The study of the immune system in organisms, primarily responsible for fighting infection.

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How does mad cow disease evade immune system? [on hold]

The mad cow disease is caused by prions right? So how do prions avoid white blood cells and antibodies?
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What are the real chances of HIV transmission? [on hold]

I am really confused about this matter (as far as transmission via sexual intercourse is concerned). I've heard a lot of versions from doctors and on internet. To be more specific: A pathologist ...
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Problems with housekeeping genes

I have tried several housekeeping genes to analise the relative expresion of a cytokine for measure the inflamatory local response in mice ears, all the housekeeping genes I have tried are not stable (...
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Does class switching occur both in B cells and Plasma cells?

I understand that the cell class switches to change the type of immunoglobulin it is producing. The B-cell produces the membrane bound B-cell receptor (BCR) while the plasma cell produces the the ...
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Consequences of hypothetical MHCII mechanism

I am chemist doing research on certain toxic substances. In the course of our studies we came about certain possible properties of the investigated toxin. I would like to ask specialists about a ...
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Are HEK293 cells a positive control for wild type p53 expression?

I have searched in the web and found that these two antibodies from abcam use hek293 as positive control. * ab154036 * ab1101 But I am using another antibody: * AM11182PU-S (OriGene Technologies Inc.)...
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Effector protein emission rate in host by pathogen

Is emission of effector protein a one-time process in the host, or does it emit effector multiple times in the same host? If effector proteins are emitted multiple times by the pathogen into the host, ...
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Rate of production of proteins in gram negative pathogenic bacteria

What is the rate of production of effector proteins in the gram-negative pathogenic bacteria, if any? The translocation unit that is present during secretion of effectors in the secretion system that ...
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Zika Acquired Immunity

A woman is bitten by a mosquito carrying the Zika virus and then develops symptoms. Her symptoms disappear after a given amount of time and she becomes effectively immune to reinfection (assuming she ...
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Are apples really better for the immune system than most fruit? [migrated]

"An apple a day keeps the doctor away", the saying goes, implying that apples are somehow especially good for the immune system. But does this idiom have any validity to it? Are apples high in ...
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Do Tumor-Infiltrating T Cells Experience Any Prolonged Effects Due To Hypoxia After They Return To Normoxia?

Adoptive cell transfer (ACT) therapy using tumor-inflitrating lymphocytes (TIL) is at the cutting edge of immuno-oncology treatments involving metastatic melanoma and other indications (1). The idea ...
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Does denaturing proteins lead to loss of epitopes?

I am doing an experiment where I have to do both Immunohistochemistry and SDS-PAGE. I am assuming that the native conformation of the protein is maintained in the IHC. But during the blot, we heat the ...
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What is the rationale behind IgM being the default antibody?

I know that the$\ C _\mu $ gene appears first in line for class switching and hence the IgM is the default antibody. But what is the rationale for it being so? There must be some advantage (...
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Does RNA-LPX expression of antigen by DC induce only T-cell with that antigen specificity?

There was a recent publication concerning use of IV administered RNA-lipoplexes with an adjusted electrical charge to encourage dendritic cells (DC) to pick up the RNA package encoding viral or mutant ...
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How is histamine useful against allergies?

Histamine is a chemical produced and stored within the body. It is a part of our immune response and is released during an allergic reaction. Often histamine is responsible for hypersensitive ...
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Why do we take antibiotics if our immune system already produces them? [closed]

Why do we take antibiotics if our immune system already produces them? Is it because our body doesnt make enough or the specific complementary antibody to fit with the antigen?
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How is a T lymphocyte specific to an antigen but not specific to an epitope?

In my immunology notes, it states that B lymphocytes (and other APCs) capture and present antigens to T lymphocytes that is specific for an antigen, but that the T cells do not necessarily recognise ...
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How do we find antibiotics?

So the last class of antibiotics were made in 1984 (I think), which makes it appear as though they are hard to find(/design maybe). How is it then they were discovered? Was it by chance? I know some ...
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Have people in Africa already started evolving resistance to AIDS?

Are people living in areas where AIDS is rampant (for e.g. Africa), less likely to die from it than they once were because some of the people without genes/mutations that give them resistance already ...
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Is it possible to transfer acquired hemophilia with breast milk?

There is a transplacental form of acquired hemophilia: http://www.jpeds.com/article/S0022-3476%2895%2970132-X/abstract This disease is caused by polyclonal immunoglobulins (IgG1 and IgG4) against the ...
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How do T-cells determine which cells they've already inspected?

From what I understand, T-cells are constantly traveling in the body, inspecting cells by looking for antigens. If they're self antigens, then the T-cell doesn't attack, whereas if they're non-self, ...
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Why don't bacterial cell walls prevent bursting when attacked by the complement?

The complement system creates pores in cell membrane which leads to influx of lots of water thereby causing lysis of bacterial cell. But what I fail to understand is that if bacteria have cell walls ...
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Effect of HIV on T-cells

When HIV infects macrophages, it doesn't kill or destroy them immediately, but once it infects T-cells, they're destroyed. Why is that? As in why does it destroy T-cells and not macrophages or other ...
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Serological assays measuring antibody response

Given that an appropriate immune response to a bacteria may be thwarted in an individual, including not producing all of the antibodies which are known to occur in people who have been infected, or ...
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T cell sensitivity and persistence to specific bacterial proteins

Currently, the standard tests for Lyme Disease measure antibody production after exposure to a bacteria, Borrelia burgdorferi. Often, the tests are performed too soon after infection, before ...
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How does the body know to stop effector cell proliferation?

After a pathogen has been successfully neutralized, effector cells such as the plasma cells and the cytotoxic T cells which are specific for that pathogen decrease in numbers. What is the signal in ...
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B-cell antibody production

I've just learned about B cells in immunology lectures and some things are not clear to me. Here's what I know: 1) Apparently, each B cell produces a specific antibody, determined randomly at the ...
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Why I cannot find dendritic cells in blood smear?

According to many sources including wikipedia, there are haematopoietic stem cell derived dendritic cells in the blood. figure 1 - haematopoietic cell lines - ref Despite of this, when I examine ...
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How large are medullary thymic epithelial cells in volume?

I'm looking for a rough average volume of medullary thymic epithelial cells (mTECs/MECs) in humans and mice. It would also help to know how they differ in form (are they spherical, long stretched, ...
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IG isotypes in commercial mAb products

It appears that most monoclonal antibody medical products exclusively contain the IgG (and some IgE) isotypes. Also, some manufacturers use only certain IgG subclasses. While the IgG-isotype is the ...
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Does our immune system react on all bacteria?

In our body we carry a lot of bacteria. Some of them are bad for our health, but others are beneficial. For example bacteria may protect us against other pathogenic bacteria. But is our immune ...
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What is the difference between AIDS and SCID? [closed]

AIDS acquired immune deficiency syndrome According to wikipedia, Caused by infection with the human immunodeficiency virus (HIV).Following initial infection, a person may not notice any ...
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Why Alternative Dosing of Gardasil Puts Suspicion about its Efficacy?

I am studying the alternative dosing of Gardasil and its efficacy. The exact concentration necessary to confer protection is not yet known. This limits the understanding of the alternative dosing. ...
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Why is it advised that infants are fed mother's milk?

I have heard that mother's milk is preferred over other baby foods, because it contains immunoglobulines (secretory IgA), and other essential nutrients. But why is mother's milk so special? Any ...
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Can oral bacteria be targeted by white blood cells?

Today I was told from a dentist that a leukocyte is much larger than a bad bacterium. So a leukocyte cannot remove bad bacteria when they hide in very places like the space between the gums and teeth ...
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Does atrophy of the thymus not effect T-cell selection and tolerance?

The thymus atrophies as age progresses. Does the T cell selection (which happens in the thymus) continue to take place? This doubt came into my mind because in the cadaver we dissected, the thymus was ...
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How would the immune system respond to antigens and food poisoning?

QUESTION: How does this information explain the likelihood of a more violent response in someone who has already had food poisoning caused by salmonella bacteria WHAT I KNOW: In the first exposure, ...
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how to make plasma cells adhere to the bottom of a microplate?

I am isolating single plasma cells by FACS sorting into 384-well plates, with the intent to assay the supernatant and clone H/L chains from positive wells. The efficiency of the PCR is however low, ...
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What is the name of the property of viruses can activate a second time, with different symptoms?

The Varicella zoster virus causes chickenpox in children and shingles in adults. It appears after the initial infection, it can go dormant in the nerve, and reactivate itself decades later. In ...
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What is the name of the category of viruses that affect only one side of the body?

The Varicella zoster virus causes chickenpox in children and shingles in adults. When the virus attacks as shingles, one of its distinguishing characteristics is that it only affects one side of the ...
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How do CD 8+ Tc cells reach the site of tumors?

In normal humoral immunity, dendritic cells present antigens to the Th cells by arriving at the Lymph node. This is fine. But consider a tumor cell. How does the Tc cell sitting in the lymph node know ...
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What is the name of the property of viruses that can go dormant in the host for 30 years?

The Varicella zoster virus causes chickenpox in children and shingles in adults. It appears after the initial infection, it can go dormant in the nerve, and reactivate itself decades later. My ...
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Cytokine screening

I am measuring IL-6 production by NF-κB stimulation using IL-1α and TNFα. Il-1 produces a stronger degradation of IκBα (inhibitor of NF-κB). I've done this using ...
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Does sickle cell anaemia protect a victim against malaria? [duplicate]

My biology textbook says that a person with sickle cell anaemia is less prone to malaria. Why is that so? I'm guessing that its because the malarial parasite needs human RBCs for completing its life ...
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Why doesn't one develop immunity to bacterial STIs?

Why doesn't one develop immunity to STIs such as Chlamydia/Gonorrhea and Syphilis even after the first exposure and treatment with antibiotics?
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Why does immunity from the flu vaccine appear only after two weeks?

It is said that immunity from a flu vaccine appears after about two weeks. However, from experience, the flu usually lasts only a few days. If sufficient antibodies appear only after two weeks ...
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Do the antibodies in a patient suffering from Hashimoto's, attack the thyroid hormones or the thyroid gland (or both?)?

If oral thyroid hormone supplement is administered, is the attack stopped or does it just create an excess of thyroid hormones so that even after a lot of it is destroyed by the antibodies, there is ...
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How are vaccines and inoculations different? [closed]

If so are vaccinations more safe? If so how? And how is the vaccine a magical invention?
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Are there fundamental differences between the adaptive immune systems of higher primates and other mammals?

I recently attended a Leukemia and Lymphoma Society lecture in which one of the lecturers indicated that there are fundamental differences between the adaptive immune systems of higher primates and ...