The scientific study of inheritance as it occurs specifically in human beings.

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Robertsonian translocation on the same chromosome

is there any big difference between Robert-son-i-an translocation between two 13 chromosomes comparing to a translocation between 13 and 14 chromosomes
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78 views

How Much DNA do Siblings whose Parents are First Cousins Share?

On average, two siblings generally share 50% of their genome. How much does this increase if the siblings' parents are first cousins?
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23 views

Is brachydactyly due to mutation?

I have this so called "clubbed thumbs"also known as brachydactyly. It is of D-type. I searched for it on internet and found that it is a dominant inherited disease. But to my surprise,none of my ...
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63 views

Is it possible to have raw ngs data to practice

I'm looking for raw human ngs data to practice in bioinformatics. Better if it is from different machines (illumina, roche, pacsbio, etc). Panels, exomes and genomes. Anyone knows something?
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17 views

Genetic screening understanding requisites

I am a mathematics and philosophy undergraduate student studying a bit of a biology as part of a philosophy research project on genetic screening. I have not studied biology since I was 16 and I was ...
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1answer
45 views

ExAC Browser: What does a “dubious variant annotation” actually mean? [closed]

I wonder how a "dubious" variant annotation is exactly defined in ExAC. I couldn't find any further information neither at the variant's page nor in the FAQs. Link to ExAC browser. Link to variant ...
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40 views

Why was the study of “Concordance of Monozygotic and Dizygotic twins for traits” designed in this way? [closed]

I am confused by the twin study 'Concordance of Monozygotic and Dizygotic twins for traits.' My questions arose from 3:17-4:17 of the video And this is the related data I have referred I have ...
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1answer
78 views

How do heredity and regression to the mean work with respect to intelligence?

I am trying to understand the heredity of intelligence between generations in general, and how regression to the mean works in detail in particular. The answer I'm looking for should preferably answer ...
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1answer
73 views

What percentage of a Neanderthal's DNA could be in a Denisovan?

My questions arose from an online course video at 3:11-19 The professor mentioned that the Neanderthals were inbred with their cousins breeding together but the Denisovans were very diverse , with 70%...
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21 views

Hybridization of an Indo-Aryan ethnic group and a Tibeto-Burmese ethnic group

The state in which I reside houses these two distinct ethnic groups. Physical Traits of the Indo-Aryan group Height:Medium Eyes:does not posses epicanthic fold Nasal bones:is not flat and broad ...
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1answer
55 views

Perplexing by the way of estimating the shared or different genes between humans and chimps

We share 98.5% genes with chimps (it means we have 98.5% same DNA sequeces ),so there is about one percent difference .It means we can approximately differ from them by one base pair every hundred ...
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86 views

How valid is the theory of human's chimp-pig origin? [closed]

Edit: I have also asked the question on skeptics.stackexchange.com and it has been answered there. Here is the link. There is a person called Dr. Eugene McCarthy who has a theory that the origin of ...
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19 views

What does high level science actually say about the gay gene? [duplicate]

There is a lot of talk about genetics in the contemporary debate on the morality of homosexual behavior (and bisexual behavior, hereafter implied). As I understand the issue, the thought is not that ...
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1answer
85 views

How likely is it that a person's progeny has an inheritable disorder based on this pedigree?

Case study: A person (let's just call him "John") had 3 aunts that died back in the 1950's in early childhood due to an unknown form of neuromuscular disorder. One died at birth, one at 2 years and ...
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2answers
107 views

What are sex linked traits?

Which of the two definitions of sex-linked trait is correct? Traits controlled by genes present on the non-homologous region of sex chromosomes are called sex-...
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1answer
43 views

What are silent carrier traits? [closed]

I couldn't find a definition but I have come to know the following from google search: People who are carriers of a thalassemia gene show no thalassemia symptoms and might not know they're ...
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20 views

Links between Genetics and Personality Types

This topic was visited briefly in the thread, Genetic Effects on Personality, but I was surprised not to find more on it. (Is there a taboo I don't know about? What's the ethical stance on this ...
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1answer
56 views

autosomal recessive population numbers

This question is background research for a science fiction / fantasy novel, my knowledge of genetic is very basic. It seems obvious to me that for genetic disorders that are autosomal recessive, if ...
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1answer
66 views

How do harsh conditions cause an increase in the male birth ratio?

I've heard that in harsh conditions more human baby boys are born than girls because a bigger ratio of them will die before reproductive age. But in which aspects of the random gene combination while ...
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1answer
105 views

What is the difference between a Human Being, Homo Sapiens and a Neanderthal?

I know that the Neanderthal's are a branch of the Human Being but how do all three relate to each other or more specifically what is the difference?
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194 views
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How to search for all human diseases associated with a inversion on chromosome 22?

Is there any way to search for all diseases that associated with inversions on chr22? I found some online research databases like OMIM and disgenet but I don't know the correct nomenclature on how to ...
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3answers
191 views

Swapping genes?

So, gene therapy is to take out a gene, correct its mutation, and put the corrected one back into the organism, right? Is it also possible to take out a gene from an organism and put in a totally ...
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1answer
4k views

Why are men stronger than women?

What are the evolutionary explanations for why women are physically weaker than men (on average), and is this difference adaptive? See figure one here. I suppose that something puts pressure on men ...
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1answer
45 views

How big advantage had a trait have to bring to evolve in the human evolution? [closed]

Yes, I've heard that we have evolved from the common ancestor with primates as intesively, as the chimpanzees. Sometimes I read about some enormously complex traits, evolutionary psychologists think ...
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32 views

An elementary question for gene variation detection procedure in a paper

“Samples were divided into subtypes; each subtype was considered separately as a test set, using the remaining subtypes as the control. In our analysis, chromosome arms were subdivided into ...
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22 views

What the gene variation detection result can tell us about a cancer [duplicate]

We do a research on a particular cancer, now we have a result of the gene variation detection . What next steps do we need to do? we don't have a clear picture about this. Can you give us some ...
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56 views

Data on Gene Position in Human Genome

I am trying to get some data on gene position in the human genome and I need some help What I tried I downloaded ...
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2answers
72 views

Infer gene frequency within a species over time

I was reading Karlsson et al. (2014) and I came into this: A selected variant that increases rapidly in frequency in the past ~250,000 years can be detected as an unusual reduction in genetic ...
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18 views

why penis is in erected state at the time of wokeup? [duplicate]

In morning wakeup we can observe that penis is in erected state in human physiology when we can observe these type of situations and why?
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29 views

Runs of homozygosity - degree of inbreeding and disease associations

Been reading recently about methods to determine how inbred a particular person is by measuring their "runs of homozygosity." Loosly, these are defined as regions of the genome (typically >1Mb) where ...
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1answer
48 views

Data on Recombination rate and Gene Positions in Humans

I am looking for estimates of per base pair recombination rate in humans and indication on gene positions. The goal is to be a able to plot recombination rate in the y-axis and position (in bp) along ...
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52 views

Would it be possible to create a gel, holding viruses, that could alter the human genome when rubbed in?

I was wondering if it could be possible to engineer a virus, that when it comes into contact with human hair follicles, it could alter someones natural hair color. Naturally blue hair anyone? ...
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1answer
29 views

What do we use as baseline to determine what genetic segments are “mutations” (and what are not)

In order to determine whether a particular segment of the genome is a mutation, there must first be a baseline code on which that code looks somehow different. How has the baseline genome been ...
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Basic Genotyping

As a disclaimer, I'm from a computer science / statistics background, working on some bioinformatics problems. I've got some genotyping data (VCF from Exome Sequencing), and I'm struggling to get my ...
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When sperm and egg mix, are the genes rearranged? [closed]

I remember once my high school teacher said when the sperm fertilizes the egg the genes are mixed very randomly, is that true?
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1answer
59 views

Is it common to have multiple recessive traits in humans?

I just started thinking about my phenotype and realized I got multiple recessive traits. I have attached ear lobes, my blood type is O-, I got green eyes (I think eye color in polygenic but still ...
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13k views

Will a bone marrow transplant change one's blood type?

Will a bone marrow transplant change one's blood type? Or is the donor blood type matched with the person before transplant?
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48 views

Which disorders are fully concordant?

I work in neuroscience, mostly Alzheimer's disease (AD), with some work in autism spectrum disorder (ASD). The work is in gene regulation and epigenomics. I'm familiar with monozygotic twin (MZ) ...
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How Did They Know What To Do ? And Cellular Identification [closed]

So this is regarding Science, generally, it has influence throughout each section science. How did the early age Scientists etc. knew what is to be done to achieve a certain thing ? And by that, I ...
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1answer
19 views

Molecules, Targets and Isoforms

I have a question. Given a molecule A and two isoforms of a gene X, Y, and the knowledge that A targets X. Can I infere from this anything about whether A targets Y? As a motivation think about ...
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1answer
21 views

Unwanted E. coli product in plasmid product

Using a TOPO XL Cloning kit, our lab took some amplified human DNA, inserted it into the vector, and attempted to clone it in E. coli. However, upon sequencing the purified plasmid product, the ...
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778 views

Why has grey hair evolved?

A vast majority of humans get at least some grey hair as they age. As far as I know this applies to both genders and all races. Presumably this means that at least some grey haired humans have ...
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Why is down syndrome more common than other trisomies? [duplicate]

Why is Down syndrome more common than say trisomy 18? Is chromosome 21 easier to replicate? Or is it because those babies are more viable?
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27 views

Irradiation positive effect on humans?

In research paper Euphytica 135: 187–204, 2004 it is written that: 434 mutant varieties of rice have been released with improved characters such as semi-dwarf height, early maturity, improved ...
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How to estimate the average improvement of the value of a phenotypic trait in an improved environment?

Let us assume there is a population and two environments x(good) and y(bad) on average those members of the population born and raised in the former environment show higher scores than the latter. ...
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3answers
14k views

Is it possible for a child to grow taller than their tallest parent?

I have heard that offspring can't grow taller than either of their parents but I've also heard that sometimes some gene activation can skip generations. Is it possible for a child to grow taller than ...
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What causes the range of severity of neurological deficits in Down's syndrome?

It's known that the severity of symptoms caused by a trisomy 21 varies from individual to individual. Part of the explanation for this range of severity is the finding that 94% of Down's syndrome ...
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1answer
55 views

Inheritance patterns in individuals with triploidy

If you search on the genetics of Down's Syndrome, you'll find plenty of results explaining the genetic mechanisms which can result in triploidy. However, I can't find any information on the ...
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Is the DNA different in each type of cell? What DNA is passed to offspring?

Our body contains many different types of cells and each of those cells have their own DNA (correct me if wrong) like skin cells their own DNA that makes them skin cells instead of muscle cells. So ...