The study of the immune system in organisms, primarily responsible for fighting infection.

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How do the variable portions of antibody genes look in cells which don't produce antibodies?

There are several families of antibodies found in mammals. They may have two or more antibody domains which contain heavy and light chains. The variable regions of the light and heavy chains genes ...
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137 views

Antibody-antigen database

Is there a database where I can find an affinity estimate if I provide a given antibody and a given antigen sequence ? Input : antibody + antigen sequence Output : quantitative binding/affinity ...
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296 views

Can the immune system stop plasmodium from being active?

Suppose a female Anopheles infected with Plasmodium bites someone and transmits Plasmodium to their body. Can that person's immune system be strong enough that it can kill the Plasmodium before it ...
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During human ageing, which immune cell sub-types are most affected?

It is now well established that human ageing is accompanied by an increase in systemic, low-grade (chronic) inflammation, sometimes termed inflammaging (Franceschi, 2007). This is in part due to more ...
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42 views

A few questions regarding immunology [closed]

I know that there is a variable region on antibodies which can recognize a wide variety of antigens, and that germinal centers create more "fit" antibodies to respond to an infection. So I was just ...
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208 views

Who would win in a fight: an amoeba or a leukocyte?

(sorry, I couldn't resist the rhyming, silly title) I find it facinating that humans can suffer from an amoeba infestation. Amoeba must reproduce far more slowly than bacteria. In size, they seem to ...
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92 views

Is it possible to purify antigens from a vaccine and to separate them from the adjuvant?

I need to separate the antigens from several vaccines in order to use them for coating microplates to run an indirect ELISA. I at least need to remove the adjuvant from the vaccines. Is this possible ...
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How does drug-induced photosensitivity work?

Some drugs (tetracyclines, for instance) can cause photosensitivity reactions—that is, some patients become extremely sensitive to the sun, developing rashes or inflammation after spending time ...
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Immune reaction to “new” protein

I read in Bruce Alberts Molecular Biology of the cell : Normal mice,for example, cannot make an immune response against one of their own protein components of the complement system called C5. ...
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Why don't we form immunity to some infections?

I read another question, and its answers, about how vaccines work, but I don't see there, and and don't understand, why some infections can, seemingly, not be immunized against at all. For example, ...
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512 views

What is the beneficial function of IgE antibody?

Dont tell me the "function" of IgE is to cause allergy ! In whatever texts I have seen it is written that IgE is important to cause allergies but what is the beneficial function of IgE ? Why was it ...
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Loss of appetite during fever

It is a well-known phenomenon that sickness like the common flu is often accompanied by reduced appetite. Why do sick people stop eating?
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Presence of MHC on red blood cells

Do red blood cells have no MHC? (I have often heard that they do not.) If so why are they not destroyed by immune cells?
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Can the RNA in the HIV virus make viral enzymes without entering the nucleus?

If the provirus was not formed yet, can the virus make viral enzymes? (I know that it already has some, but supposing it doesn't)
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How does the immune system recognize pathogens?

There are useful and pathogenic bacteria in our body. How does the immune system differentiate between them?
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Why can blood group O be given to all blood groups?

Blood group O has antibodies against antigens A and B. Blood group A has A antigen. If someone with blood group A receives donor blood with group O, then anti-A antibodies in the donor blood should ...
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How do B memory cells provide immunological memory? Do they differentiate into plasma cells?

My text book doesn't say anything about how B memory cells actually ensure a faster response the second time the antigen is encountered. My guess is that they differentiate into plasma cells which ...
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Is the complement system a part of innate or adaptive immunity

I've been reading about the complement system, as part of the human immune system. The complement system is introduced as part of the article on innate immunity on Wikipedia. This classification makes ...
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388 views

variation in antigen binding site of antibodies

Antibodies or immunoglobulins are proteins made ​​by the immune system in response to alien(!) molecules. Each antibody binds to its specific antigen. This great diversity and specificity is cause of ...
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Persistent HPV and CVD in Women?

Cardiovascular disease is the number one morbidity factor of women. I am studying the relationship between persistent HPV infection and CVD (Cardiovascular Disease) in inadequate immune responses. ...
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63 views

human immune system

The common cold and [some?] types of influenza are self-limiting. Some microorganisms cause self-limiting diarrhea. Is tuberculosis [potentially] self-limiting or not? To put it another way, suppose ...
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Immunodominant Peptide

Can someone please explain me the concept of Immunodominant peptide in simple language?? I did read the wiki article but did not understand it clearly. Please help! (I have not studied biology since ...
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Manufacturing toxoids

Toxoids produced by tetanus and diphtheria bacteria are detoxified with formaldehyde, yet their antigen properties remain. Source : Biological Science by Taylor What does formaldehyde do ?
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What is the genetic basis of blood type (ABO) system?

What is the genetic basis of the A/B/B+/O/etc. blood type system? Are there definitive loci that correspond to each or can multiple different genotypes produce the same antigen profile? Also, is the ...
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343 views

How does the immune system distinguish own and foreign antibodies?

Therapeutic antibodies, for example Rituximab which recognises CD20 on B lymphoma cells, can cause adverse effects (e.g. http://www.ncbi.nlm.nih.gov/pubmed/19399690) One reason behind these adverse ...
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How to evaluate the efficacy of an antibody for fluorescence microscopy?

I'm trying to evaluate data taken from fluorescence microscopy with antibody staining, and am wondering whether there is any standard way to evaluate the specificity of the antibody for such ...
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What is the purpose of requiring two separate binding systems for the antibody response?

I've read that in most cases, B-cell activation requires helper T-cells. This requires antigen binding by both antibodies and T-cell receptors, using two different antigen-binding proteins, ...
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What happens to the excess immune cells or WBC in our body?

When we have an infection our immune system produces a large amount of white blood cells (WBCs) in our body to fight against the pathogen or parasite. My question is after the immune response has ...
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Can suppression of the immune system help cure chronic diseases?

I am not a biologist, but recently while reading an article on Scholarpedia about self-organization I encountered a fascinating biological observation concerning immune response to infections. To ...
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283 views

Why can we use mouse-produced antibodies on mice tissues?

I have seen biologists use mouse grown primary antibodies in mouse tissue, and they've told me that if the blood is perfused well then there is no problem with this method. How does the secondary ...
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563 views

Why are sperm cells not attacked by the female immune system? [duplicate]

Whenever a foreign particle enters into someone's body, it is attacked by the white blood cells. I just want how it is that, when sperms enter the female body, they are not attacked by the the woman's ...
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187 views

how do macrophages have the capacity to digest pathogen in opsonization

how do macrophages have the capacity to digest pathogen in opsonization but not in the first time when the pathogen is new and they play the role of antigen presenting cells(APCs) first ...
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72 views

B-cell and T-cell activation by parasites

Parasitic infections lead to the production of parasite-specific IgE, but they also lead to the activation of nonspecific, polyclonal B-cells and T-cells. How do parasites trigger non-specific ...
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SEREX serological analysis of cDNA expression library

What is Serological Analysis of cDNA expression library? I went through this article:http://cancerimmunity.org/serex/introduction/ but could not really make out. Can someone please explain this to me ...
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70 views

How specific is the adaptive immune response?

When you read about the adaptive immune response, you are often told that the response is specific to each pathogen - that the response is tailored. My question is - to what extent is this really ...
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Functioning of BCG vaccine

I read (from Nature Volume507, S4–S7 (06 March 2014) : For reasons that are poorly understood, BCG protects only infants; it is ineffective in older children and adults. Its efficacy also ...
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Number of MHCs in neurons

I have read that neurons have proportionately less MHC molecules than other cells of the body. What is the advantage of this?
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Can you cure allergies?

A common solution is allergy shots, which helps you adapt to the allergy. But are there ways to tell the body that this allergy is safe and there is no need to amount a response to it? So that there ...
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45 views

Natural Killer Cell and Cancer

NK cells are very effective in destroying circulating cancer cells before their extravasation into the organ, However they have only a minimal inhibiting effect on already established micrometastases. ...
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Why APC's present antigen to T cells?

the macrophages are pretty known well for antigen presenting process and to present the antigens which are bound to pathogens unlike exotoxins (which are free) the pathogen first should be digested ...
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Is MHC1 knockout sufficient to prevent transplant rejection?

A few days ago I read about MHC1 knockout pigs for organ transplantation research. I was just wondering, is it enough to knock out MHC1 in the donor (lets say from same species, pig to pig) for ...
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How to inhibit formation of specific antibodies (to antisera)?

Is there a way to inhibit an antibody response to a specific antigen using immunosupression? I am interested in reducing the anti-antibody formation to animal antibodies such as murine antibodies in ...
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Action of Ebola Viruses

This video suggests that the first cell to be the victim of viral infection of ebola is the dendritic cell which acts as the leader of immune system cells.But I am unable to understand how the ...
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414 views

Why cytotoxic T cells don't kill dendritic cells when they present antigen?

When a cytotoxic T cell (CTL) recognizes a peptide presented in the MHC-1 of a dendritic cell (APC), why it doesn't kill this cell? I know that initially, in the lymph node, the T cell is ...
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437 views

Dimerization of Immunoglobulin G

I would like to know the specific determinants for formation of IgG dimers. My understanding is the stem of the antibody is a homodimer of two heavy chains, covalently bonded through two disulfide ...
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How does your body ultimately recover from a cold?

Is it the eradication of the virus (assuming rhinovirus) by white blood cells? Or does your body somehow adapt to presence of the virus?
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Thymus and maternal microchimerism

I read in Bruce Alberts Molecular Biology of The Cell : ....If,however,cells from one strain of mouse are introduced into a neonatal mouse of another strain , some of these cells survive for most ...
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Why don't antibodies generally bind to food and drugs?

Are these excluded thru central tolerance? What if you ingested something with a unique molecular structure that you hadn't ingested before?
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Why are kidney discard rates so high?

A recent report from UNOS states: The kidney discard rate has returned to pre-KAS levels, dropping from 20.2 percent in the first six months to 18.4 percent in months 7-10. To me, this seems ...
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Human leukocytes (re)circulation/migration in homeostatic state

One can easily find information on the topic of leukocytes trafficking between vessels and peripheral tissues during inflammation. But what happens during normal states when there is no pathology? ...