The study of the immune system in organisms, primarily responsible for fighting infection.

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Subtypes of Acute myeloid leukemia

I am a computer scientist with no biological background and working on analyzing lab results of patients with Acute myeloid leukemia. They have been tagged with following subtypes of AML: AML with ...
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What does the term 'epitope mapping' mean? [closed]

Epitope mapping means identifying the binding site of antibodies on the target antigen. This means that the site to be identified is part of the antigen and not antibody, am I right?
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Autoimmunity and central tolerance

Where in the body are self antigens important? In terms of central tolerance and autoimmunity, but also in terms of T cell activation?
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Are there any antigen electronic sensors?

Is it possible somehow to attach antibody to silicon or to other electronic component chemical, and have electronic detector of correspondent antigen? Does such devices exist?
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A number of questions regarding chemotaxis assay using PBMCs

In our lab we would like to study the chemotaxis of PBMCs towards conditioned medium obtained following treatment of cancer cells with different compounds. My questions are regarding the method of ...
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55 views

Movement of stem cells from mother to fetus

Recent results from J Lee Nelson and colleagues (Sci Am. 2008 Feb;298(2):64-71; available as full text through Google) show that cells from the mother were found in a person aged 46. Logically, these ...
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How are T cells transported?

T cells are formed in bone marrow and mature in Thymus. How are they transported from bone marrow to thymus ? Through the lymph vessels ?
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What cell types produce immunoglobins and where are those cells found?

I know B cells found in bone marrow produce immunoglobin G. But IgM is produced in mucosal cells at least in the gut. Can you find immunoglobin expressing cells in other tissues in the human body? ...
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Conserved proteins are non immunogenic

I read that proteins that have been highly conserved are non-immunogenic. Why is it so ? What is the special thing that makes it non immunogenic(antibodies against them are hard to make) ?
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112 views

What causes peanut allergies?

Surveys show that 0.6 percent of the US population has an allergic reaction to peanuts. This prevalent allergy has even prompted some to ban peanuts from schools altogether. I am completely ...
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Is it possible to give a person an allergic reaction in a very specific place?

Can I give a person an allergic reaction at a very specific spot in a tissue? And if so, how accurate can i get?
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39 views

Why will tissue from identical twin be rejected in some cases?

From Medline Plus : Also, transplants from one identical twin to another are almost never rejected. My question : Why can a tissue from an identical twin be rejected ?
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46 views

Adaptability in immune system

I read somewhere that recently some people are trying to use harmless bacteria that live symbiotically in humans to express some portions of antigens of the harmful ones. Some people have raised ...
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54 views

Agglutination test using antibodies

Agglutination test Latex agglutination using bound antigens : by coating soluble (non - particulate ) antigens on to microscopic latex spheres, their reaction with a particular antibody can be ...
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273 views

Transfer of antibodies from mother to fetus

My questions: When does fetus begins to acquire antibodies from mother? Does it continue throughout the pregnancy? From Wikipedia: http://en.wikipedia.org/wiki/Passive_immunity This occurs around ...
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118 views

HIV and T helper cells

As far as I know and could understand from reading about HIV, T helper cell is one of the main reasons to develop AIDS in patients infected with HIV virus, that because the absence of helper T cell ...
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1answer
143 views

Are there any viruses or bacteria which have evolved to withstand higher temperatures due to fever

My question was raised after receiving this information: The primary reason the body raises its temperature (via the Hypothalamus in this case) is that bacteria and viruses tend to optimally ...
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1answer
82 views

What factors must be taken into account for the maintenance of the immunogenicity of ovalbumin antigen?

What factors must be taken into account for the maintenance of the immunogenicity of ovalbumin antigen? If the ovalbumin is aggregated, could we inject it for induction of immune reponse?
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351 views

Can the RNA in the HIV virus make viral enzymes without entering the nucleus?

If the provirus was not formed yet, can the virus make viral enzymes? (I know that it already has some, but supposing it doesn't)
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Is a naive immune system equally able to handle new antigens as an educated one?

This is a variation of the "does the immune system run out of memory" question. Here's a (possibly imperfect) thought experiment: You take two twins. One of them lives in a bubble from birth. One of ...
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45 views

Do's and Don't's of Undergraduate Research? [closed]

I was fortunate enough to get a position as a researcher for the Mayo Clinic's SURF Program this year. My PI's lab focus is on the the immune system's role in CNS axonal and neuronal injury, ...
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106 views

Why are haploid cancer cells not killed by immune system?

I have seen haploid cancer cells (I think it was leukemia cells) in a lab. Sperms and eggs are haploid but are not destroyed by the body because they are protected by other cells surrounding them. ...
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55 views

Can pets catch the cold?

Last night I was drying my cat with a towel after shenanigans in the rain and she sneezed! Questions Can cats/dogs/hamsters or other pets catch the cold? How quickly do they recover?
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86 views

How HIV Affects and Its Treatment using Combination Therapy

Can someone please help me with the following questions. I've written my specific questions right after the text question. Human immunodeficiency virus (HIV) is a retrovirus. Its genome is a single ...
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1answer
38 views

Variation in MHC in humans

What evolutionary process lead to so much variation in MHC? What is the advantage of having such variation?
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1answer
38 views

Can antimicrobial peptides be called antibiotics?

Antibiotic peptides are present in almost all multicellular eukaryotes. So can they be called antibiotics ? ( which are usually defined only for fungi and bacteria )
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Is an antivenom venomous?

What happens when someone takes an anti-venom for an animal they weren't bit by, either for incorrect identification of the animal they were bit by or if they weren't bit at all? I am looking for the ...
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Neutrophil elastase ELISA

I want to do the above assay but by mass spectrophotometry (MS). Hence I need to optimize in MS friendly buffers like formic acid, ammonium formate, ammonium acetate. Has any one done this ...
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What are the effects of excessive UV exposure on the human immune system?

In my readings, several authors have suggested that excessive/prolonged exposure to UV (particularly UVA) can have harmful long term effects on the human immune system. This leads to my question, ...
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517 views

More proteins from diet when common cold and flu?

My coach says that I need to eat 1.2 - 1.5 grams of proteins per kilogram when I have a common cold and flu. I normally eat one gram of proteins per kilogram, while double it when doing my exercise ...
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42 views

What is immunosuppression? Why would one use it? [closed]

What is immunosuppression? I know it is used in cancer patients, but why would one want to suppress the immune system? Do homeopathic physicians ever use immunosuppression, or do only allopathic ...
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1answer
54 views

can psychology of a person alter his immune system and health?

I just want to know that can psychology of a moderate aged person alter his immune health? because I have read many a times about the different types of linkages between nervous system and immune ...
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1answer
87 views

How does human body deal with inert solid material in the bloodstream?

How does human body deal with inert solid material in the bloodstream? For example, if there is a powder of glass injected into our bloodstream, will the white blood cells do anything or will kidney ...
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3answers
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Cell identification by Body Cells

How do the B-cells and T-cells recognize or distinguish a body cell from a foreign particle? I suspect something to do with this causes Auto Immune Disorders.
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What attracts cells to: pathogens, professional antigen-presenting cells, and cells with an antigen on its MHC-1 protein?

I have a few questions in regards to attraction/stimulation in the immune system. What attracts leukocytes and antibodies to pathogens in the first place? What attracts CD4+ cells to professional ...
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Tc and Th1 interaction and viral immune response

Tc is T cell which can give T killer cells and T helper cells. T helper cells (Th1) see the pathogen presented by antigen presenting cells (dendritic cells and macrophages). They then secrete antigens ...
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268 views

Do cockroaches have less health issues than humans?

Cockroaches are known to live in very dirty places like sewers. Does this cause them to evolve to be stronger against parasites and bacteria? Recently I read online that cockroaches can sustain ...
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Locally sterile immune response in paradoxical IRS coupled with hypersensitivity I

The king of sterile immune response is antibodies; while in unsterile response - T lymphocyte. I think there can be two types of IRS: either abnormalities with T or B cells. Assume the here the case ...
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What Are the Exit Routes of Vaccine Adjuvants?

The digestive and respiratory systems are set up to process externally introduced "stuff." Most vaccines are given via an intramuscular route. What happens to the virus and the adjuvant materials ...
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What are the purposes of granulocytes in acute inflammation?

I heard the phrase Neutrophilic leucocytes are kings in the acute inflammation. Neutrophils are granulocytes, while leucocytes are not granulocytes. I think this statement refers to the fact ...
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Why it is rare for person to get infected with two Pathogens?

Why is it rare for a person to have 2 (or more) infectious diseases (for example: Flu & Cold together at the same time)? Although it's rare, it happens when the immune system is weak (e.g when ...
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Why human body cannot defend against HIV? [closed]

Some says that HIV destroy IRF3, and some says HIV overruns T-cells.
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61 views

Can cancer be an immune system disorder? [closed]

Can cancer result from a weakened immune system? Would this mean that cancer could be considered an immune system disorder?