The study of the immune system in organisms, primarily responsible for fighting infection.

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Are there any viruses or bacteria which have evolved to withstand higher temperatures due to fever

My question was raised after receiving this information: The primary reason the body raises its temperature (via the Hypothalamus in this case) is that bacteria and viruses tend to optimally ...
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627 views

If fever is a natural immune defense, why do people take drugs to lower it?

If fever is a natural defense against pathogens, why do sick people take NSAIDs to reduce the fever?
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111 views

Antibody-antigen database

Is there a database where I can find an affinity estimate if I provide a given antibody and a given antigen sequence ? Input : antibody + antigen sequence Output : quantitative binding/affinity ...
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114 views

Is there a strong reason to be sceptical about the “cured HIV patient” being reported by mainstream media?

There's a story going round the news about a baby that was, apparently, cured of HIV using a cocktail of drugs at an early age. The story piqued my interest, but details seem scarce. One of the main ...
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142 views

What factors must be taken into account for the maintenance of the immunogenicity of ovalbumin antigen?

What factors must be taken into account for the maintenance of the immunogenicity of ovalbumin antigen? If the ovalbumin is aggregated, could we inject it for induction of immune reponse?
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78 views

Is it possible to give a person an allergic reaction in a very specific place?

Can I give a person an allergic reaction at a very specific spot in a tissue? And if so, how accurate can i get?
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174 views

Can the immune system stop plasmodium from being active?

Suppose a female Anopheles infected with Plasmodium bites someone and transmits Plasmodium to their body. Can that person's immune system be strong enough that it can kill the Plasmodium before it ...
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Why don't we form immunity to some infections?

I read another question, and its answers, about how vaccines work, but I don't see there, and and don't understand, why some infections can, seemingly, not be immunized against at all. For example, ...
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What prevents a pregnant woman's immune system from recognizing her fetus as nonself (and attacking)?

I'm familiar with the scenario of Rh- mother with Rh+ fetus having complications (more so after her first child), but that's not what I'm curious about. I want to know mechanistically why a pregnant ...
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How to evaluate the efficacy of an antibody for fluorescence microscopy?

I'm trying to evaluate data taken from fluorescence microscopy with antibody staining, and am wondering whether there is any standard way to evaluate the specificity of the antibody for such ...
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277 views

variation in antigen binding site of antibodies

Antibodies or immunoglobulins are proteins made ​​by the immune system in response to alien(!) molecules. Each antibody binds to its specific antigen. This great diversity and specificity is cause of ...
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At what age do babies begin to synthesize their own antibodies?

When babies are first born, they receive their antibodies from their mother (I assume because they do not yet have the capacity to synthesize their own). So my question is, at what age do babies ...
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Why human body cannot defend against HIV? [closed]

Some says that HIV destroy IRF3, and some says HIV overruns T-cells.
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Why do people have antibodies against other blood types?

The ABO blood type divides each blood type according to whether they have the "A" and "B" antigen(s) (AB has both, O has none). People also have antibodies against the antigens they don't have (AB has ...
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Is it possible to purify antigens from a vaccine and to separate them from the adjuvant?

I need to separate the antigens from several vaccines in order to use them for coating microplates to run an indirect ELISA. I at least need to remove the adjuvant from the vaccines. Is this possible ...
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Do T-cells express MHC molecules?

T-cells recognize the MHC molecules and body's own peptides. When it doesn't, it alarms the immune system. But do T-cells express MHC molecules ? If so, how are they using it? If not, what happens ...
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259 views

Why does not the host produce any immune response to antiserum antibodies?

When an antiserum is injected to a person to protect oneself from a certain disease, the antibodies in the antiserum come from another organism. The question is: Why don't the injected antibodies ...
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220 views

How do infectious bacteria know when their numbers are high enough to attack a host?

When you get sick, you generally don't contract enough bacteria at once for them to succeed in battling your immune system, right? Their numbers must gradually increase in the host's body before they ...
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148 views

Conjugate secondary antibody

Why is the secondary antibody conjugated to the enzyme in ELISA, instead of the primary antibody? Wouldn't it be easier to conjugate the enzyme to the primary antibody?
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310 views

Insulin and monoclonal antibody production

When producing insulin, the gene for its production is inserted into the plasmid of a bacterium that is allowed to replicate freely. Why can't the same thing be done with antibodies (as I understand ...
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61 views

Is it more likely to develop a throat-ache at night?

I have noticed that I rarely develop phlemmy throat-aches in the daytime, but often notice them after I have been sleeping. Is this a recognised phenomenon? Could it be because viruses or bacteria ...
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89 views

Why glycoproteins are better than non-glycoproteins in fulfilling biological tasks?

I have just an intuition that the carbohydrate part of glycoproteins help them to fulfil those tasks like in plasma membranes. You can also get many more receptors if you can use carbohydrates too. ...
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426 views

Can the RNA in the HIV virus make viral enzymes without entering the nucleus?

If the provirus was not formed yet, can the virus make viral enzymes? (I know that it already has some, but supposing it doesn't)
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Multi-nucleated cells: advantages and examples?

This question arises because I saw that monocytes and leukocytes are commonly called 'mononuclear cells' in the scientific literature. The implication of course being that other immune sub-types are ...
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Why do vaccines cause your arm to hurt?

When you get a shot for a vaccine (for example, the annual flu vaccine), the nurse frequently indicates that your arm will ache for a day or two, maybe more. This ache is typically not just a pain ...
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How are antibodies designed?

Antibodies have the ability of recognising highly specific peptide sequences and bind it at their antigen-binding site. This ability is harnessed as a tool in research to purify target structures in ...
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322 views

Do antibiotics attenuate immune response on subsequent exposure to same bacteria?

A healthy immune response to a bacterial infection includes "memory" to permit the body to thwart subsequent exposure to same bacteria. What are the dynamics of using antibiotics on initial exposure ...
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During human ageing, which immune cell sub-types are most affected?

It is now well established that human ageing is accompanied by an increase in systemic, low-grade (chronic) inflammation, sometimes termed inflammaging (Franceschi, 2007). This is in part due to more ...
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What is the biological mechanism linking temperature and probability to be infected with a virus?

It is common knowledge that when you're cold you could get a cold. What is the mechanism linking temperature and viral infection?
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How and when did a dedicated immune system evolve?

I have recently been doing a lot of research into the interplay between the innate and adaptive immune systems in humans, and mammalian laboratory models. This has led to my reading some interesting ...
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338 views

Do cockroaches have less health issues than humans?

Cockroaches are known to live in very dirty places like sewers. Does this cause them to evolve to be stronger against parasites and bacteria? Recently I read online that cockroaches can sustain ...
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Do you know of any disease where HLA / MHC association discovery has led to better treatment or management?

If we discover an association between a disease and a particular HLA type (MHC class I or class II molecule) then it may provide us with some insight into the disease in a very basic way. However, ...
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Macrophage pathogen fixation

Overly simplified, macrophages recognise pathogenic patterns and endocytose anything that matches them. That also works on bacteria, which are quite often very mobile. What if a bacterium was just ...
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1k views

Is there a maximum amount of antibodies your body can keep?

I am wondering if you were theoretically able to get vaccinations or antibodies for any and every diseases and/or illness, would there be a limit to how many you can get and keep in your body at one ...
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242 views

In which order did the cells of the immune system evolve?

Thinking about how complex the interactions between different types of immune system cells (T-helpers, T-Killers, Phagocytes, B-Cells etc.) are, it's fascinating how they all combine to get the ...
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From inflammation to sickness and depression: when the immune system subjugates the brain

Recently, some research, for example this article has proposed that inflammation can cause innate immune cells to produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour. ...
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Using the IMGT/GENE-DB service to find RSS

I'm trying to get the data for the Human and Mouse 12 and 23 Recomination Signal Sequences (RSS), to run a classification algorithm on it. I'm not a biologist, so I apologise in advance for my ...
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151 views

Organ cloning - possible to make a non-antigenic organ?

From a J. Neil Schulman article on Organ Cloning: Cannibalizing organs from other people also entails the risk of rejection because of incompatibilities, not only for tissue-typing but also ...
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Why do people dying of immune deficiency diseases appear sick?

Please forgive the obviously silly appearance of this question, and/or of the tenor which may come across as flippant or dismissive of real world suffering. My intention is none of the above. As a ...
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234 views

How does herpes (HSV) infection suppress HIV?

HIV compromises the human body to defend against infection. Yet people who are infected with herpes are at less risk of developing AIDS. How does this work?
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What's the advantage of autocrine signalling?

In the antibody-mediated immune response, when the helper T cell gets activated by the costimulus (IL-2 and TNF-α secreted by the APC) which in turn produces IL-2, IL-2 acts in an autocrine manner. ...
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Harmless virus?

Is it possible for a virus to live symbiotically with its host? Is the human body plagued with viral infections that do negligible harm, or even serve a beneficial role?
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What cells would have the CD3 marker on them (other than T-cells)

Do you know of any peripheral blood mononuclear cells that would express any amount (beit low or high) of CD3 on their surface (other than T-cells)?
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Why do dendritic cells have CD4/CD8 on their surface?

Why do dendritic cells have CD4 or CD8 antigens on their surface? What is their function without the presence of a T-cell receptor?
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2k views

How does the immune system “learn” from a vaccine?

According to Wikipedia: A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe, its toxins or one ...
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241 views

Do antigens protrude through the capsule/slime layer in prokaryotic organisms where these features are present?

In prokaryotic organisms that have a slime layer or capsule, do intrinsic/extrinsic proteins and other molecules that could be used as antigens protrude through the capsule? I assume that they ...
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How is duration of efficacy estimated for vaccines?

Vaccines, especially those given in adulthood, usually have term limits attached, eg: 10 years for yellow fever or 3 years for typhoid. Since presumably the time course of an immune response is no ...
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Why is there an extended delay before G.M. liver cells are attacked by the immune system?

In this BBC article a trial is described where patients with B-Haemophillia are infected with modified Adeno-associated Virus 8 which contained the genes for Factor IX clotting protein. Trials seemed ...
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191 views

What are the clotting factors' effect on avascular necrosis development?

Do clotting factors tpa and pai-1 lead to degenerative osteoarthritis in the same way that lupus anticoagulant and prothrombin might? Is one of these pathways particularly detrimental during formation ...
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106 views

What are the main mechanisms of interaction between the nervous and immune systems?

We know from pop science that our psychological states have an effect on our immune systems ("worrying ourselves sick", etc.), but what are the actual mechanisms through which our nervous systems pass ...