The scientific study of inheritance as it occurs specifically in human beings.

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96 views

Have there been any experiments that duplicate chromosome copies from 23*2 to 23*3 or 23*4?

Deinococcus radiodurans is an amazing bacterium with a fantastic survival rate. It can survive to high doses of radiation, in a complete vacuum and in hydrochloric acid. How does this bacterium ...
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0answers
80 views

Can DNA test of my grandparent's brother reveal my heritage from that branch of the family?

I'm thinking about doing that DNA test on all my grandparents to know where their genes come from. They are getting very old and I don't want to let the opportunity pass to gather more knowledge about ...
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60 views

Are the Chromosomes organized in any meaningful way? [closed]

So my major is in pharmacy but both my master and my (currently in progress) doctoral degree are both in theoretical chemistry. My thesis is about quantum chemistry and proteins, but it has a certain ...
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62 views

Can a heterozygous allele show non-heterozygous expression in a family?

I'm doing a family study looking for novel cancer-associated variants in germ-line samples; the goal is to find candidate biomarkers which might be used for early detection. At an earlier step our ...
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1answer
53 views

PGC-1β Sod2 limiters/blockers

I'd like to block a percentage of PGC-1β or Sod2 expression. According to the following paper's figure beta-blockers inhibit some expression of PGC-1α. Are there any medicines/chemicals which safely ...
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158 views

Swapping genes?

So, gene therapy is to take out a gene, correct its mutation, and put the corrected one back into the organism, right? Is it also possible to take out a gene from an organism and put in a totally ...
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130 views

Would it be correct to state that any biological difference between the sexes has to be found in the Y chromosome?

If the reason Why Men Don't Listen and Women Can't Read Maps is genetic, then one of the genes in the Y chromosome is to blame and in theory could be identified. Correct or incorrect?
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1answer
104 views

Generating custom human DNA sequences based on traits such as eye colour?

I'm wondering if it would be possible to create software (unless some already exists, but I couldn't find any) to generate human DNA (the base pairs on the double helix) containing genes representing ...
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3answers
42 views

How do scientists decide which version of a polymorphism is the main one?

This in fact has bugged me for years, but now I finally remembered to ask. I suppose that if one variation is more frequent, it can be labeled as the default, but what about variations that are ...
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141 views

Which was the last significant event in human evolution? What's next?

At 10.000 BC (12 ka), we became the last of the Homo species on Earth. In evolutionary terms this is a very little time range to something happen, but I'm wondering anyway, in this meantime which are ...
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53 views

Prader-Willi Syndrome and Angelman Syndrome?

On the website http://www.whatisepigenetics.com/fundamentals/2/ it states that the imprint disorders Prader-Willi syndrome and Angelman syndrome, display an abnormal phenotype as a result of the ...
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1answer
86 views

Is each generation getting older? [duplicate]

So we know that our sperm and egg cells get set aside relatively early so that they aren't going through unnecessary cell divisions and causing DNA damage or telomere shortening, but since each new ...
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1answer
46 views

Y-chromosome and phenotype

I have a male colleague which has a son that does not resemble its father in any degree (apart of being male). The "father" is thin, tan-skinned, brown-eyed and the "son" has blue eyes, blond and ...
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1answer
181 views

Schedules of mating for men

It’s simple deductive logic to follow that for a species to survive it must provide it’s offspring with the best possible conditions to ensure it’s survival – either that or to reproduce in such ...
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1answer
80 views

Are there any studies of epigenetic difference between twins during their lifespan?

Are there any studies of epigenetic difference between twins during their lifespan ? I ask because I wonder if there exist phases during lifespan, when environmental factors plays major role ...
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1answer
380 views

Is there any measure by which the Germans today could be called a genetically superior race? [closed]

The Nazi eugenics programs are well known. Despite their controversy, I cannot find any indication on their effectiveness. Were there ever and studies done on the (arguably subjective definition of) ...
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1answer
78 views

Religion and Genetics

Are there studies that investigate the heritability of believing in supernatural things (or related concepts)? Or stated differently. Are there studies that ...
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198 views

Hardy-Weinberg Equilibrium: To compute probability of finding two siblings (random mating)

I've been working a little with M. G. Bulmer's Principles of Statistics (Dover, 1979) and cannot see how to properly compute half of one question. This should be a basic probability computation, but I ...
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80 views

DIY storing family DNAs' samples for future uses (eg medical)

I have a question I could not get an understandable reply from Google and I am no expert in the matter, so my plead to you is if you could give me practical and relatively easy to follow advice. With ...
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1answer
25 views

What do we use as baseline to determine what genetic segments are “mutations” (and what are not)

In order to determine whether a particular segment of genetic code is a mutation, there must first be a baseline code on which that code looks somehow different. How has the baseline code been ...
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1answer
123 views

Possibility of Human cloning

Technology has evolved so much as to clone animals. But, what about human cloning? Is it really possible to create humans in lab? Or is it that technology has not advanced to that level..? Why cant ...
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1answer
30 views

A question on exclusion of study participants for an Exome genotyping array

I'm reading a paper that used whole exome sequencing on an African American and European populations to discover novel low frequency and rare variants associated with lipid levels & the risk of ...
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1answer
40 views

Investigating rare variants in ethnically different populations (European ancestry & African ancestry)

If you are investigating low-frequency and rare variants for a complex trait using exome sequencing, why would one consider using different populations (African ancestry and European ancestry) ...
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1answer
53 views

Alleles notation in SNPPedia criteria

I can understand the allele notation when is in the form rs8176719(T;T) or rs8176719(G) but recently i found this ones rs8176719(T;-) or rs8176719(-;T). So im confused, rs8176719(T;-) is the same as ...
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693 views

Amber eye color in Neolithic Africa

Given what we know of the genetics of eye color and their historical distribution, is it possible or at least plausible for a person born in the Horn of Africa during the early Neolithic (ca. 9000 ...
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2answers
72 views

Referencing the homologous chromosomes

There exist a co-ordinate system from chromosomes like "12p11.3". In this system, first integer range from 1 to 23 i.e it takes homologous chromosomes as a pair. If we want to distinguish among ...
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17 views

How should one interpret heritability? Is it related to $R^2$?

From Wiki: Heritability estimates are often misinterpreted if it is not understood that they refer to the proportion of variation between individuals on a trait that is due to genetic factors. It ...
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46 views

How to find name of the gene

Considering the kegg page, this page contains the description of the gene Edwardsiella tarda EIB202: ETAE_0074 . Now this gene has a name given in the page as : wabG. Now considering another gene 1 ...
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1answer
89 views

Have there been any “chopstick gene” mistakes in genetics? [closed]

I've heard of the "chopstick gene" fallacy - wrongly assuming an association between genetics and some characteristic, confounded by non-genetic factors. Has this fallacy happened in real life? I'm ...
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13 views

Serotonin activity with short 5-HTT promotor region and depression

So after reading a few studies (1,2) it seems that a shorter promotor region for the serotonin transport protein may be associated with increased likelihood of developing depression after stressful ...
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91 views

Why do my 23andme results only show me as 8.2% Scandinavian? [closed]

I just got my 23andme results back. My paternal grandfather was full Swedish. Shouldn't that make me 25% Swedish? 23andme tells me I'm only 8.2% Scandinavian. Or maybe my father inherited less than ...
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28 views

Will someone with a double mutation in the allosomes be normal?

Normally a female human has an X allosome from her father and an X allosome form her mother. What if an double mutation happened, which causes that someone has two X allosomes form her mother and no ...
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50 views

Would it be possible to create a gel, holding viruses, that could alter human genetic code when rubbed in?

I was wondering if it could be possible to engineer a virus, that when it comes into contact with human hair follicles, it could alter someones natural hair color. Naturally blue hair anyone? ...
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10 views

Plants and animals ability to survive polypoidy conditions [duplicate]

In mammals the condition polyploidy produce something euphemistically termed "general developmental disruption" ,practically speaking this means system meltdown which happens very quickly. There is ...
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20 views

Question about clusters and populations [closed]

Whats the difference between a cluster and a population?...and do non africans cluster together? Examples European populations or the niger congo cluster.
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210 views

Can sealed epiphyseal growth plates theoretically be restored via epigenetic or genetic methods?

I know that epiphyseal growth plates seal up once people become young adults and that it is currently impossible to restore them to actively produce new bone growth but, is it theoretically possible ...
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45 views

Plateletpheresis for hemophilia

Plateletpheresis is seperation of platelets from whole blood and putting the leukocytes and erythrocytes back into the blood. If the person donating platelets does not have hemophilia than could a ...
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0answers
34 views

Which disorders are fully concordant?

I work in neuroscience, mostly Alzheimer's disease (AD), with some work in autism spectrum disorder (ASD). The work is in gene regulation and epigenomics. I'm familiar with monozygotic twin (MZ) ...
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60 views

DNA fingerprinting

I would like to make my own DNA fingerprint - just for fun to have my "autoportrait":). I was looking around a bit and all the commercial kits you can have are very expensive. Can you suggest me a ...
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1answer
110 views

What percentage of people today would likely be descendants a man born 4,000 years ago?

Assuming a particular man was born in southern Mesopotamia, around 4,000 years ago, and was significant involved in a major religion. To what degree (if any) of accuracy could his descendants be ...
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1answer
137 views

Why are the genomes of Humans 99.5% the same?

Human's DNA sequence is said to be roughly 99.5% equal. As far as I understand, this means that if I walked up to you and compared our DNA, the sequence of base pairs would be 99.5% the same. My ...
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2answers
2k views

Genetically speaking, are dogs exactly similar to humans and chimps both?

Richard Dawkins mentions in his book The Greatest Show on Earth that dogs are exactly similar to both humans and chimps. Supposing that a cell contains the genetic similarity between 2 species, he ...
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2answers
108 views

how do I find the number of bp in chromosome 3 by knowing number of bp in chromosome 1?

If i have a number of bp in chromosome 1 for example(298,295,559 bp) can I use this number to find the number of bp in chromosome 3.
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3answers
138 views

Sense and anti sense strand

Why the sense strand is only involved in transcription though the antisense strand just has the compliment strand of the sense strand?
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23 views

“Heterozygotic expection” - when heterozygote differs from both homozygotes, but homozygotes are similar

For simple 2-alleles genetic model {a,A} and corresponding quantitative trait Q is typically true that Q(aa)>=Q(aA)>=Q(AA) or conversely Q(AA)>=Q(aA)>=Q(aA). For example, dominance means that ...
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2answers
709 views

What makes us all different and similar to some extent? [closed]

It is said that genes define how we look physically and psychologically; so for example if a male human sperm carries a certain number of genes, say x, and a female carries y, then mathematically ...
0
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1answer
121 views

What does it mean to have a Y-DNA Haplogroup “R-M512”? [closed]

I did a DNA test to learn about my origins, but the results are highly technical. I see I have a Y-DNA Haplogroup R-M512 and a mutation (zero marker in DYS448). I Googled these terms and came across ...
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2answers
54 views

When did human ancestors learn to walk? [closed]

Where does our ancestor learn to walk from? How do we control our legs whenever we take a step? I confuse every time whenever I take one step.
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88 views

difference in genetic instuctions between male and female [duplicate]

I'm a computer science graduate so please bear with me the following computer program : mov ecx, -1 INC ecx consist of 2 instructions (mov,inc) each working on specific data , can genetics ...
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1answer
151 views

why didn't natives of south america evolve darker skin?

I understand that darker skin tone is caused by melanin which helps to protect against the extra UV radiation that comes from more direct sunlight. It evolved in Africa before we migrated away from ...