Tagged Questions

The study of the immune system in organisms, primarily responsible for fighting infection.

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1answer
15 views

Action of Ebola Viruses

This video suggests that the first cell to be the victim of viral infection of ebola is the dendritic cell which acts as the leader of immune system cells.But I am unable to understand how the ...
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1answer
13 views

Why cytotoxic T cells don't kill dendritic cells when they present antigen?

When a cytotoxic T cell (CTL) recognizes a peptide presented in the MHC-1 of a dendritic cell (APC), why it doesn't kill this cell? I know that initially, in the lymph node, the T cell is ...
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0answers
14 views

Authoritative online dictionary of immunology terms?

Is there an authoritative and peer-reviewed online dictionary for immunology? I am referring specifically to the terms you find on papers, such as standard abbreviations for molecules, genes, mouse ...
3
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0answers
16 views

B cell receptor editing

If a B cell contains two mu chains and two lambda chains and is self reactive can it go back and rearrange its kappa light chains? I'm not sure if it can only try to rearrange its lambda light chains ...
2
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2answers
17 views

Food allergen-related skin reactions and intestinal inflammation?

Are there any connections between food allergen-related skin reactions causing intestinal (or more broadly, gastrointestinal) generalized inflammation? If such a link exists, is it related to any of ...
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2answers
40 views

Are all single-celled organisms Bacteria?

I read that "Bacteria are one-celled organisms that can multiply by division", are all one-celled organisms bacteria or are there any more narrow definitions?
2
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1answer
39 views

human immune system

The common cold and [some?] types of influenza are self-limiting. Some microorganisms cause self-limiting diarrhea. Is tuberculosis [potentially] self-limiting or not? To put it another way, suppose ...
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0answers
24 views

Fab : Molecular mechanism of fragment antigen binding

I would like to know about the molecular mechanism for FAB synthesis. I was able to refer some of the papers, but they discuss only the lab preparation of FAB. Where can I get the molecular procedure ...
5
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2answers
106 views

Synthesis of immunoglobulin Fab fragments: Where can I learn about Fab?

I wanted to know the chemical reaction involved in Fab synthesis. I looked everywhere for it. No luck. I know I will find it here. All I know for now is: Fab is a monovalent fragment that is ...
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2answers
40 views

Why do physicians try to match HLA complexes for organ transplant?

My understanding of acute transplant rejection is that donor dendritic cells present donor antigens on MHC1 to host naive CD8+ T-cells resulting in an immune response against the graft. If you match ...
4
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1answer
36 views

Is viral protein expression important for peptide vaccine?

I would like to know if proteins expressed in higher quantities, such as DNA polymerase, would be better vaccine candidates for a T-cell based vaccine. Thanks, Bernardo
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2answers
244 views

HIV and effectiveness of inhibitor cocktail over single inhibitor

I'm looking for clarification on the answer to this question. It's in my biochemistry class but I figured this is more Biology than Chemistry, so I'm asking it here. The question is: One of the ...
1
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1answer
42 views

Which immunosuppression caused by long-term usage of these antibiotics in untreated celiac disease?

These antibiotics include amoxicillin + acidum clavulanicum (beta-lactam, inhibit cell wall synthesis, broad specturm, 3rd gen aminopenicillin) / last part preventing the resistance ceftriaxone (3rd ...
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2answers
36 views

True or False: Vaccines are designed to protect against invaders that are encountered rarely, not all the time

I read the following statement in this article: Vaccines are designed to protect against invaders that are encountered rarely - not all the time Is it true? If yes, why?
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1answer
36 views

Is the innate immune system capable of identifying all foreign antigens?

I've been studying immunology on my own lately and I would like to know if the macrophages and the other components of the innate immune system are capable of identifying all foreign antigens. As far ...
0
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1answer
37 views

Epitope annotated protein

What is epitope annotted protein?? The book from which I got this term is : http://www.springer.com/biomed/immunology/book/978-1-4939-1114-1
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0answers
17 views

Sequence based method for prediction of continuous B cell epitope

What is Sequence based method for prediction of continuous B cell epitope? What is the algorithm/procedure of this method? Can someone please explain this to me in simple language?
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2answers
270 views

Why don't we develop immunity against common cold?

We all suffer from common cold, and that, frequently. Why have we not developed immunity against it till now? By immunity I mean immunity as a species.
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0answers
16 views

Immunomic Microarray

"One can measure two or more signals simultaneously determined by a single feature, i.e., epitope in immunomic microarray DNA microarrays measure one response value for each gene per sample; that ...
2
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2answers
64 views

peptide MHC microarray

"The recent technology is peptide–MHC microarray or artificial antigen-presenting chip. In this technique, recombinant peptide–MHC complexes and co-stimulatory molecules are immobilized on a ...
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0answers
26 views

recombinant peptide MHC complex

What is recombinant peptide-MHC complex??? Recombinant DNA means "to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in biological ...
2
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1answer
22 views

epitope prediction/ mapping

B-CELL EPITOPE PREDICTION Regarding this article: "Such a molecule can be synthesized or, in case of a protein, its gene can be cloned into an expression vector."----- is a particular line in ...
4
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1answer
41 views

Why can't the immune system start at the mating time?

The immune system has a great role in our body. When foreign particles enter our body, the immune system can recognize and start defense mechanisms such as the complement system and others. But when ...
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0answers
11 views

transfection of expression library made from cDNA into cells expressing the desired MHC haplotypes

http://www.sciencedirect.com/science/article/pii/S0167569997800205 If anybody has access to this paper, can you please explain me the process to find TAA based on transfection of expression library ...
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1answer
43 views

What is hTAP?? Please help

Could not find a single article regarding this. What is hTAP? Tap is Transfer associated protein, that I know, but what is hTAP??(I have not studied biology since last 8 years and now I am going ...
2
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1answer
45 views

Difference between sequential and conformational epitope

Is the difference only in its structure? Like conformational epitope has 3D structure while sequential has a linear structure?(I have not studied biology since last 8 years and now I am going through ...
4
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2answers
78 views

What is MHC haplotype?

What is MHC haplotype? I did check out the wiki article, but did not understand. (I have not studied biology since last 8 years and now I am going through it because I need it for my research. So if ...
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0answers
23 views

MHC restricted peptide

What is an MHC restricted peptide? "MHC-restricted antigen recognition, or MHC restriction, refers to the fact that a given T cell will recognize a peptide antigen only when it is bound to a host ...
4
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1answer
52 views

Oxidation means inflamation?

All right, I was reading article on nutrition, that focussed on content analysis of pastry-like food product for kids. I have to say that I am not sure this article would pass the imaginary smell ...
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34 views

Why is an inflammation in eye and brain more devastating and can lead to loss of organ function compared to other organ like liver etc.?

Recently I have learnt something about immunoprivileged site and I wonder why these sites like eye would prefer tolerating these antigens that sabotages the normal function of these to having ...
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0answers
21 views

Difference in structure of B-cell epitope and T-cell epitope

What is the difference in the structure of B-cell epitope and T cell epitope? Also please enlighten me with the fact of discontinuity or conformation of the b or t cell. Went through a number or ...
3
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1answer
36 views

SEREX serological analysis of cDNA expression library

What is Serological Analysis of cDNA expression library? I went through this article:http://cancerimmunity.org/serex/introduction/ but could not really make out. Can someone please explain this to me ...
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1answer
85 views

Complementarity Determining Regions (CDR)

Complementarity determining regions (CDRs) are part of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively, where these molecules ...
0
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1answer
22 views

Degenerate Alignment Analysis

Can someone please tell me what is Degenerate alignment analysis? Could not find a good article on the internet that could help me understand what it means? (I have not studied biology since last 8 ...
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0answers
22 views

TAA- Tumor associated antigen

An approach to find Tumor associated antigens is based on transfection of expression library made from cDNA into cells expressing desired MHC haplotypes. Can someone please explain what this line ...
1
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1answer
20 views

Microarray probe and target

In a microarray, which one is called a target and which one is the probe? the one that is added later , is that the probe or the one present in the slots of the microarray, that is the probe? (I have ...
2
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1answer
27 views

Immunodominant Peptide

Can someone please explain me the concept of Immunodominant peptide in simple language?? I did read the wiki article but did not understand it clearly. Please help! (I have not studied biology since ...
1
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1answer
37 views

Localization of B and T cell

What does localization of B-Cell mean?? "Localization of B and T cell in allergens may not coincide". What does this statement mean? (I have not studied biology since last 8 years and now I am going ...
2
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0answers
21 views

Subtypes of Acute myeloid leukemia

I am a computer scientist with no biological background and working on analyzing lab results of patients with Acute myeloid leukemia. They have been tagged with following subtypes of AML: AML with ...
2
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1answer
33 views

multiple HIV infection in same T cell

I was wondering can multiple HIV virus infecting same T cell ? Coz in flu virus they have SA to cleave of those sialic acid residue preventing re-infection of the same cell by other viruses to ...
3
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1answer
92 views

What is a protective epitope?

What is a protective epitope? An epitope is basically a part of antigen. So does it mean that when the epitope combines with an antibody, it helps in the functioning of the antibody instead of going ...
2
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0answers
35 views

What does the term 'epitope mapping' mean? [closed]

Epitope mapping means identifying the binding site of antibodies on the target antigen. This means that the site to be identified is part of the antigen and not antibody, am I right?
0
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1answer
37 views

What attracts cells to: pathogens, professional antigen-presenting cells, and cells with an antigen on its MHC-1 protein?

I have a few questions in regards to attraction/stimulation in the immune system. What attracts leukocytes and antibodies to pathogens in the first place? What attracts CD4+ cells to professional ...
2
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1answer
43 views

Calibration curve for single radial immunodiffusion

When we draw a calibration curve for single radial immunodiffusion, the curve does not pass through origin. Instead, there is a y intercept. Why does that happen ? Shouldn't zero antigen give zero ...
0
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1answer
58 views

can psychology of a person alter his immune system and health?

I just want to know that can psychology of a moderate aged person alter his immune health? because I have read many a times about the different types of linkages between nervous system and immune ...
3
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1answer
44 views

How specific is the adaptive immune response?

When you read about the adaptive immune response, you are often told that the response is specific to each pathogen - that the response is tailored. My question is - to what extent is this really ...
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0answers
58 views

Locally sterile immune response in paradoxical IRS coupled with hypersensitivity I

The king of sterile immune response is antibodies; while in unsterile response - T lymphocyte. I think there can be two types of IRS: either abnormalities with T or B cells. Assume the here the case ...
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0answers
18 views

What Are the Exit Routes of Vaccine Adjuvants?

The digestive and respiratory systems are set up to process externally introduced "stuff." Most vaccines are given via an intramuscular route. What happens to the virus and the adjuvant materials ...
0
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1answer
46 views

Tc and Th1 interaction and viral immune response

Tc is T cell which can give T killer cells and T helper cells. T helper cells (Th1) see the pathogen presented by antigen presenting cells (dendritic cells and macrophages). They then secrete antigens ...
6
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4answers
81 views

Exocytosis of mast cell secretory granules

I've been doing a bit of reading about mast cell degranulation and have become thoroughly lost while trying to understand how the secretory granules are actually secreted. I understand that there are ...