Immunoglobulins are also known as antibodies. They are Y-shaped proteins which are build up from four subunits and which bind to an antigen. Upon antigen binding they recruit the immune system for additional help (recognition of an antigen, endocytosis by macrophages etc.).

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Does class switching occur both in B cells and Plasma cells?

I understand that the cell class switches to change the type of immunoglobulin it is producing. The B-cell produces the membrane bound B-cell receptor (BCR) while the plasma cell produces the the ...
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What is the rationale behind IgM being the default antibody?

I know that the$\ C _\mu $ gene appears first in line for class switching and hence the IgM is the default antibody. But what is the rationale for it being so? There must be some advantage (...
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Why do we take antibiotics if our immune system already produces them? [closed]

Why do we take antibiotics if our immune system already produces them? Is it because our body doesnt make enough or the specific complementary antibody to fit with the antigen?
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IG isotypes in commercial mAb products

It appears that most monoclonal antibody medical products exclusively contain the IgG (and some IgE) isotypes. Also, some manufacturers use only certain IgG subclasses. While the IgG-isotype is the ...
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Is a variable domain in immunoglobulin's heavy chain different from the one in light chain?

I guess yes, there is difference in amino acid sequences of $V_L$ and $V_H$. And so we have 6 different complementarity determining regions (CDRs) per monomeric immunoglobulin as two heavy chains are ...
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55 views

What was Protein G named after?

Protein G (the bacterial antibody binding protein) is often used to pulldown antibodies, for example in chromatin immunoprecipitation (ChIP) experiments. However, I was unable to find a site ...
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Which process is right to describe V(D)J recombination? RAG-1 and RSS recurring process

I'm studying V(D)J recombination. I think I have two incompatible books about explantaion of the process. Which is right? In Molecular Biology of the Cell 5th Ed., firstly RAG (-1?) combines to RSSs ...
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IgA complement activation

Recently, I have been reading Janeway's immunobiology and had a question on immunoglobin A. I read that IgA activates the complement pathway using the Fab fragment of the IgA. How does IgA do that? I ...
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Can cancer be an immune system disorder? [closed]

Can cancer result from a weakened immune system? Would this mean that cancer could be considered an immune system disorder?
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What cell types produce immunoglobins and where are those cells found?

I know B cells found in bone marrow produce immunoglobin G. But IgM is produced in mucosal cells at least in the gut. Can you find immunoglobin expressing cells in other tissues in the human body? ...