The Human Immunodeficiency Virus (HIV) is a single-stranded RNA virus which reproduces in human CD4-positive cells, which are primarily T-helper lymphocytes and macrophages. HIV is the causative pathogen of Acquired Immunodeficiency Syndrome (AIDS).

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Effect of HIV on T-cells

When HIV infects macrophages, it doesn't kill or destroy them immediately, but once it infects T-cells, they're destroyed. Why is that? As in why does it destroy T-cells and not macrophages or other ...
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Can HIV be transmitted via mosquitos?

It is known that HIV is usually transmitted by direct blood or body fluid contact between an infected individual and a healthy person (like blood transfusion or needle sharing): Suppose a mosquito ...
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How does a person get AIDS?

I am inquisitive to know about how a person contracts AIDS. Among the common masses it's still the belief that having sex with multiple partners causes the disease but that is not the case when read ...
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Why is HIV so large compared to other viruses?

The HIV-1 virus is about 120-150 nm in size and has a genome only about 10,000 base pairs long. Other viruses are far more efficient, for example lambda phage has something like a tenth the volume ...
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Why is HIV associated with weight loss/being underweight? [closed]

It seems that people with HIV are often underweight, is there something (or multiple things) which cause HIV sufferers to lose weight? What is happening within the body as a direct effect of HIV that ...
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In the life-cycle of the HIV virus, how does the created DNA enter the nuclear membrane?

I am in a high school biology class, so I cannot truly attest to how accurate the information I am given is, but as far as I know only RNA and very small molecules can enter the nuclear membrane ...
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Why is AIDS not a congenital disease?

AIDS can easily pass from mother to the newborn, then why do we not consider it to be a congenital disease (or syndrome)
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How is HIV evolutionarily viable despite its extreme virulence?

How does HIV survive natural selection? And how has it managed to kill far more than any non-airborne virus in recorded history?
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What are the effects of removing CD4 receptors?

If the gene for the CD4 receptor was removed, would the person's immune system work normally? Could a new artificial receptor be substituted in place of CD4? Could HIV infection be prevented in this ...
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Engineered CD8 T-cell therapy for HIV infection

CD8 T-cells are effective in controlling HIV during the early phase of the infection. However by the time, the virus mutates and develops an evasion mechanism against CD8 T-cells. Since cancer cells ...
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HIV and open reading frames

In Wilk et al. 2001 I saw that HIV has 3 open reading frames. In the Watts et al. 2009, I noticed they mentioned HIV has 9 open reading frames. I don't understand this very well. e.g. ...
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Why do doctors still advise HIV+ couples to wear a condom during sex?

HIV infected people already have HIV, but why do doctors still advise condom use for HIV+ couples?
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Can people with AIDS get tattoos?

When I do a Google search, most of the results are about whether or not people can get HIV / AIDS from getting a tattoo through dirt needles. I am, however, curious whether or not it is possible to ...
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Why does HIV belong to a group of retroviruses called lentiviruses?

HIV is an enveloped retrovirus. Each virus particle contains two copies of an RNA genome. The virus also has a number of enzymes: reverse transcriptase, integrase and viral protease. But, once I also ...
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Transmission of HIV from Mother-to-Child Through Breastfeeding

If a mother is HIV+ and was on medications which would help her deliver a HIV negative baby, can the baby contract the HIV through her breast milk?
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An alternate cure for AIDS?

Is is possible to cure AIDS patients by using white blood cells of blood cancer, by fooling HIV to attack a false target? Is it possible to wrap HIV in a physical boundary, such that it has no ...
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Can people with AIDS get a fever?

It's my understanding that fevers are an immune system response to infection. Like the body's cells can take more heat than most viruses or bacteria. So if that's the case then can you even get a ...
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Why is an HIV infection considered “incurable”?

My biology teacher told me that if one caught HIV, they cannot be cured because it was near to impossible to be completely virus-free. She said this was because HIV keeps on changing its glycoprotein ...
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Can the RNA in the HIV virus make viral enzymes without entering the nucleus?

If the provirus was not formed yet, can the virus make viral enzymes? (I know that it already has some, but supposing it doesn't)
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HIV and T helper cells

As far as I know and could understand from reading about HIV, T helper cell is one of the main reasons to develop AIDS in patients infected with HIV virus, that because the absence of helper T cell ...
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Reasons for the HIV-1 epidemic

So, the HIV-1 jump to humans occurred as early as the 1920s, but the AIDS epidemic didn't start until the early 1980s. Some things I don't understand about this: Why the delay? What is needed for a ...
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Is there a way to prevent an HIV infection after exposure to HIV infected Blood?

If a person is accidentally injected with blood from an HIV+ person, is there a treatment option that can keep the person from developing an HIV infection?
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Can HIV mutate to become airborne?

HIV has a very high mutation rate due to its inability to correct errors in DNA replication and it is very adaptable to its environment. Hence I wonder whether is it possible for it to mutate such ...
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Can we use the HIV antibody test to detect HIV in newborns? [closed]

Adults and elder children can use HIV rapid test to test HIV infection. Can we use the HIV antibody test to detect HIV in newborns too?
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HIV Rapid Tests

The hiv antigens that are used in the oral rapid tests, are they infectious? The tests do not contain any actual virus but I am curious if the antigens themselves could somehow create the virus on ...
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Why AZT is selective towards HIV and doesn't impair human DNA replication?

I've found this article, which is a very old one (from the time when nucleoside analogs where researched as a possible way to prevent replication of virus genetic material, before the HIV epidemics). ...
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How does HIV mutate into other strains while keeping their virulent phenotype?

How does a virus like HIV mutate into so many strains, and yet all of them are harmful to our immune system? What gives this virus the ability to mutate so efficiently?
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How Circumcision could reduce the chance for a HIV infection?

Circumcision removes the foreskin of the penis which mainly acts as a cover to the penis. Normally removing the foreskin makes more vulnerable to any STD, so how could circumcision reduce the risk of ...
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Reasons why people say that AIDS/HIV doesn't exist

It's been recurrent when I hear people saying that AIDS doesn't exist. When I ask why, they give weird reasons like HIV is a virus created to control economy and to develop medicine, etc. Also when I ...
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HIV and effectiveness of inhibitor cocktail over single inhibitor

I'm looking for clarification on the answer to this question. It's in my biochemistry class but I figured this is more Biology than Chemistry, so I'm asking it here. The question is: One of the ...
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Why HIV patients have greater virulence of M.tuberculosis?

I am reading Murray Microbiology book. Some facts M. tuberculosis is an intracellular pathogen. At the time of exposure, M. tuberculosis enters the respiratory airways and infectious particles ...
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It is possible for person with AIDS be negative for HIV antibodies?

I'm just curious as there was a bit controversy around this topic. It is possible for person with AIDS be negative for HIV antibodies? As of 1989, the CDC reported that 5% of all U.S. AIDS patients ...
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Is there a strong reason to be sceptical about the “cured HIV patient” being reported by mainstream media?

There's a story going round the news about a baby that was, apparently, cured of HIV using a cocktail of drugs at an early age. The story piqued my interest, but details seem scarce. One of the main ...
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Is it possible to get infected with HIV from old blood?

Let's say that someone uses a needle which has some old blood infected with HIV. In this case, is it possible for them to get infected with HIV?
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Can HIV be transmitted via breastfeeding?

If a pregnant women is HIV positive and she is treated with medicines to deliver a normal child,can she transfer the HIV virus back to her normal HIV free child by colostrum?
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Can a person be infected with HIV viruses without contacting them by person-related stuffs? [duplicate]

We know that a person can be infected with HIV viruses when he/she has sexual relationship with those having HIV viruses (and very, very, very rarely, urine/defecation-related transmission) - but I ...
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Are there people cured of HIV by means of HAART?

I wonder if there people who were cured of HIV only by means of highly active anti retro-viral therapy (HAART) or other drugs rather than by bone marrow transplant? I know that HAART can suppress HIV ...
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Is this a valid principle of curing HIV?

I have a set of questions actually, it will be very helpful if you answer them in order. Where does the HIV virus hide (during incubation period)? Let answer be X cell. Is X cell in the bloodstream? ...
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Which is harder to contract - HIV or AIDS?

I am working on mathematically modeling HIV and Tuberculosis Co-infection dynamics, and am working with 12 differential equations describing the behavior of all of the compartments and parameters. ...
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HIV-RT nucleotide contact residues

I'm investigating HIV-RT 3KLF and 1LWF trying to find a perfect pose of thymine. Which residues on HIV-RT is Thymine supposed to contact on 3KLF and 1LWF? Where exactly is the nucleotide binding ...
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qrt-pcr and short fragments

I plan to measure the effects of Tenofovir a Nucleotide analog reverse-transcriptase inhibitors useing qrt-pcr with HIV-RT as the rt enzyme. Tenofovir causes early termination of the reverse ...
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Are homozygous carriers of the CCR5-Δ32 allele fully immune to all known strains of HIV?

Or is there documented evidence of even one homozygous carrier contracting HIV and staying infected?
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How does herpes (HSV) infection suppress HIV?

HIV compromises the human body to defend against infection. Yet people who are infected with herpes are at less risk of developing AIDS. How does this work?
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Why human body cannot defend against HIV? [closed]

Some says that HIV destroy IRF3, and some says HIV overruns T-cells.