Questions pertaining to genome-wide association studies.
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1answer
40 views
Interpreting SNP-in-gene associations from GWAS studies
For most SNPs identified in GWAS studies, is the underlying assumption that if it is indeed associated with a phenotype (and lets assume its associated because it affects protein function), that you ...
8
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2answers
435 views
What is the difference between naive and adjusted p-values in a GWAS study?
What is the difference between a naive p-value and an adjusted p-value in the results of a GWAS study? See from this paper:
After Bonferroni adjustment, a single gene, DCTN4 (encoding dynactin 4) ...
7
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0answers
57 views
paralogue genes in genome-wide association studies?
Has anybody tested if there is an over-representation of significant paralogous copies of genes -- either tandemly-arranged or in different chromosomes -- in the list of significantly associated genes ...
2
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1answer
49 views
variation in expression accounted for a SNP — what's a usual percent?
I am reading a GWAS paper that found a SNP associated to predisposition to colon cancer and was assessed for gene expression of the nearby gene. They found that the genotype accounted for 55% of the ...
5
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1answer
135 views
What is the relative power of GWAS studies in different species?
I would like to know of any publication studying the relative power of GWAS studies in different species. For example, I've seen reports that say genotyping and GWAS in dog breeds is much more ...
