The scientific study of inheritance as it occurs specifically in human beings.

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5answers
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Do humans have enough biological differences to be grouped into races or subspecies?

After my online research on the subject, I learnt that, biologically speaking, many scientists believe that there is no such thing as a race. Homo sapiens as a species is only 200,000 years old, which ...
17
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2answers
13k views

How many people are required to maintain genetic diversity?

Imagine humans were to colonize a distant planet and it was a single one-way trip. How many people would they need to bring? Obviously 2 is the minimum, but that would result in a lot of inbreeding. ...
15
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2answers
319 views

What is the contribution of viruses to the evolution of mankind?

I'm interested in horizontal gene transfer in bacteria, viruses, and organisms such as Bdelloid Rotifers. I've just read in Carl Zimmer's 'A Planet of Viruses' the following passage: As a host ...
13
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2answers
2k views

The Uniqueness of DNA Paradox

How can everyone have unique iris and fingerprints? After a certain amount of human beings have lived on earth, wouldn't it be possible to exhaust all possible combinations? The same principle ...
13
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2answers
4k views

How is eye color in humans inherited?

In high school we studied the inheritance of eye color, as it was explained to us in the most simple way: blue eye color is a recessive, monogenic, autosomal trait. Now I know that it is a bit more ...
12
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4answers
473 views

Questions to ask to a panel of people that will be sequenced

Some genes have been shown to be associated with left-handedness. Working with some clinicians, I've recommend them to ask their patients (whose genome will be sequenced) if they are "right or left-...
11
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3answers
459 views

Number of beneficial mutations cataloged?

I can see from Wikipedia that there are possibly thousands of harmful mutations that have been cataloged and linked to disease. There are also unnumbered neutral mutations. But, does anyone know how ...
11
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1answer
1k views

Could humans and chimpanzees hybridize?

In some cases two species can hybridize. For example, Tigers and lions can hybridize to produce "Ligers". Would it also be possible for humans and chimpanzees (or any other species) to hybridize ? ...
11
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2answers
274 views

Is the function of adjacent genes correlated?

Do genes that occupy a similar locus on the genome have correlated function, specifically in human beings? It is my understanding that adjacent genes are inherited together, and so location plays a ...
10
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2answers
18k views

Why do we assume that the first humans were dark-skinned?

According to the article Dark skin and blue eyes: How Europeans once looked: It is widely accepted that Man's oldest common forefather was dark skinned, and that people became more pale as they ...
10
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2answers
3k views

Why did humans lose their fur?

The little amount of body hair humans have don't seem to be of much use for keeping warm. Our Simian cousins on the other hand sport thick furs. At which point during the species evolution and why ...
10
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1answer
13k views

Will a bone marrow transplant change one's blood type?

Will a bone marrow transplant change one's blood type? Or is the donor blood type matched with the person before transplant?
10
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1answer
187 views

Why do so many people have group O blood?

Please forgive me in case my question wouldn't make much sense. I was reading about ABO blood groups on Wikipedia, where I learnt that O is a recessive allele, and that it seems the A allele predates ...
9
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2answers
478 views

Why do we have more male infant born?

For every 104 male babies,we have 100 female babies and there is a Statistics which is more reliable (we have 997 female infant born per 1000 male infant born). what's the reason? why do we have male ...
9
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1answer
194 views

Is there any evidence that humans have faced extinction before?

Have we as a species faced extinction in the past? Resulting in a 'population bottleneck'? If so, what genetic evidence is there of this occurring?
9
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2answers
234 views

Cause of hexadactylisim in Amish people

Is it caused by inbreeding of many generations within an isolated population?
9
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1answer
734 views

Why are certain aneuploidies more common?

Certain aneuploidies such as trisomy-21 (Downs syndrome), trisomy-18 (Edward syndrome), Turner syndrome (XO) etc are more common than others. I had a vague thought that it is related to chromosome ...
9
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2answers
165 views

Is there any difference in terms of personal healthcare between complete DNA sequencing and SNPs genotyping?

There are several companies (most notably 23andMe) providing SNP genotyping for individuals claiming that there is no sense for individual in obtaining full genome sequence since only small part of it ...
9
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1answer
2k views

Did the eugenics program in Nazi Germany have a measurable effect? [closed]

Did the killing or sterilisation of people considered as living a "life unworthy of life" in Nazi Germany have any measurable effect on the "average health" of Germany? Is there any statistical ...
8
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1answer
566 views

Why aren't green eyes more prevalent?

Why aren't green eyes more prevalent, given that the green allele is dominant over the blue one? My understanding is that human eye colour is determined by two genes: 1) HERC2, with alleles Bx, BB ...
8
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3answers
343 views

What kind of event would cause the current Mitochondrial Eve to be replaced by a new one?

Apparently all living humans are matrilineal descendants of a single woman who lived 200.000 years ago. She is called Mitochondrial Eve. But at the time she lived there was a different matrilineal ...
8
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1answer
107 views

Horizontal gene transfer from humans

It is known that some viruses embed themselves in the human genome. Is there a mechanism by which human genes can be transferred to other animals or plants by means of viruses shuttling them from ...
8
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1answer
482 views

How do the pharmacodynamics of the NSAIDs differ and are there “resistant” COX phenotypes?

I know that the non-steroidal anti-inflammatory drugs (e.g., aspirin, ibuprofen, naproxen) affect the enzymes cyclooxygenase (types I and II). Is there any difference in the degree to which these ...
7
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2answers
739 views

Father with mutated mtDNA- why isn't his offspring at risk?

Mothers transmit their mitochondria (and therefore mtDNA) to their offspring and fathers don't. Lets assume that father had a mutation of the gene that encodes mtDNA, would then be his offspring at ...
7
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3answers
769 views

Why has grey hair evolved?

A vast majority of humans get at least some grey hair as they age. As far as I know this applies to both genders and all races. Presumably this means that at least some grey haired humans have ...
7
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3answers
217 views

Why are males more likely than females to have autism spectrum disorder?

The male to female ratio in autism spectrum disorder is around 4:1. However it seems ASD is not a simple X-linked disorder. Then how is it possible males are more susceptible than females, if the ...
7
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0answers
86 views

What causes the range of severity of neurological deficits in Down's syndrome?

It's known that the severity of symptoms caused by a trisomy 21 varies from individual to individual. Part of the explanation for this range of severity is the finding that 94% of Down's syndrome ...
6
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3answers
460 views

Are there genes in humans from the common ancestor of all organisms?

How long ago can human genes be traced? Are there any genes that go back unchanged to the beginning of life on Earth? And if so, how many?
6
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3answers
250 views

Genetic effects on personality

It is said that genes are partly responsible for the choices we make in our life; our genes help to create our environment, and then that environment can influence our personality. So, beside genes, ...
6
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2answers
734 views

How are the gene sequences of individual sperm and egg cells “randomized”?

What I mean by "randomized" is, in the place where an egg cell or sperm cell is made, what is the mechanism by which each one is not made identically? Though I am a layman, I'm pretty sure that if the ...
6
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2answers
1k views

GWAS: why is replication in another cohort so crucial?

Almost all the landmark GWAS (Genome-Wide Association Studies) reviews agree that, for a GWAS finding to be valid, it needs to be replicated in an independent cohort. What exactly is the rationale ...
6
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1answer
809 views

Why is there no cure for Dandruff?

It looks like a simple problem, affecting almost half of the population at the post-pubertal age and of any gender and ethnicity [wikipedia]. What is so complex about finding a cure? Also, if you know ...
5
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3answers
14k views

Is it possible for a child to grow taller than their tallest parent?

I have heard that offspring can't grow taller than either of their parents but I've also heard that sometimes some gene activation can skip generations. Is it possible for a child to grow taller than ...
5
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1answer
672 views

How does a fetus retain a blood group different from its mother?

It's a well-established fact that blood group is decided by genotype. But, when a new child starts its journey in the womb, the mother's blood (along with it's agglutinins and agglutinogens) flows ...
5
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1answer
2k views

Like other animals, why humans don't have species & breeds?

Like other animals, why don't humans have species & breeds ? Even my pet dog is one type of breed, but we (humans) lack breeds & species? What is the main reason?
5
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2answers
5k views

Why doesn't the human skin grow back exactly how it was before being damaged?

Very simple: Why (and how) is regenerated skin different from original ? As we know we lose skin cells that becomes the dust in out homes and it always grows back to full thickness right ? So when I ...
5
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2answers
166 views

How can a chromosome translocation in somatic cells lead to disease?

Looking at this picture... ...I get the impression that the part of chromosome is attached to other chromosome, but it is not mutated. When we assume that all genes in the translocated part are ...
5
votes
1answer
386 views

Understanding recombination scoring in family pedigrees

I am having some problems understanding recombination, and I am not sure what element I am missing here. This figure is an example from my text book. The pedigree belongs to a family with an autosomal ...
5
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1answer
4k views

Why are men stronger than women?

What are the evolutionary explanations for why women are physically weaker than men (on average), and is this difference adaptive? See figure one here. I suppose that something puts pressure on men ...
5
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1answer
56 views

Data on Gene Position in Human Genome

I am trying to get some data on gene position in the human genome and I need some help What I tried I downloaded ...
5
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1answer
129 views

Can we produce synthetic red blood cells lacking antigens?

I had an idea come to me during Biology class and I immediately asked my teacher, but she couldn't really answer the question, so I'll ask it here. What are the limiting factors in the production of ...
5
votes
1answer
359 views

What is a Mitochondrial Eve and Y-chromosomal Adam

I've read this question: What kind of event would cause the current Mitochondrial Eve to be replaced by a new one? And the values in Wikipedia about Mitochondrial Eve and Y-chromosomal Adam and I am ...
5
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1answer
457 views

Why do men grow facial hair?

Ancestral facial hair. Our closest ancestors, the chimpanzee and bonobo, both grow facial hair around the mouth area. What is noteworthy is that this is the case in both males and females of the ...
5
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1answer
122 views

How do I know which alleles the parents have?

I have the following assignment where I am to look at the "tree" (not sure the english word) and assign whether or not they can be autosomal dominant or recessive as well whether they can be X-linked ...
5
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1answer
3k views

Why do humans seem so much more prone to disease than animals? [closed]

It seems like when we observe animals in the wild, the occurrence of noticeable disease in adult individuals is much lower than in humans. Why? There are a number of reasons that this could happen, ...
5
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1answer
53 views

Implications of what the discovery of Naia means

Recently a discovery was made of a ~12,000 year old girl in Hoyo Negro in Mexico. This has been covered by many different news agencies. I'm confused however by many of the reports. Does it ...
5
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1answer
106 views

Where in the world does blue eyed whites originate from?

I know that there were no blue eyed people until ~6000 years ago due to a mutation and all blue eyed people have a single common anchestor. But where in the world does it originate? I assume it ...
4
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1answer
193 views

What is the evolutionary cause for various finger lengths?

Why are the lengths the way they are with middle finger the longest?
4
votes
2answers
701 views

The gender of offspring of Twins?

Given identical twin males, Michael and Douglas, Douglas and his wife have four children, all of whom are girls. Michael and his wife have only one child, a boy, and are expecting another. What are ...
4
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2answers
2k views

What is biological dark matter?

I recently stumbled upon the Biological Dark Matter wiki page. Its pretty light on details, but it appears to be genetic material found in humans that doesn't fall into currently classifications. ...