Genetics is the branch of biology that deals with the transmission and variation of inherited characteristics, particularly chromosomes and DNA.
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How did the activities of protocells become inheritable?
I have learned that first a protocell came to exist and its characteristics came to be passed on by genetic material. So how come genes for all the activities come to incorporate into genetic ...
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2answers
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Which texts are good for beginners to understand evolution on the genetic scope?
Are there good texts to study the evolution, how it works, and how mutations and changes lead to evolution of the organism ?
And how does the information increase through the long time using ...
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Low complexity region and relaxed selection
I'm reading a text (Wagner, 2007) on identifying positive selection. In paper, the author says that low complexity regions are known to be associated with relaxed selection. I'm trying to understand ...
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1answer
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Mapping a mutation to known SNP, 3' UTR, miR
I've parsed out a very large TCGA cancer ssm (single mutation file) file to give me the essential information.
The ssm is in the following format:
...
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1answer
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TCGA data, and bioinformatics design questions for SNP/ mirna analysis
It's my first time posting to this forum but was looking for some help on the data aspects of this project.
My tools of choice would be in python/R .
Goal: I'm looking to create a disease specific ...
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paralogue genes in genome-wide association studies?
Has anybody tested if there is an over-representation of significant paralogous copies of genes -- either tandemly-arranged or in different chromosomes -- in the list of significantly associated genes ...
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What is the frequency of double-hets between parent and child?
Say both parent and child are genotyped for all SNPs. In this setup we are only looking at variant positions between one parent and child - so neither parent nor child are homozygous reference (no ...
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0answers
40 views
What are polytene bands, and why are they there?
Drosophila polytene chromosomes have been particularly useful in genetic research, as it made cytogenetic gene mapping possible with very little effort. This was primarily accomplished due to polytene ...
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Terminology question: the scope of an allele in an organism
Let us consider a gene FOO with novel type foo.
If I were discussing an organism that has inherited foo in every cell during classical zygote formation, then I would ordinarily just say that the ...
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How does a plant decide when to grow a branch?
As a plant grows, at some point the first branch forms. As it continues, branches grow new branches, and so on, in a seemingly random way. Is it random, or is it driven by the environment (heat or ...
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effect of background selection on promoter regions compared to distant enhancers?
Has anyone looked at the effect of background selection on the levels of conservation of promoter regions compared to distant enhancers? Do promoter regions have a higher conservation due to ...
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0answers
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Is there a gene that starts meiosis 2?
Yesterday I thought about a question and asked it to my friend. The question was
which gene is completely the same for a male cell that made meiosis 1 recently.
My answer was the gene that starts ...
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0answers
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Eye color genetics
I am trying to find a model to link the phenotype eye color to its genotypes.
I know that there exists a simple model from Davenport, which explains {brown,blue} eyes. Further, there is an extended ...
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0answers
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What is neutral genetic differentiation?
What is neutral genetic differentiation? Presumably it's a measure of the distance between organisms in terms of their genetics, but what does 'neutral' refer to?
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Randomized experimental design in genetic experimentation.
I am struggling to find out if randomization is used in traditional genetic breeding experimentation with model organisms, especially in lab contexts? And why this should be so? This is part of a ...
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0answers
41 views
Can mammals from different species reproduce?
I'm curious on how genetically different can two animals be in order to reproduce. Could they belong to different species?
One example is the mule which is the offspring of a donkey and a horse, in ...
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0answers
29 views
Recombination-based vs. Sequence-based genetic mapping
Now that sequencing is becoming increasingly cheap, what is the value of recombination-based genetic mapping against the sequence-based genetic mapping?
I think that in the past recombination-based ...
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0answers
84 views
Extreme examples of protein translation/use coupling/decoupling?
What are known extreme examples of protein translation/effect coupling/decoupling? For example, examples of proteins that are immediately used at the time the have been translated and vice versa, ...
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35 views
Hardy-Weinberg applied to three alleles and stimation of allele frequencies
I have this equation:
Corresponds to HW in equilibria with three alleles:
$(p+q+r)^2=1$
Expanding the square results:
$p^2+2pq+r^2+2pr+q^2+2qr = 1$
I need to separate homozygous and ...
