The scientific study of inheritance as it occurs specifically in human beings.

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autosomal recessive population numbers

This question is background research for a science fiction / fantasy novel, my knowledge of genetic is very basic. It seems obvious to me that for genetic disorders that are autosomal recessive, if ...
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10 views

how to explain the results from conditional analysis [closed]

Some SNPs are not significant in the original GWAS associated data. I hope to find the causal SNP and the independent SNPs by running conditional analysis( top SNP as the covariance,regression ...
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1answer
61 views

How do harsh conditions cause an increase in the male birth ratio?

I've heard that in harsh conditions more human baby boys are born than girls because a bigger ratio of them will die before reproductive age. But in which aspects of the random gene combination while ...
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58 views

What is the difference between a Human Being, Homo Sapiens and a Neanderthal?

I know that the Neanderthal's are a branch of the Human Being but how do all three relate to each other or more specifically what is the difference?
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185 views
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28 views

How to search for all human diseases associated with a inversion on chromosome 22?

Is there any way to search for all diseases that associated with inversions on chr22? I found some online research databases like OMIM and disgenet but I don't know the correct nomenclature on how to ...
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3answers
184 views

Swapping genes?

So, gene therapy is to take out a gene, correct its mutation, and put the corrected one back into the organism, right? Is it also possible to take out a gene from an organism and put in a totally ...
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3k views

Why are men stronger than women?

What are the evolutionary explanations for why women are physically weaker than men (on average), and is this difference adaptive? See figure one here. I suppose that something puts pressure on men ...
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41 views

How big advantage had a trait have to bring to evolve in the human evolution? [closed]

Yes, I've heard that we have evolved from the common ancestor with primates as intesively, as the chimpanzees. Sometimes I read about some enormously complex traits, evolutionary psychologists think ...
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34 views

How can I get my DNA tested without the results being kept by third-party? [migrated]

Mainly I'm interested in getting to know my ancestry, but I don't mind doing a lot of research on my own to classify it if I get raw results. The thing that I do not want is my DNA being stored ...
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32 views

An elementary question for gene variation detection procedure in a paper

“Samples were divided into subtypes; each subtype was considered separately as a test set, using the remaining subtypes as the control. In our analysis, chromosome arms were subdivided into ...
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22 views

What the gene variation detection result can tell us about a cancer [duplicate]

We do a research on a particular cancer, now we have a result of the gene variation detection . What next steps do we need to do? we don't have a clear picture about this. Can you give us some ...
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54 views

Data on Gene Position in Human Genome

I am trying to get some data on gene position in the human genome and I need some help What I tried I downloaded ...
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2answers
69 views

Infer gene frequency within a species over time

I was reading Karlsson et al. (2014) and I came into this: A selected variant that increases rapidly in frequency in the past ~250,000 years can be detected as an unusual reduction in genetic ...
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18 views

why penis is in erected state at the time of wokeup? [duplicate]

In morning wakeup we can observe that penis is in erected state in human physiology when we can observe these type of situations and why?
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20 views

Runs of homozygosity - degree of inbreeding and disease associations

Been reading recently about methods to determine how inbred a particular person is by measuring their "runs of homozygosity." Loosly, these are defined as regions of the genome (typically >1Mb) where ...
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43 views

Data on Recombination rate and Gene Positions in Humans

I am looking for estimates of per base pair recombination rate in humans and indication on gene positions. The goal is to be a able to plot recombination rate in the y-axis and position (in bp) along ...
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52 views

Would it be possible to create a gel, holding viruses, that could alter the human genome when rubbed in?

I was wondering if it could be possible to engineer a virus, that when it comes into contact with human hair follicles, it could alter someones natural hair color. Naturally blue hair anyone? ...
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29 views

What do we use as baseline to determine what genetic segments are “mutations” (and what are not)

In order to determine whether a particular segment of the genome is a mutation, there must first be a baseline code on which that code looks somehow different. How has the baseline genome been ...
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65 views

Basic Genotyping

As a disclaimer, I'm from a computer science / statistics background, working on some bioinformatics problems. I've got some genotyping data (VCF from Exome Sequencing), and I'm struggling to get my ...
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1answer
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When sperm and egg mix, are the genes rearranged? [closed]

I remember once my high school teacher said when the sperm fertilizes the egg the genes are mixed very randomly, is that true?
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Is it common to have multiple recessive traits in humans?

I just started thinking about my phenotype and realized I got multiple recessive traits. I have attached ear lobes, my blood type is O-, I got green eyes (I think eye color in polygenic but still ...
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12k views

Will a bone marrow transplant change one's blood type?

Will a bone marrow transplant change one's blood type? Or is the donor blood type matched with the person before transplant?
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48 views

Which disorders are fully concordant?

I work in neuroscience, mostly Alzheimer's disease (AD), with some work in autism spectrum disorder (ASD). The work is in gene regulation and epigenomics. I'm familiar with monozygotic twin (MZ) ...
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28 views

How Did They Know What To Do ? And Cellular Identification [closed]

So this is regarding Science, generally, it has influence throughout each section science. How did the early age Scientists etc. knew what is to be done to achieve a certain thing ? And by that, I ...
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Molecules, Targets and Isoforms

I have a question. Given a molecule A and two isoforms of a gene X, Y, and the knowledge that A targets X. Can I infere from this anything about whether A targets Y? As a motivation think about ...
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Unwanted E. coli product in plasmid product

Using a TOPO XL Cloning kit, our lab took some amplified human DNA, inserted it into the vector, and attempted to clone it in E. coli. However, upon sequencing the purified plasmid product, the ...
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686 views

Why has grey hair evolved?

A vast majority of humans get at least some grey hair as they age. As far as I know this applies to both genders and all races. Presumably this means that at least some grey haired humans have ...
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Why is down syndrome more common than other trisomies? [duplicate]

Why is Down syndrome more common than say trisomy 18? Is chromosome 21 easier to replicate? Or is it because those babies are more viable?
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26 views

Irradiation positive effect on humans?

In research paper Euphytica 135: 187–204, 2004 it is written that: 434 mutant varieties of rice have been released with improved characters such as semi-dwarf height, early maturity, improved ...
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How to estimate the average improvement of the value of a phenotypic trait in an improved environment?

Let us assume there is a population and two environments x(good) and y(bad) on average those members of the population born and raised in the former environment show higher scores than the latter. ...
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12k views

Is it possible for a child to grow taller than their tallest parent?

I have heard that offspring can't grow taller than either of their parents but I've also heard that sometimes some gene activation can skip generations. Is it possible for a child to grow taller than ...
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What causes the range of severity of neurological deficits in Down's syndrome?

It's known that the severity of symptoms caused by a trisomy 21 varies from individual to individual. Part of the explanation for this range of severity is the finding that 94% of Down's syndrome ...
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Inheritance patterns in individuals with triploidy

If you search on the genetics of Down's Syndrome, you'll find plenty of results explaining the genetic mechanisms which can result in triploidy. However, I can't find any information on the ...
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224 views

Is the DNA different in each type of cell? What DNA is passed to offspring?

Our body contains many different types of cells and each of those cells have their own DNA (correct me if wrong) like skin cells their own DNA that makes them skin cells instead of muscle cells. So ...
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39 views

How should one interpret heritability? Is it related to $R^2$?

From Wiki: Heritability estimates are often misinterpreted if it is not understood that they refer to the proportion of variation between individuals on a trait that is due to genetic factors. It ...
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“Heterozygotic expection” - when heterozygote differs from both homozygotes, but homozygotes are similar

For simple 2-alleles genetic model {a,A} and corresponding quantitative trait Q is typically true that Q(aa)>=Q(aA)>=Q(AA) or conversely Q(AA)>=Q(aA)>=Q(aA). For example, dominance means that ...
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123 views

What percentage of people today would likely be descendants a man born 4,000 years ago?

Assuming a particular man was born in southern Mesopotamia, around 4,000 years ago, and was significant involved in a major religion. To what degree (if any) of accuracy could his descendants be ...
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30 views

How much genetic divergence must there be to yield two different species? [duplicate]

I read that humans are a few percent Neanderthal. So how much difference between egg and sperm is needed for there to be no offspring. That is, for there to be two different species? Is this a ...
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237 views

Why are the genomes of Humans 99.5% the same?

Human's DNA sequence is said to be roughly 99.5% equal. As far as I understand, this means that if I walked up to you and compared our DNA, the sequence of base pairs would be 99.5% the same. My ...
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93 views

Have there been any “chopstick gene” mistakes in genetics? [closed]

I've heard of the "chopstick gene" fallacy - wrongly assuming an association between genetics and some characteristic, confounded by non-genetic factors. Has this fallacy happened in real life? I'm ...
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12k views

Do humans have enough biological differences to be grouped into races or subspecies?

After my online research on the subject, I learnt that, biologically speaking, many scientists believe that there is no such thing as a race. Homo sapiens as a species is only 200,000 years old, which ...
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512 views

How does a fetus retain a blood group different from its mother?

It's a well-established fact that blood group is decided by genotype. But, when a new child starts its journey in the womb, the mother's blood (along with it's agglutinins and agglutinogens) flows ...
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20 views

What would the resulting karyotype be if someone with Klinefelter syndrome fertilized an “empty” egg?

Endoreduplication: is a form of nuclear polyploidization that results in multiple, uniform copies of chromosomes. This process is common in plants and animals, especially in tissues with high ...
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2k views

The Uniqueness of DNA Paradox

How can everyone have unique iris and fingerprints? After a certain amount of human beings have lived on earth, wouldn't it be possible to exhaust all possible combinations? The same principle ...
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Is there a realistic “family tree” model for the human population?

I would like to do some gene inheritance simulations, and I was wondering if there is an accepted model for what mating looks like in the general human population? I am not necessarily looking for the ...
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Prader-Willi Syndrome and Angelman Syndrome?

On the website http://www.whatisepigenetics.com/fundamentals/2/ it states that the imprint disorders Prader-Willi syndrome and Angelman syndrome, display an abnormal phenotype as a result of the ...
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33 views

Is it possible to have raw ngs data to practice

I'm looking for raw human ngs data to practice in bioinformatics. Better if it is from different machines (illumina, roche, pacsbio, etc). Panels, exomes and genomes. Anyone knows something?
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Why do we assume that the first humans were dark-skinned?

According to the article Dark skin and blue eyes: How Europeans once looked: It is widely accepted that Man's oldest common forefather was dark skinned, and that people became more pale as they ...
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386 views

What does it mean to have a Y-DNA Haplogroup “R-M512”? [closed]

I did a DNA test to learn about my origins, but the results are highly technical. I see I have a Y-DNA Haplogroup R-M512 and a mutation (zero marker in DYS448). I Googled these terms and came across ...