Hallucinogens are compounds that induce hallucinations and often other psychotic phenomena. They include dissociatives (NMDA antagonists and kappa opioid agonists) and psychedelics (LSD and psilocybin).

learn more… | top users | synonyms

4
votes
2answers
63 views

What is the biological principle of this “holotropic breathwork” technique?

Holotropic breathwork is a non-drug technique developed by Stanislav Grof used in psychotherapy. The therapy as a whole is usually called holotropic breathwork (at least by Grof himself) and will most ...
3
votes
1answer
109 views

Do serotonergic (5-HT2A-mediated) psychedelics elicit stimulant effects?

I know that 5-HT2A partial agonism is the key mechanism of action of serotonergic psychedelics but I also know that some research (e.g. the selective (no activity on any other known receptor sites) ...
1
vote
1answer
177 views

Does the NMDA antagonist, Memantine that's used to prevent Excitotoxicity cause brain damage?

Does the NMDA antagonist, Memantine that's used to prevent excitotoxicity in Alzheimer's disease (AD) and Dementia with Lewy Bodies (DLB) cause brain damage? I know that in rodents NMDA antagonists ...
1
vote
1answer
57 views

Dimethyltryptamine and Sigma 1-type opioid receptor interaction

Where exactly do dimethyltryptamine and sigma 1-type opioid receptor interact? I read in this When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor but it ...
1
vote
0answers
24 views

Which Receptors are involved in Psychedelia/Psychosis? [closed]

Which receptors are involved in Psychedelia/Psychosis? I know that the 5-HT2A, 5-HT3, D2, κ-opioid and NMDA receptors are likely involved in psychosis.