Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics.

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How can the phenotypic effects of a tumor suppressor mutation be silenced?

I've been reading a little about the "two-hit" hypothesis for tumor suppressor genes here, which mentions that some genes exhibiting haploinsufficiency are exceptions to the hypothesis. I've read ...
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Are there mechanisms that limit the amounts of time conjugation and F-plasmid transfer can happen? If yes, what are they?

Not all bacteria have acquired F-plasmids through conjugation. Some of the mechanisms for this are unsuccesful conjugation events (mechanical disruption), no transfer due to integration in bacterial ...
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How was the cama's life expectancy computed?

A cama is a hybrid between a male dromedary camel and a female llama. The first cama was born on January 14, 1998, yet on the Wikipedia page it is said that a cama's life span is 30–40 years. How was ...
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200 views

Genetic expression in interspecific hybrids

Referring to interspecific hybrids, I have the following two questions:- Quoting from wikipedia:- The offspring of an interspecific cross are very often sterile; thus, hybrid sterility ...
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effect of background selection on promoter regions compared to distant enhancers?

Has anyone looked at the effect of background selection on the levels of conservation of promoter regions compared to distant enhancers? Do promoter regions have a higher conservation due to ...
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Double stranded is more 'durable' than single stranded stuff?

I'm struggling with a question I've been asked. "Why is double stranded genetic material more 'durable' than single stranded one?" I know that double stranded genetic material is more stable due to ...
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76 views

What is the frequency of double-hets between parent and child?

Say both parent and child are genotyped for all SNPs. In this setup we are only looking at variant positions between one parent and child - so neither parent nor child are homozygous reference (no ...
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34 views

Y Chromosome in Ovary Cancer Data

I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome ...
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15 views

What is the most reliable tumour suppressing gene for NSCLC?

I was looking at some tumour suppressing genes that can be helpful in diagnosing lung cancer (particularly NSCLC - Non-small-cell lung carcinoma) at an early stage. I came across a few such as p53, ...
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78 views

At what rate do chromosomal rearrangements occur?

How often does chromosomal rearrangements occur? i.e. what is the rate of chromosomal rearrangements? I am interested about these kind of chromosomal rearrangements that are passed on to the ...
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138 views

Gibson assembly using NeBuilder

I am supposed to construct a plasmid that contains features from two other plasmids. My strategy is to generate three fragments form the two other plasmids. I was encouraged to try Gibson assembly, ...
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74 views

Could miniaturization be used to protect endangered large species?

In some animals (like dogs) size seems like it's controlled mostly by just a few genes (IGF1, and the genes that repress it). I'm curious: (1) Does other miniaturization takes a similar route (for ...
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90 views

Eye color genetics

I am trying to find a model to link the phenotype eye color to its genotypes. I know that there exists a simple model from Davenport, which explains {brown,blue} eyes. Further, there is an extended ...
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56 views

What are polytene bands, and why are they there?

Drosophila polytene chromosomes have been particularly useful in genetic research, as it made cytogenetic gene mapping possible with very little effort. This was primarily accomplished due to polytene ...
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Problem involving selfing (inbreeding it with itself) a plant to generate purebred lines

I am working on a past exam problem where the first bit is as follows A plant is repeatably selfed to generate inbred lines. Let $\mathbb{P}(He|He)$ denote the probability that a heterozygous ...
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29 views

Do The Traces Genetic Diseases Remain in families?

I know that there are certain diseases that are predominant on genes. But, is there any sort of surety that if parents are suffering from a disorder then their offspring has to suffer from the same. ...
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Resource for finding Repressive/Inhibitory factors for a given gene?

I have a list of genes for each of which I'd like to find: A list of transcription factors that up-regulate the gene A list of inhibitory factors that down-regulate it. I used this tool on ...
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51 views

Modified Mendelian Ratios Problem

I'm studying modified Mendelian ratios. I've got a theoretical problem that I'm stumped on: A species of bird may have normal wings, or a mutation that causes frazzled wings. I do 15 identical ...
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40 views

Where can I upload non-human Genotype data?

I have genotype data from few chicken population and I want to (need to) upload them somewhere online with free access. I have searched the web but I haven't found any place for non-human genotype ...
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46 views

Mutation-drift equilibrium and among loci variance in heterozygosity

At mutation-drift balance, the increased heterozygosity brought by new mutations is exactly equal to the loss of heterozygosity due to genetic drift. At equilibrium, the expected heterozygosity for a ...
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25 views

Can two Hfr strains of E. coli conjugate?

Genetics textbooks (and some internet searching) yield abundant examples of Hfr strains conjugating with F- cells, but these sources are surprisingly silent regarding the results of an Hfr ...
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Genetically improved *Leucaena leucocephala* seeds

I am looking for fast growing Leucaena leucocephala seeds. Now, I am cultivating Leucaena leucocephala which can grow 6 meters in a year. But I am looking for a genetically improved seed which can ...
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54 views

Can a heterozygous allele show non-heterozygous expression in a family?

I'm doing a family study looking for novel cancer-associated variants in germ-line samples; the goal is to find candidate biomarkers which might be used for early detection. At an earlier step our ...
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examples of chromosomal aberrations with lack of sexual chromosomes?

Are there any examples in animals where individuals survive having no copies of their sexual chromosomes?
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35 views

What is TILLING?

How does TILLING (Targeting Induced Local Lesions in Genomes) work? What is needed to perform a TILLING experiment, and what kind of information can we get out of it?
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Is it reasonable to assume that RNA polymerase would bind preferentially to the promoter of the long allele of the SERT gene?

I'm trying to come up with an idea for a school project (a hypothetical research study). I'm looking at depression and the serotonin transporter gene, which is highly expressed in the human ...
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93 views

Best way to automatically link Gene Entrez ID with Gene Symbol in TCGA

I am trying to figure out how to link Gene Entrez ID with Gene Symbol, for TCGA dataset. So far, I have found this ftp directory with Gene info updated daily. But, for Entrez ID 728661, I have found ...
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Swapping genes?

So, gene therapy is to take out a gene, correct its mutation, and put the corrected one back into the organism, right? Is it also possible to take out a gene from an organism and put in a totally ...
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Why do restriction-modification systems work?

Some RM systems (restriction-modification systems) are plasmid-borne and are transferred through bacterial conjugation. As you all know, there are two genes in an RM system, the gene that codes for ...
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51 views

How does a baby retain a blood group different from it's mother, in her womb?

It's a well-established fact that blood group is decided by genotype. But, when a new child starts it's journey in the womb, then the mother's blood (along with it's agglutinins and agglutinogens) ...
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Is this description of etiology of celiac disease correct?

There is a detailed and, to my inexpert eyes, plausible description of the etiology of celiac disease and other autoimmune disorders posted here: http://no-gluten.org/CeliacDisease.htm Is it is at ...
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67 views

Blood type frequency given probability

I have calculated the probability that any child will have a particular blood type from both the genotype level and the phenotype level assuming the human ABO Rh system is followed. Here are the ...
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47 views

Word denoting genetic state

Is there a single word, or brief phrase, that denotes the state of the total genetic machinery (genome + transcriptome + proteome + ...) of a cell or organ or organism at a particular point in time?
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Can sealed epiphyseal growth plates theoretically be restored via epigenetic or genetic methods?

I know that epiphyseal growth plates seal up once people become young adults and that it is currently impossible to restore them to actively produce new bone growth but, is it theoretically possible ...
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How TCGA CNV values are calculated?

When I download CNV SNP array data for ovarian cancer from TCGA data portal, I see some very small numbers like -5, -6 in the "Segment_Mean" column of the segmentation data files. I am very new to ...
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87 views

An unknown band appearing in my gel electrophoresis

I am having trouble understanding what is the source of band "2" in the following gel-electrophoresis: In this experiment, we took an E.coli transformant colony and ran its nucleic acids in the ...
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79 views

Why only able to close one eyelid? Genetic reason?

Eye-dominance is a critical thing with bows: right-eye-dominant is recommended to do the aiming on the right eye here otherwise inaccuracy. This made me think whether all people are even able to do ...
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Which disorders are fully concordant?

I work in neuroscience, mostly Alzheimer's disease (AD), with some work in autism spectrum disorder (ASD). The work is in gene regulation and epigenomics. I'm familiar with monozygotic twin (MZ) ...
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Referencing the homologous chromosomes

There exist a co-ordinate system from chromosomes like "12p11.3". In this system, first integer range from 1 to 23 i.e it takes homologous chromosomes as a pair. If we want to distinguish among ...
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What is neutral genetic differentiation?

What is neutral genetic differentiation? Presumably it's a measure of the distance between organisms in terms of their genetics, but what does 'neutral' refer to?
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Genetic Relationship Matrix

The classical definition of the Genetic Matrix G = ZZ'/2p(1-p) where Z = M - P where P = 2(p-0.5) I don't have a background in biology but understand Maths and ...
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Where to find gene manipulation video (or photos)

I hope Im not asking a dumb question! Where can i find video of gene manipulation in action under microscope? Like extracting a gene from a cell, fixing gene mutations, putting the gene in a vector, ...
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Solid mouse (C57BL/6) WT primers

I am trying to get a good pair (or better yet, library of pairs) of primers that give me one band in WT mice (C57BL/6). Do you know where I could find such a thing? Alternatively, I thought of just ...
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36 views

Barr body Giemsa staining

Why not all the female cheek cells show Barr Bodies when stained with Giemsa stain?? only 30 to 40 % female cells showed Barr Bodies . Why?
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35 views

Layman definition of genetic polymorphism?

I am reading an article about Genetic Polymorphism and there are lines in the article about genetic polymophism that I don't quite understand like. In this area,there are six different chemotypes ...
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45 views

What are the white spots?

What are these white spots? It's like Braille writing or something. How is the appearance encoded in the plant? (which I think is a Pine, though I am not sure).
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In insects, does the Alanine repeat occur on the homeodomain sequence of the abdomen or does it occur on a different sequence?

By "Alanine repeat", I am referring to the suppression of the formation of extra insect legs due to Ubx gene suppression through Distal-less repression.
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What is the gene regulation behind human adaptation to higher altitudes and therefore higher hemoglobin levels?

Some people in the Amazonian forest and in Himalayan mountains have reported living perfectly with extremely high levels of hemoglobin. I was wondering what type of gene regulation goes on in order ...
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Known ways to modify the genetic structure of the 13 loci used in CODIS

After reading the answer to Does our DNA change during our lives?, I was wondering if and how it would be possible to change the structure of the 13 loci that are used in the CODIS database, in such a ...
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What log transformation and normalization functions are most commonly used for microarray and how to select them?

Need help on rational approach to choosing log transformation, standartization and normalization functions in microarray experiments. I am using Expander software and it provides Log2 transform and ...