Histamine is a neurotransmitter that plays a key role in allergenic responses, sleep, alertness, cognition and gastric acid synthesis and secretion. It binds primarily to the four types of histamine receptors, H1 (responsible for alertness, cognition, allergenic responses), H2 (responsible for ...

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What's the Mechanism of Paradoxical Excitatory Effects with Sedating Antihistamines?

I've been reading the British National Formulary 65 (BNF-65) and it mentioned that in some, especially at higher dosages, sedating (first-generation) antihistamines, can produce paradoxical excitatory ...
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How do Opioids Stimulate a Histamine Release?

Histamine is a neurotransmitter that also has peripheral functions such as the regulation of gastric acid secretions, allergic responses, etc. I know that opioids stimulate a release of histamine but ...