The scientific study of inheritance as it occurs specifically in human beings.

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Is it possible to have raw ngs data to practice

I'm looking for raw human ngs data to practice in bioinformatics. Better if it is from different machines (illumina, roche, pacsbio, etc). Panels, exomes and genomes. Anyone knows something?
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59 views

Is it common to have multiple recessive traits in humans?

I just started thinking about my phenotype and realized I got multiple recessive traits. I have attached ear lobes, my blood type is O-, I got green eyes (I think eye color in polygenic but still ...
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128 views

What percentage of people today would likely be descendants a man born 4,000 years ago?

Assuming a particular man was born in southern Mesopotamia, around 4,000 years ago, and was significant involved in a major religion. To what degree (if any) of accuracy could his descendants be ...
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86 views

What causes the range of severity of neurological deficits in Down's syndrome?

It's known that the severity of symptoms caused by a trisomy 21 varies from individual to individual. Part of the explanation for this range of severity is the finding that 94% of Down's syndrome ...
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57 views

Y Chromosome in Ovary Cancer Data

I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome ...
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29 views

Runs of homozygosity - degree of inbreeding and disease associations

Been reading recently about methods to determine how inbred a particular person is by measuring their "runs of homozygosity." Loosly, these are defined as regions of the genome (typically >1Mb) where ...
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20 views

What would the resulting karyotype be if someone with Klinefelter syndrome fertilized an “empty” egg?

Endoreduplication: is a form of nuclear polyploidization that results in multiple, uniform copies of chromosomes. This process is common in plants and animals, especially in tissues with high ...
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136 views

Current Trend in Evolution of Human Intelligence

Up front, I am specifically not interested in philosophical or ethical considerations re Eugenics and related concepts. In an effort to receive a concise answer I'll post a narrowly defined question ...
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87 views

Can DNA test of my grandparent's brother reveal my heritage from that branch of the family?

I'm thinking about doing that DNA test on all my grandparents to know where their genes come from. They are getting very old and I don't want to let the opportunity pass to gather more knowledge about ...
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16 views

Robertsonian translocation on the same chromosome

is there any big difference between Robert-son-i-an translocation between two 13 chromosomes comparing to a translocation between 13 and 14 chromosomes
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53 views

How should one interpret heritability? Is it related to $R^2$?

From Wiki: Heritability estimates are often misinterpreted if it is not understood that they refer to the proportion of variation between individuals on a trait that is due to genetic factors. It ...
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55 views

How to find name of the gene

Considering the kegg page, this page contains the description of the gene Edwardsiella tarda EIB202: ETAE_0074 . Now this gene has a name given in the page as : wabG. Now considering another gene 1 ...
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Serotonin activity with short 5-HTT promotor region and depression

So after reading a few studies (1,2) it seems that a shorter promotor region for the serotonin transport protein may be associated with increased likelihood of developing depression after stressful ...
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31 views

Will someone with a double mutation in the allosomes be normal?

Normally a female human has an X allosome from her father and an X allosome form her mother. What if an double mutation happened, which causes that someone has two X allosomes form her mother and no ...
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52 views

Would it be possible to create a gel, holding viruses, that could alter the human genome when rubbed in?

I was wondering if it could be possible to engineer a virus, that when it comes into contact with human hair follicles, it could alter someones natural hair color. Naturally blue hair anyone? ...
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280 views

Can sealed epiphyseal growth plates theoretically be restored via epigenetic or genetic methods?

I know that epiphyseal growth plates seal up once people become young adults and that it is currently impossible to restore them to actively produce new bone growth but, is it theoretically possible ...
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70 views

Can a heterozygous allele show non-heterozygous expression in a family?

I'm doing a family study looking for novel cancer-associated variants in germ-line samples; the goal is to find candidate biomarkers which might be used for early detection. At an earlier step our ...
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47 views

Plateletpheresis for hemophilia

Plateletpheresis is seperation of platelets from whole blood and putting the leukocytes and erythrocytes back into the blood. If the person donating platelets does not have hemophilia than could a ...
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48 views

Which disorders are fully concordant?

I work in neuroscience, mostly Alzheimer's disease (AD), with some work in autism spectrum disorder (ASD). The work is in gene regulation and epigenomics. I'm familiar with monozygotic twin (MZ) ...
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62 views

DNA fingerprinting

I would like to make my own DNA fingerprint - just for fun to have my "autoportrait":). I was looking around a bit and all the commercial kits you can have are very expensive. Can you suggest me a ...
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12 views

Is it possible that one day people will all have the same eye color and skin color?

I was studying Mendelian Genetics and I get this doubt . Is it possible that one day people will all have the same eye color and skin color ?
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17 views

Genetic screening understanding requisites

I am a mathematics and philosophy undergraduate student studying a bit of a biology as part of a philosophy research project on genetic screening. I have not studied biology since I was 16 and I was ...
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21 views

Hybridization of an Indo-Aryan ethnic group and a Tibeto-Burmese ethnic group

The state in which I reside houses these two distinct ethnic groups. Physical Traits of the Indo-Aryan group Height:Medium Eyes:does not posses epicanthic fold Nasal bones:is not flat and broad ...
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20 views

Links between Genetics and Personality Types

This topic was visited briefly in the thread, Genetic Effects on Personality, but I was surprised not to find more on it. (Is there a taboo I don't know about? What's the ethical stance on this ...
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30 views

How to search for all human diseases associated with a inversion on chromosome 22?

Is there any way to search for all diseases that associated with inversions on chr22? I found some online research databases like OMIM and disgenet but I don't know the correct nomenclature on how to ...
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32 views

An elementary question for gene variation detection procedure in a paper

“Samples were divided into subtypes; each subtype was considered separately as a test set, using the remaining subtypes as the control. In our analysis, chromosome arms were subdivided into ...
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18 views

How to estimate the average improvement of the value of a phenotypic trait in an improved environment?

Let us assume there is a population and two environments x(good) and y(bad) on average those members of the population born and raised in the former environment show higher scores than the latter. ...
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13 views

heterolog bodysites development?

Would it actually be possible due to unhomogen distribution of growth factors in the growth of an embryo to develop conditions like Polydactyly only on one side of the body or in an even stranger ...
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32 views

Genetic component to the location of acquired nevi (moles) on humans?

One of my sons, currently age 4, who was (as is typical) born without moles, has begun to develop them (as is also typical). I noticed that his largest mole is in practically the exact same location ...