Tagged Questions

The scientific study of inheritance as it occurs specifically in human beings.

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1answer
63 views

How do I figure out which of the valleys I came from?

I had my DNA tested by 23andme.com. They give me a very long string for my DNA. How do I determine which of the three Ethiopian valleys I descended from? I'm of European descent. ...
1
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1answer
132 views

Is it really detrimental to humans as a species to reproduce with one's own first cousin?

Tired of hearing of these urban legends and popular opinions, I ask this question here to see if there really is scientific merit to this belief. My questions is, is it really "harmful" for a person ...
9
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1answer
104 views

Is there any evidence that humans have faced extinction before?

Have we as a species faced extinction in the past? Resulting in a 'population bottleneck'? If so, what genetic evidence is there of this occurring?
8
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1answer
426 views

Could humans and chimpanzees hybridize?

In some cases two species can hybridize. For example, Tigers and lions can hybridize to produce "Ligers". Would it also be possible for humans and chimpanzees (or any other species) to hybridize ? ...
2
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1answer
179 views

How do PLINK files and HapMap Phased files differ?

I know that PLINK and HapMap files show the same information, but can you give a thorough explanation of how exactly they differ.
2
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1answer
396 views

What do rs id, allele coded 0 and allele coded 1 mean?

So, for a project I've been working on (different story), I've been looking at the HapMap Project, and their free online files. In their README file, they talk about how for each legend file for each ...
2
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2answers
721 views

Are human males and females more genetically different than members of other species?

I'm looking at this Ted talk about a Saudi Arabia woman who dared to drive a car in the last few years. This reminds me that until the last century or so, women (all over the world?) enjoyed less ...
6
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3answers
159 views

Why are males more likely than females to have autism spectrum disorder?

The male to female ratio in autism spectrum disorder is around 4:1. However it seems ASD is not a simple X-linked disorder. Then how is it possible males are more susceptible than females, if the ...
5
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1answer
222 views

Would a spinal injury decrease human height?

A woman I know has been losing height at a rate of few cm a year following a severe spinal injury. How is this possible? What kind of injury could cause such progressive loss of height? Could this be ...
5
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1answer
159 views

Why are certain aneuploidies more common?

Certain aneuploidies such as trisomy-21 (Downs syndrome), trisomy-18 (Edward syndrome), Turner syndrome (XO) etc are more common than others. I had a vague thought that it is related to chromosome ...
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2answers
146 views

Hardy-Weinberg Equilibrium: To compute probability of finding two siblings (random mating)

I've been working a little with M. G. Bulmer's Principles of Statistics (Dover, 1979) and cannot see how to properly compute half of one question. This should be a basic probability computation, but I ...
3
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1answer
233 views

What factors govern the variable age of onset in Huntington's Disease?

"Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems." As we all know, this genetic disease ...
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1answer
70 views

Are there any studies of epigenetic difference between twins during their lifespan?

Are there any studies of epigenetic difference between twins during their lifespan ? I ask because I wonder if there exist phases during lifespan, when environmental factors plays major role ...
5
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1answer
171 views

What is a Mitochondrial Eve and Y-chromosomal Adam

I've read this question: What kind of event would cause the current Mitochondrial Eve to be replaced by a new one? And the values in Wikipedia about Mitochondrial Eve and Y-chromosomal Adam and I am ...
2
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1answer
105 views

Why do genitals feel frozen when freefalling?

I don't want to add much more about that. Since childhood I noticed a chilling effect, even when doing rollercoaster-type activities.
3
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1answer
80 views

Regeneration capabilities in humans?

To what extent can humans, (mammals in general), theoretically regenerate, and is their a way to speed up and/or exceed this original extent.
13
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2answers
2k views

How many people are required to maintain genetic diversity?

Imagine humans were to colonize a distant planet and it was a single one-way trip. How many people would they need to bring? Obviously 2 is the minimum, but that would result in a lot of inbreeding. ...
8
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3answers
267 views

What kind of event would cause the current Mitochondrial Eve to be replaced by a new one?

Apparently all living humans are matrilineal descendants of a single woman who lived 200.000 years ago. She is called Mitochondrial Eve. But at the time she lived there was a different matrilineal ...
6
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1answer
7k views

Will a bone marrow transplant change one's blood type?

Will a bone marrow transplant change one's blood type? Or is the donor blood type matched with the person before transplant?
2
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1answer
92 views

Have there been any experiments that duplicate chromosome copies from 23*2 to 23*3 or 23*4?

Deinococcus radiodurans is an amazing bacterium with a fantastic survival rate. It can survive to high doses of radiation, in a complete vacuum and in hydrochloric acid. How does this bacterium ...
2
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1answer
48 views

PGC-1β Sod2 limiters/blockers

I'd like to block a percentage of PGC-1β or Sod2 expression. According to the following paper's figure beta-blockers inhibit some expression of PGC-1α. Are there any medicines/chemicals which safely ...
2
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2answers
133 views

Is better healthcare a bane to the long-term survival of the human race?

The theory of natural selection has it that individuals with better genes tend to survive and reproduce, passing their genes to their offspring. This gradual process results in a population more ...
6
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3answers
255 views

Are there genes in humans from the common ancestor of all organisms?

How long ago can human genes be traced? Are there any genes that go back unchanged to the beginning of life on Earth? And if so, how many?
8
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1answer
223 views

How do the pharmacodynamics of the NSAIDs differ and are there “resistant” COX phenotypes?

I know that the non-steroidal anti-inflammatory drugs (e.g., aspirin, ibuprofen, naproxen) affect the enzymes cyclooxygenase (types I and II). Is there any difference in the degree to which these ...
3
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1answer
82 views

Predictable microchimerism

I read in New Scientist recently that microchimerism occurs between previously born siblings and grandparents, not just the mother. Do we know which parts of the genome are likely to be transferred? ...
4
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1answer
840 views

Is ovum + ovum fertilization possible for human?

In humans is it possible to fertilize a ovum with another ovum from the same female subject? I already found some works in which the ovum is fertilized by a somatic cell (see e.g. this ), but I am ...
7
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1answer
150 views

Is the function of adjacent genes correlated?

Do genes that occupy a similar locus on the genome have correlated function, specifically in human beings? It is my understanding that adjacent genes are inherited together, and so location plays a ...
4
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1answer
256 views

Can humans shorten their sleeping patterns?

Can sleeping patterns be trained, or are they genetic? I read that a human needs to sleep at least 4 hours. Can sleeping time be reduced without having a negative impact?
13
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2answers
220 views

What is the contribution of viruses to the evolution of mankind?

I'm interested in horizontal gene transfer in bacteria, viruses, and organisms such as Bdelloid Rotifers. I've just read in Carl Zimmer's 'A Planet of Viruses' the following passage: As a host ...
11
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3answers
315 views

Number of beneficial mutations cataloged?

I can see from Wikipedia that there are possibly thousands of harmful mutations that have been cataloged and linked to disease. There are also unnumbered neutral mutations. But, does anyone know how ...
9
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2answers
145 views

Is there any difference in terms of personal healthcare between complete DNA sequencing and SNPs genotyping?

There are several companies (most notably 23andMe) providing SNP genotyping for individuals claiming that there is no sense for individual in obtaining full genome sequence since only small part of it ...
6
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3answers
200 views

Genetic effects on personality

It is said that genes are partly responsible for the choices we make in our life; our genes help to create our environment, and then that environment can influence our personality. So, beside genes, ...
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1answer
89 views

Generating custom human DNA sequences based on traits such as eye colour?

I'm wondering if it would be possible to create software (unless some already exists, but I couldn't find any) to generate human DNA (the base pairs on the double helix) containing genes representing ...
12
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4answers
411 views

Questions to ask to a panel of people that will be sequenced

Some genes have been shown to be associated with left-handedness. Working with some clinicians, I've recommend them to ask their patients (whose genome will be sequenced) if they are "right or ...
6
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2answers
492 views

How are the gene sequences of individual sperm and egg cells “randomized”?

What I mean by "randomized" is, in the place where an egg cell or sperm cell is made, what is the mechanism by which each one is not made identically? Though I am a layman, I'm pretty sure that if the ...
10
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2answers
2k views

How is eye color in humans inherited?

In high school we studied the inheritance of eye color, as it was explained to us in the most simple way: blue eye color is a recessive, monogenic, autosomal trait. Now I know that it is a bit more ...