The scientific study of inheritance as it occurs specifically in human beings.

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How to search for all human diseases associated with a inversion on chromosome 22?

I know that a deceased relative had a genetic test made that showed a result of a Chromosomal inversion on chr22 but I don't know what type and where is the inversion until I get the full medical ...
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26 views

Genetics behind Preimplantation genetic diagnosis (PGD) [on hold]

Preimplantation genetic diagnosis (PGD) is a screening test used to determine if genetic or chromosomal disorders are present in embryos produced through in vitro fertilization ...
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38 views

How big advantage had a trait have to bring to evolve in the human evolution? [on hold]

Yes, I've heard that we have evolved from the common ancestor with primates as intesively, as the chimpanzees. Sometimes I read about some enormously complex traits, evolutionary psychologists think ...
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34 views

How can I get my DNA tested without the results being kept by third-party? [migrated]

Mainly I'm interested in getting to know my ancestry, but I don't mind doing a lot of research on my own to classify it if I get raw results. The thing that I do not want is my DNA being stored ...
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36 views

Is human regeneration possible? [closed]

A lizard has the ability to regenerate its tail. Is it possible by genetics to use this property on a human who is handicapped to regenerate their hand? Has this ever been tried in the past? Will the ...
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21 views

What the gene variation detection result can tell us about a cancer [duplicate]

We do a research on a particular cancer, now we have a result of the gene variation detection . What next steps do we need to do? we don't have a clear picture about this. Can you give us some ...
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32 views

An elementary question for gene variation detection procedure in a paper

“Samples were divided into subtypes; each subtype was considered separately as a test set, using the remaining subtypes as the control. In our analysis, chromosome arms were subdivided into ...
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18 views

why penis is in erected state at the time of wokeup? [duplicate]

In morning wakeup we can observe that penis is in erected state in human physiology when we can observe these type of situations and why?
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2answers
66 views

Infer gene frequency within a species over time

I was reading Karlsson et al. (2014) and I came into this: A selected variant that increases rapidly in frequency in the past ~250,000 years can be detected as an unusual reduction in genetic ...
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18 views

Runs of homozygosity - degree of inbreeding and disease associations

Been reading recently about methods to determine how inbred a particular person is by measuring their "runs of homozygosity." Loosly, these are defined as regions of the genome (typically >1Mb) where ...
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1answer
50 views

Data on Gene Position in Human Genome

I am trying to get some data on gene position in the human genome and I need some help What I tried I downloaded ...
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1answer
41 views

Data on Recombination rate and Gene Positions in Humans

I am looking for estimates of per base pair recombination rate in humans and indication on gene positions. The goal is to be a able to plot recombination rate in the y-axis and position (in bp) along ...
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19 views

When sperm and egg mix, are the genes rearranged? [closed]

I remember once my high school teacher said when the sperm fertilizes the egg the genes are mixed very randomly, is that true?
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28 views

How Did They Know What To Do ? And Cellular Identification [closed]

So this is regarding Science, generally, it has influence throughout each section science. How did the early age Scientists etc. knew what is to be done to achieve a certain thing ? And by that, I ...
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1answer
19 views

Molecules, Targets and Isoforms

I have a question. Given a molecule A and two isoforms of a gene X, Y, and the knowledge that A targets X. Can I infere from this anything about whether A targets Y? As a motivation think about ...
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1answer
20 views

Unwanted E. coli product in plasmid product

Using a TOPO XL Cloning kit, our lab took some amplified human DNA, inserted it into the vector, and attempted to clone it in E. coli. However, upon sequencing the purified plasmid product, the ...
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1answer
48 views

Is it common to have multiple recessive traits in humans?

I just started thinking about my phenotype and realized I got multiple recessive traits. I have attached ear lobes, my blood type is O-, I got green eyes (I think eye color in polygenic but still ...
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19 views

Why is down syndrome more common than other trisomies? [duplicate]

Why is Down syndrome more common than say trisomy 18? Is chromosome 21 easier to replicate? Or is it because those babies are more viable?
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1answer
26 views

Irradiation positive effect on humans?

In research paper Euphytica 135: 187–204, 2004 it is written that: 434 mutant varieties of rice have been released with improved characters such as semi-dwarf height, early maturity, improved ...
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18 views

How to estimate the average improvement of the value of a phenotypic trait in an improved environment?

Let us assume there is a population and two environments x(good) and y(bad) on average those members of the population born and raised in the former environment show higher scores than the latter. ...
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2answers
62 views

Basic Genotyping

As a disclaimer, I'm from a computer science / statistics background, working on some bioinformatics problems. I've got some genotyping data (VCF from Exome Sequencing), and I'm struggling to get my ...
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68 views

What causes the range of severity of neurological deficits in Down's syndrome?

It's known that the severity of symptoms caused by a trisomy 21 varies from individual to individual. Part of the explanation for this range of severity is the finding that 94% of Down's syndrome ...
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31 views

How should one interpret heritability? Is it related to $R^2$?

From Wiki: Heritability estimates are often misinterpreted if it is not understood that they refer to the proportion of variation between individuals on a trait that is due to genetic factors. It ...
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2answers
185 views

Is the DNA different in each type of cell? What DNA is passed to offspring?

Our body contains many different types of cells and each of those cells have their own DNA (correct me if wrong) like skin cells their own DNA that makes them skin cells instead of muscle cells. So ...
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1answer
25 views

“Heterozygotic expection” - when heterozygote differs from both homozygotes, but homozygotes are similar

For simple 2-alleles genetic model {a,A} and corresponding quantitative trait Q is typically true that Q(aa)>=Q(aA)>=Q(AA) or conversely Q(AA)>=Q(aA)>=Q(aA). For example, dominance means that ...
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30 views

How much genetic divergence must there be to yield two different species? [duplicate]

I read that humans are a few percent Neanderthal. So how much difference between egg and sperm is needed for there to be no offspring. That is, for there to be two different species? Is this a ...
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214 views

Why are the genomes of Humans 99.5% the same?

Human's DNA sequence is said to be roughly 99.5% equal. As far as I understand, this means that if I walked up to you and compared our DNA, the sequence of base pairs would be 99.5% the same. My ...
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What would the resulting karyotype be if someone with Klinefelter syndrome fertilized an “empty” egg?

Endoreduplication: is a form of nuclear polyploidization that results in multiple, uniform copies of chromosomes. This process is common in plants and animals, especially in tissues with high ...
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33 views

Is it possible to have raw ngs data to practice

I'm looking for raw human ngs data to practice in bioinformatics. Better if it is from different machines (illumina, roche, pacsbio, etc). Panels, exomes and genomes. Anyone knows something?
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13 views

heterolog bodysites development?

Would it actually be possible due to unhomogen distribution of growth factors in the growth of an embryo to develop conditions like Polydactyly only on one side of the body or in an even stranger ...
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1answer
314 views

What does it mean to have a Y-DNA Haplogroup “R-M512”? [closed]

I did a DNA test to learn about my origins, but the results are highly technical. I see I have a Y-DNA Haplogroup R-M512 and a mutation (zero marker in DYS448). I Googled these terms and came across ...
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1answer
86 views

What does it mean to clone a gene?

When I look up information related to the identification of disease genes, texts will often refer to the gene being "first cloned." What does "clone" mean in this context? Is it simply a synonym for ...
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69 views

Prader-Willi Syndrome and Angelman Syndrome?

On the website http://www.whatisepigenetics.com/fundamentals/2/ it states that the imprint disorders Prader-Willi syndrome and Angelman syndrome, display an abnormal phenotype as a result of the ...
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1answer
47 views

Inheritance patterns in individuals with triploidy

If you search on the genetics of Down's Syndrome, you'll find plenty of results explaining the genetic mechanisms which can result in triploidy. However, I can't find any information on the ...
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49 views

How to find name of the gene

Considering the kegg page, this page contains the description of the gene Edwardsiella tarda EIB202: ETAE_0074 . Now this gene has a name given in the page as : wabG. Now considering another gene 1 ...
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1answer
48 views

Human Endogenous Retroviruses

I am reading this paper, which shows that a Human Endogenous Retrovirus (HERV) K provirus is present at the orthologous position of gorilla and chimpanzee genomes but absent in the human genome. If ...
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1answer
93 views

Have there been any “chopstick gene” mistakes in genetics? [closed]

I've heard of the "chopstick gene" fallacy - wrongly assuming an association between genetics and some characteristic, confounded by non-genetic factors. Has this fallacy happened in real life? I'm ...
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2answers
49 views

Do eukaryote cells contain DNA that isn't part of a chromosome or located in the mitochondria?

I specify eukaryote in the title, but I'm also interested if this question isn't applicable to eukaryote cells in general but is to humans. I was reading "RNA-seq: An assessment of technical ...
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2answers
64 views

When did human ancestors learn to walk? [closed]

Where does our ancestor learn to walk from? How do we control our legs whenever we take a step? I confuse every time whenever I take one step.
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1answer
100 views

Where in the world does blue eyed whites originate from?

I know that there were no blue eyed people until ~6000 years ago due to a mutation and all blue eyed people have a single common anchestor. But where in the world does it originate? I assume it ...
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15 views

Serotonin activity with short 5-HTT promotor region and depression

So after reading a few studies (1,2) it seems that a shorter promotor region for the serotonin transport protein may be associated with increased likelihood of developing depression after stressful ...
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127 views

Why do my 23andme results only show me as 8.2% Scandinavian? [closed]

I just got my 23andme results back. My paternal grandfather was full Swedish. Shouldn't that make me 25% Swedish? 23andme tells me I'm only 8.2% Scandinavian. Or maybe my father inherited less than ...
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30 views

Will someone with a double mutation in the allosomes be normal?

Normally a female human has an X allosome from her father and an X allosome form her mother. What if an double mutation happened, which causes that someone has two X allosomes form her mother and no ...
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2answers
116 views

how do I find the number of bp in chromosome 3 by knowing number of bp in chromosome 1?

If i have a number of bp in chromosome 1 for example(298,295,559 bp) can I use this number to find the number of bp in chromosome 3.
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1answer
122 views

What percentage of people today would likely be descendants a man born 4,000 years ago?

Assuming a particular man was born in southern Mesopotamia, around 4,000 years ago, and was significant involved in a major religion. To what degree (if any) of accuracy could his descendants be ...
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1answer
31 views

IBD-value and IBD-fraction

I have some questions about the IBD-value and IBD-fraction for two of the condensed identity states, $S_1$ and $S_7$. My questions: 1) Is the IBD-value for the individuals i and j two (2) in $S_1$ ...
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25 views

Genetic component to the location of acquired nevi (moles) on humans?

One of my sons, currently age 4, who was (as is typical) born without moles, has begun to develop them (as is also typical). I noticed that his largest mole is in practically the exact same location ...
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125 views

Do transposons usually jump from one chromosome to another?

If it is usual occurrence, does it mean that my one gene can change its location from one chromosome to another?
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1answer
45 views

Genetics of epilepsy

Is epilepsy genetically inheritable? If yes, is it dominant?
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54 views

In what way is ADHD genetic? [closed]

According to Psychcentral depression, bipolar disorder, ADHD, schizophrenia and autism are traceable to the same inherited genetic variations According to AsapSCIENCE, depression could be genetic due ...