after a week or so the machine would automatically switch to constant current by itself. And this only ...
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Did the eugenics program in Nazi Germany have a measurable effect?

Did the killing or sterilisation of people considered as living a "life unworthy of life" in Nazi Germany have any measurable effect on the "average health" of Germany? Is there any statistical ...
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Is it possible for a brown eyed parent to have blue eyed child?

Here's the story: A young man has stunning blue eyes. On his mother's side are lots of instances of blue eyes, but on his father's side is no history of blue eyes. When he was born with these bright ...
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Hardy-Weinberg Equilibrium: To compute probability of finding two siblings (random mating)

I've been working a little with M. G. Bulmer's Principles of Statistics (Dover, 1979) and cannot see how to properly compute half of one question. This should be a basic probability computation, but I ...
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Which disorders are fully concordant?

I work in neuroscience, mostly Alzheimer's disease (AD), with some work in autism spectrum disorder (ASD). The work is in gene regulation and epigenomics. I'm familiar with monozygotic twin (MZ) ...
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Genetics problem-Height of a plant

An inbred strain of plants has a mean height of 24cm. A second strain of the same species also has a mean height of 24cm. When these plants are crossed the F1 are also 24cm in height.However, when the ...
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Why is the human body hair not uniformly colored?

Most of my body hair is black however my lip hair is light brown/blonde the rest of my beard region is black. Since hair color is genetic what causes this?
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Possible Genotypes — Linked Genes

Please consider the following question: Genes A and B are located on the same chromosome. If two individuals with the genotype shown below are crossed, which genotype could be formed? Let / ...
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How HIV Affects and Its Treatment using Combination Therapy

Can someone please help me with the following questions. I've written my specific questions right after the text question. Human immunodeficiency virus (HIV) is a retrovirus. Its genome is a single ...
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140 views

How was the Huntington's disease gene's location found?

I read in the book "Why we get sick." by Nesse and Williams that: Steady detective work and fabulous luck have enabled geneticists to pinpoint the Huntington's gene on the short arm of ...
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How does gene expression work in an adult organism? Is everything encoded everywhere?

The color of a person's eyes are genetically predetermined. If I knew how and in which gene(s) colors are encoded, I could change these genes in the ovary and sperm and thus change the eye color of ...
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Codominance and Partial dominance

The following genetic tree is given regard the fur color of some animal. The color determined by one gene that have two alleles and 3 genotypes: black, white and inlaid. I've been asked to ...
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Advantages of pain sensation?

The hazards of congenital insensitivity to pain (CIP) are well-known. This question is about the obverse: what selective advantage, if any, does the normal sensation of pain confer? I'm thinking of ...
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Population Genetics Question

Can someone please help with this question? Here is my working (just in case it is not clear: 1/300*1/30*1/2) but is this actually correct or do I need to multiply by 0.5 once again? I appreciate ...
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What is TILLING?

How does TILLING (Targeting Induced Local Lesions in Genomes) work? What is needed to perform a TILLING experiment, and what kind of information can we get out of it?
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What are the methods for infering genetic interactions?

Is there a classification of methods for inferring genetic interactions? I mean some work published, utilizes genetical genomics data. Is this possible with expression data alone? And how about ...
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How can a YAC be screened against a cDNA library and a cosmid library of genomic DNA to find a gene?

I am reading fw2.2: A Quantitative Trait Locus Key to the Evolution of Tomato Fruit Size (doi: 10.1126/science.289.5476.85). The authors are trying to find the gene that makes tomatoes bigger. As far ...
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How does a new species survive without suffering inbreeding?

Just what the title states. The thought came from reading When has an organism evolved enough to be called a new species? I'm probably wrong but I understand new species happen sporadically rather ...
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Cosmid genomic library, or genomic cosmid library?

Which usage is better for referring to a "cosmid library of genomic DNA fragments"?
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Hill-Roberston effects and effective population size

From this article, first page, middle of the second column: Even if harmful alleles do not become fixed, they can still reduce the efficacy of selection on neighbouring loci through a process ...
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Why does the slope of parent-offspring regression equals the heritability in the narrow sense?

Background ---- Notations and assumptions ---- let $W_{ij}$ be the fitness associated to the genotype $AiAj$. $x$ is the frequency of the allele $A1$ in the population. The frequency of the allele ...
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Fisher's Fundamental Theorem of Natural Selection

Ronald Fisher discovered what he, with humility, called the Fundamental Theorem of Natural Selection. This theorem says (in its modern terminology): The rate of increase in the mean fitness of any ...
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What does min mean?

I read that "trp operon is located at 27 min on E.coli chromosome." What does "min" mean ?
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Brainbow fluorescence labeling technique

I have this picture describing the Brainbow system here: The paper I am reading says it uses Cre-lox recombination to express a certain color. If the cell in question was expressing a yellow ...
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Property of E.coli harboring F element

From Genetics by Ursula Goodenough E.coli harboring an F element are endowed with a number of phenotypic traits : 1.They are sensitive to infection by ssRNA phages and certain ssDNA phages. ...
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How can a recessive allele propagate until they manifest?

Suppose a specific gene has two possible alleles. In a given population all members have only the dominant one. By a mutation on member receives the first recessive allele of that population. Is it ...
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Do white Australians have a distinct look?

Background I've heard from many people working in tourism or similar industries that, white Australians can be recognized as Australian solely by their facial features. Being Australian myself I've ...
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Knockout Rat Phenotype Database?

Is there a database where I might list the phenotype of a certain rat knockout and/or search for other similar phenotypes? There is a International Mouse Phenotyping Consortium, which has the goal ...
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Understanding DNA supercoiling

While trying to understand DNA supercoiling, I came across these lines in the book Genetics by Ursula Goodenough : All natural DNA is superhelical. The axis of the duplex itself follows a ...
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Quantitative Traits Genetics

Can someone please help with this question? I'm not so sure whether part A should be 11 inches or something else. Also, is part B correct
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How do I calculate the change in allele frequency in a haploid population under selection?

From this book For simplicity, let us consider a haploid organism and assume that the frequencies of alleles $A_1$ and $A_2$ are given by $x$ and $y=1-x$, respectively. We also assume that the ...
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Why doesn't recombination occur in male Drosophila?

"Males do not show meiotic recombination, facilitating genetic studies." For a while I have known that this phenomenon occurs, this quote comes from the Wikipedia page on Drosophila melanogaster, ...
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Affect of the health of the male parent at the time of conceiving

Does it matter at all in determining the traits of a baby what the current health of the father is? For example, let's say I got diabetes at the age of 40 because of the poor lifestyle choices. Will ...
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DNA adaptation in human life

Does our DNA adapt by human lifetime? Or do we have the same genetic information from birth to death? I mean: What is usually called "evolution" means "natural selection" like this: ...
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What is the role of hippo signalling in oral squamous cells

What role do hippo signalling have on squamous cells in oral health & diseases
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Is it reasonable to assume that RNA polymerase would bind preferentially to the promoter of the long allele of the SERT gene?

I'm trying to come up with an idea for a school project (a hypothetical research study). I'm looking at depression and the serotonin transporter gene, which is highly expressed in the human ...
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Publicly available genotype data?

I am a statistician and I'd like to test my new method on biological data. For this I am looking for genotype data for a number of individuals. That is, I am looking for something like this: ...
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Could mating/recombination be responsible for evolution of entirely novel features?

The diploid chromosomal architecture is rather interesting. For example, because of diploidy we Humans have to mate. Of course in that sense, because diploid organisms often have mate, this has led to ...
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How many transcription factors are there?

In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to ...