The scientific study of inheritance as it occurs specifically in human beings.

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Y Chromosome in Ovary Cancer Data

I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome ...
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124 views

Current Trend in Evolution of Human Intelligence

Up front, I am specifically not interested in philosophical or ethical considerations re Eugenics and related concepts. In an effort to receive a concise answer I'll post a narrowly defined question ...
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628 views

GWAS: why is replication in another cohort so crucial?

Almost all the landmark GWAS (Genome-Wide Association Studies) reviews agree that, for a GWAS finding to be valid, it needs to be replicated in an independent cohort. What exactly is the rationale ...
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38 views

Forensic genetics- why is mtDNA comparison sometimes better than nDNA comparison?

Why is (in forensic genetics) in some cases more appropriate comparison of nuclear DNA but in some other cases comparison of mitochondrial DNA? Is it because geneticists are sometimes unable to find ...
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3answers
80 views

DIY storing family DNAs' samples for future uses (eg medical)

I have a question I could not get an understandable reply from Google and I am no expert in the matter, so my plead to you is if you could give me practical and relatively easy to follow advice. With ...
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3answers
158 views

Swapping genes?

So, gene therapy is to take out a gene, correct its mutation, and put the corrected one back into the organism, right? Is it also possible to take out a gene from an organism and put in a totally ...
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1answer
61 views

Markers for human genetic mapping

For human genetic mapping several different types of markers are used: RFLPs (Restriction Fragment Length Polymorphisms) VNTRs (Variable Number of Tandem Repeats) such as mini- and microsatellites ...
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6answers
151 views

Which information can be obtained from a list of gene names?

Lets say I only have a list of gene names. I know they are up regulated and I know they are related to cancer. What information can I obtain from having only the names of genes? For example is there ...
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1answer
235 views

Understanding recombination scoring in family pedigrees

I am having some problems understanding recombination, and I am not sure what element I am missing here. This figure is an example from my text book. The pedigree belongs to a family with an autosomal ...
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94 views

Proving time travel

Consider this answer to an interesting question. It's not possible to prove completely that someone is the descendant of someone else, there's always a nonzero probability that the results are a ...
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1answer
64 views

How to determine genotype?

In humans, the ability or inability to roll the tongue is a single gene trait. The allele for tongue rolling (R) is dominant to the allele for not being able to roll the tongue (r). Whether ...
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1answer
35 views

MTHFR recessive alleles and B-vitamins

I know that being heterozygous or homozygous recessive for the MTHFR gene prevents that person from being able to process and use folate and B-12. It causes an unhealthy level of homocysteine to ...
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1answer
108 views

Why do haemophillic females $X^hX^h$ die before birth?

I just came across a statement in my book , while reading genetics, that haemophiliac females do not survive till birth (the reason not mentioned here why) . Before posting this question here I ...
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Plants and animals ability to survive polypoidy conditions [duplicate]

In mammals the condition polyploidy produce something euphemistically termed "general developmental disruption" ,practically speaking this means system meltdown which happens very quickly. There is ...
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1answer
25 views

What do we use as baseline to determine what genetic segments are “mutations” (and what are not)

In order to determine whether a particular segment of genetic code is a mutation, there must first be a baseline code on which that code looks somehow different. How has the baseline code been ...
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142 views

How far can we go in engineering our own evolution? [closed]

After recently seeing Christopher Nolan's Interstellar and reading Kip Thorne's The Science of Interstellar, I've seriously been reflecting on the challenges mankind faces in becoming space pioneers, ...
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25 views

How can I classify Breast Cancer if I have incomplete receptor information?

I have a clinical data table for a cohort of Breast Cancer patients and I want to classify them as being either triple negative or triple positive. You can find the file here. For some of the ...
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2answers
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Can genetically engineering the DNA of a human zygote, make it a twin of another human in entirety?

My question is simple. If I wanted to make an exact twin of an individual, will genetically engineering the DNA of the zygote to match with the individual suffice?
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1answer
279 views

How does a fetus retain a blood group different from its mother?

It's a well-established fact that blood group is decided by genotype. But, when a new child starts its journey in the womb, the mother's blood (along with it's agglutinins and agglutinogens) flows ...
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2k views

What is biological dark matter?

I recently stumbled upon the Biological Dark Matter wiki page. Its pretty light on details, but it appears to be genetic material found in humans that doesn't fall into currently classifications. ...
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334 views

Redheads and pain receptors

I remember reading this in a biology textbook, and decided to do a little digging. Redheads have a lower sensitivity to some pain and a higher sensitivity to other compared to people of other colored ...
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3answers
42 views

How do scientists decide which version of a polymorphism is the main one?

This in fact has bugged me for years, but now I finally remembered to ask. I suppose that if one variation is more frequent, it can be labeled as the default, but what about variations that are ...
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1answer
447 views

Why aren't green eyes more prevalent?

Why aren't green eyes more prevalent, given that the green allele is dominant over the blue one? My understanding is that human eye colour is determined by two genes: 1) HERC2, with alleles Bx, BB ...
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Question about clusters and populations [closed]

Whats the difference between a cluster and a population?...and do non africans cluster together? Examples European populations or the niger congo cluster.
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654 views

Father with mutated mtDNA- why isn't his offspring at risk?

Mothers transmit their mitochondria (and therefore mtDNA) to their offspring and fathers don't. Lets assume that father had a mutation of the gene that encodes mtDNA, would then be his offspring at ...
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2answers
2k views

What effect does the Barr body have, in relation to female Turner syndrome?

Why do persons with Turner syndrome have developmental abnormalities, when normal XX-females do not, even though they only have 1 active X chromosome? From what I know, one X-chromosome is ...
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1answer
227 views

A colony of humans are sent to an alien world, at what point would the descendants evolve to be genetically incompatible with Earth humans? [closed]

I recently heard about the evolution of the London Underground mosquitoes, and how they have changed genetically enough that they almost can no longer reproduce with above ground mosquitos. Since this ...
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406 views

Why do we have more male infant born?

For every 104 male babies,we have 100 female babies and there is a Statistics which is more reliable (we have 997 female infant born per 1000 male infant born). what's the reason? why do we have male ...
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Are the Chromosomes organized in any meaningful way? [closed]

So my major is in pharmacy but both my master and my (currently in progress) doctoral degree are both in theoretical chemistry. My thesis is about quantum chemistry and proteins, but it has a certain ...
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1k views

Why are irises unique?

I heard that irises are different and unique for every person. According this link, probability of two irises having identical pattern is 1 in 10 to the 78th power. That's how iris scanners identify ...
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1answer
1k views

Like other animals, why humans don't have species & breeds?

Like other animals, why don't humans have species & breeds ? Even my pet dog is one type of breed, but we (humans) lack breeds & species? What is the main reason?
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2k views

Why did humans lose their fur?

The little amount of body hair humans have don't seem to be of much use for keeping warm. Our Simian cousins on the other hand sport thick furs. At which point during the species evolution and why ...
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2answers
523 views

The gender of offspring of Twins?

Given identical twin males, Michael and Douglas, Douglas and his wife have four children, all of whom are girls. Michael and his wife have only one child, a boy, and are expecting another. What are ...
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3answers
1k views

What is the difference between eugenics and evolution by natural selection?

So with the working definition of Eugenics: "the aim to improve the human gene pool". What are key features that distinguish Eugenics from evolution by natural selection? I mean, besides that natural ...
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210 views

Can sealed epiphyseal growth plates theoretically be restored via epigenetic or genetic methods?

I know that epiphyseal growth plates seal up once people become young adults and that it is currently impossible to restore them to actively produce new bone growth but, is it theoretically possible ...
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Is it possible for a child to grow taller than their tallest parent?

I have heard that offspring can't grow taller than either of their parents but I've also heard that sometimes some gene activation can skip generations. Is it possible for a child to grow taller than ...
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1answer
46 views

Cell targets of Glybera

So we know that there is a first gene therapy drug in the market out there called Alipogene tiparvovec to address lipoprotein lipase deficiency (LPLD) at a genetic level. Does this genetic drug ...
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1answer
123 views

Possibility of Human cloning

Technology has evolved so much as to clone animals. But, what about human cloning? Is it really possible to create humans in lab? Or is it that technology has not advanced to that level..? Why cant ...
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3answers
506 views

Why has grey hair evolved?

A vast majority of humans get at least some grey hair as they age. As far as I know this applies to both genders and all races. Presumably this means that at least some grey haired humans have ...
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1answer
2k views

Why do humans seem so much more prone to disease than animals? [closed]

It seems like when we observe animals in the wild, the occurrence of noticeable disease in adult individuals is much lower than in humans. Why? There are a number of reasons that this could happen, ...
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3k views

Why doesn't the human skin grow back exactly how it was before being damaged?

Very simple: Why (and how) is regenerated skin different from original ? As we know we lose skin cells that becomes the dust in out homes and it always grows back to full thickness right ? So when I ...
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2answers
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Is there a realistic “family tree” model for the human population?

I would like to do some gene inheritance simulations, and I was wondering if there is an accepted model for what mating looks like in the general human population? I am not necessarily looking for the ...
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200 views

Is there some genetic variance underlying music appreciation?

Is there any research done on the genetic variance for Music appreciation? If not, why is there no genetic variance for this trait?
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181 views

Schedules of mating for men

It’s simple deductive logic to follow that for a species to survive it must provide it’s offspring with the best possible conditions to ensure it’s survival – either that or to reproduce in such ...
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1answer
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Will a vasectomy prevent genetic engineering of a child?

Making the assumption: Within 10 years, an adult will be able to genetically engineer (modify, enhance, clean, etc.) a child from their own DNA (and the DNA of a non-related partner). then would ...
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1answer
3k views

Why are men stronger than women?

What are the evolutionary explanations for why women are weaker than men (on average), and is this difference adaptive? See figure one here. I suppose that something puts pressure on men to be ...
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30 views

A question on exclusion of study participants for an Exome genotyping array

I'm reading a paper that used whole exome sequencing on an African American and European populations to discover novel low frequency and rare variants associated with lipid levels & the risk of ...
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1answer
40 views

Investigating rare variants in ethnically different populations (European ancestry & African ancestry)

If you are investigating low-frequency and rare variants for a complex trait using exome sequencing, why would one consider using different populations (African ancestry and European ancestry) ...
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62 views

Can a heterozygous allele show non-heterozygous expression in a family?

I'm doing a family study looking for novel cancer-associated variants in germ-line samples; the goal is to find candidate biomarkers which might be used for early detection. At an earlier step our ...
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1answer
379 views

Is there any measure by which the Germans today could be called a genetically superior race? [closed]

The Nazi eugenics programs are well known. Despite their controversy, I cannot find any indication on their effectiveness. Were there ever and studies done on the (arguably subjective definition of) ...