The study of the immune system in organisms, primarily responsible for fighting infection.

learn more… | top users | synonyms

0
votes
1answer
35 views

Epitope annotated protein

What is epitope annotted protein?? The book from which I got this term is : http://www.springer.com/biomed/immunology/book/978-1-4939-1114-1
1
vote
2answers
37 views

Why do physicians try to match HLA complexes for organ transplant?

My understanding of acute transplant rejection is that donor dendritic cells present donor antigens on MHC1 to host naive CD8+ T-cells resulting in an immune response against the graft. If you match ...
4
votes
1answer
32 views

Is viral protein expression important for peptide vaccine?

I would like to know if proteins expressed in higher quantities, such as DNA polymerase, would be better vaccine candidates for a T-cell based vaccine. Thanks, Bernardo
6
votes
2answers
242 views

HIV and effectiveness of inhibitor cocktail over single inhibitor

I'm looking for clarification on the answer to this question. It's in my biochemistry class but I figured this is more Biology than Chemistry, so I'm asking it here. The question is: One of the ...
1
vote
1answer
39 views

Which immunosuppression caused by long-term usage of these antibiotics in untreated celiac disease?

These antibiotics include amoxicillin + acidum clavulanicum (beta-lactam, inhibit cell wall synthesis, broad specturm, 3rd gen aminopenicillin) / last part preventing the resistance ceftriaxone (3rd ...
2
votes
2answers
63 views

peptide MHC microarray

"The recent technology is peptide–MHC microarray or artificial antigen-presenting chip. In this technique, recombinant peptide–MHC complexes and co-stimulatory molecules are immobilized on a ...
5
votes
3answers
57 views

Do you know of any disease where HLA / MHC association discovery has led to better treatment or management?

If we discover an association between a disease and a particular HLA type (MHC class I or class II molecule) then it may provide us with some insight into the disease in a very basic way. However, ...
1
vote
2answers
31 views

True or False: Vaccines are designed to protect against invaders that are encountered rarely, not all the time

I read the following statement in this article: Vaccines are designed to protect against invaders that are encountered rarely - not all the time Is it true? If yes, why?
0
votes
1answer
34 views

Is the innate immune system capable of identifying all foreign antigens?

I've been studying immunology on my own lately and I would like to know if the macrophages and the other components of the innate immune system are capable of identifying all foreign antigens. As far ...
10
votes
2answers
193 views

Why don't we develop immunity against common cold?

We all suffer from common cold, and that, frequently. Why have we not developed immunity against it till now? By immunity I mean immunity as a species.
0
votes
0answers
16 views

Sequence based method for prediction of continuous B cell epitope

What is Sequence based method for prediction of continuous B cell epitope? What is the algorithm/procedure of this method? Can someone please explain this to me in simple language?
1
vote
0answers
24 views

recombinant peptide MHC complex

What is recombinant peptide-MHC complex??? Recombinant DNA means "to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in biological ...
0
votes
0answers
16 views

Immunomic Microarray

"One can measure two or more signals simultaneously determined by a single feature, i.e., epitope in immunomic microarray DNA microarrays measure one response value for each gene per sample; that ...
-2
votes
1answer
43 views

What is hTAP?? Please help

Could not find a single article regarding this. What is hTAP? Tap is Transfer associated protein, that I know, but what is hTAP??(I have not studied biology since last 8 years and now I am going ...
4
votes
1answer
41 views

Why can't the immune system start at the mating time?

The immune system has a great role in our body. When foreign particles enter our body, the immune system can recognize and start defense mechanisms such as the complement system and others. But when ...
2
votes
1answer
21 views

epitope prediction/ mapping

B-CELL EPITOPE PREDICTION Regarding this article: "Such a molecule can be synthesized or, in case of a protein, its gene can be cloned into an expression vector."----- is a particular line in ...
4
votes
2answers
74 views

What is MHC haplotype?

What is MHC haplotype? I did check out the wiki article, but did not understand. (I have not studied biology since last 8 years and now I am going through it because I need it for my research. So if ...
1
vote
0answers
10 views

transfection of expression library made from cDNA into cells expressing the desired MHC haplotypes

http://www.sciencedirect.com/science/article/pii/S0167569997800205 If anybody has access to this paper, can you please explain me the process to find TAA based on transfection of expression library ...
2
votes
1answer
28 views

Difference between sequential and conformational epitope

Is the difference only in its structure? Like conformational epitope has 3D structure while sequential has a linear structure?(I have not studied biology since last 8 years and now I am going through ...
0
votes
0answers
23 views

MHC restricted peptide

What is an MHC restricted peptide? "MHC-restricted antigen recognition, or MHC restriction, refers to the fact that a given T cell will recognize a peptide antigen only when it is bound to a host ...
4
votes
1answer
51 views

Oxidation means inflamation?

All right, I was reading article on nutrition, that focussed on content analysis of pastry-like food product for kids. I have to say that I am not sure this article would pass the imaginary smell ...
1
vote
0answers
32 views

Why is an inflammation in eye and brain more devastating and can lead to loss of organ function compared to other organ like liver etc.?

Recently I have learnt something about immunoprivileged site and I wonder why these sites like eye would prefer tolerating these antigens that sabotages the normal function of these to having ...
3
votes
1answer
33 views

SEREX serological analysis of cDNA expression library

What is Serological Analysis of cDNA expression library? I went through this article:http://cancerimmunity.org/serex/introduction/ but could not really make out. Can someone please explain this to me ...
0
votes
0answers
20 views

Difference in structure of B-cell epitope and T-cell epitope

What is the difference in the structure of B-cell epitope and T cell epitope? Also please enlighten me with the fact of discontinuity or conformation of the b or t cell. Went through a number or ...
1
vote
1answer
50 views

Complementarity Determining Regions (CDR)

Complementarity determining regions (CDRs) are part of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively, where these molecules ...
0
votes
1answer
22 views

Degenerate Alignment Analysis

Can someone please tell me what is Degenerate alignment analysis? Could not find a good article on the internet that could help me understand what it means? (I have not studied biology since last 8 ...
1
vote
1answer
20 views

Microarray probe and target

In a microarray, which one is called a target and which one is the probe? the one that is added later , is that the probe or the one present in the slots of the microarray, that is the probe? (I have ...
0
votes
0answers
22 views

TAA- Tumor associated antigen

An approach to find Tumor associated antigens is based on transfection of expression library made from cDNA into cells expressing desired MHC haplotypes. Can someone please explain what this line ...
2
votes
1answer
25 views

Immunodominant Peptide

Can someone please explain me the concept of Immunodominant peptide in simple language?? I did read the wiki article but did not understand it clearly. Please help! (I have not studied biology since ...
1
vote
1answer
37 views

Localization of B and T cell

What does localization of B-Cell mean?? "Localization of B and T cell in allergens may not coincide". What does this statement mean? (I have not studied biology since last 8 years and now I am going ...
2
votes
1answer
31 views

multiple HIV infection in same T cell

I was wondering can multiple HIV virus infecting same T cell ? Coz in flu virus they have SA to cleave of those sialic acid residue preventing re-infection of the same cell by other viruses to ...
2
votes
0answers
21 views

Subtypes of Acute myeloid leukemia

I am a computer scientist with no biological background and working on analyzing lab results of patients with Acute myeloid leukemia. They have been tagged with following subtypes of AML: AML with ...
3
votes
1answer
77 views

What is a protective epitope?

What is a protective epitope? An epitope is basically a part of antigen. So does it mean that when the epitope combines with an antibody, it helps in the functioning of the antibody instead of going ...
2
votes
0answers
35 views

What does the term 'epitope mapping' mean? [closed]

Epitope mapping means identifying the binding site of antibodies on the target antigen. This means that the site to be identified is part of the antigen and not antibody, am I right?
5
votes
2answers
107 views

Is there a strong reason to be sceptical about the “cured HIV patient” being reported by mainstream media?

There's a story going round the news about a baby that was, apparently, cured of HIV using a cocktail of drugs at an early age. The story piqued my interest, but details seem scarce. One of the main ...
9
votes
2answers
12k views

Why do vaccines cause your arm to hurt?

When you get a shot for a vaccine (for example, the annual flu vaccine), the nurse frequently indicates that your arm will ache for a day or two, maybe more. This ache is typically not just a pain ...
0
votes
1answer
57 views

can psychology of a person alter his immune system and health?

I just want to know that can psychology of a moderate aged person alter his immune health? because I have read many a times about the different types of linkages between nervous system and immune ...
1
vote
1answer
88 views

How HIV Affects and Its Treatment using Combination Therapy

Can someone please help me with the following questions. I've written my specific questions right after the text question. Human immunodeficiency virus (HIV) is a retrovirus. Its genome is a single ...
0
votes
1answer
33 views

What attracts cells to: pathogens, professional antigen-presenting cells, and cells with an antigen on its MHC-1 protein?

I have a few questions in regards to attraction/stimulation in the immune system. What attracts leukocytes and antibodies to pathogens in the first place? What attracts CD4+ cells to professional ...
2
votes
1answer
38 views

Calibration curve for single radial immunodiffusion

When we draw a calibration curve for single radial immunodiffusion, the curve does not pass through origin. Instead, there is a y intercept. Why does that happen ? Shouldn't zero antigen give zero ...
4
votes
2answers
180 views

What's the difference between naive and memory B cells?

I understand that when naive B cells are exposed to antigens, they become memory B cells, but what is the functional difference between the two? I've looked at the quite a few article on B cells, but ...
3
votes
1answer
43 views

How specific is the adaptive immune response?

When you read about the adaptive immune response, you are often told that the response is specific to each pathogen - that the response is tailored. My question is - to what extent is this really ...
0
votes
0answers
47 views

Locally sterile immune response in paradoxical IRS coupled with hypersensitivity I

The king of sterile immune response is antibodies; while in unsterile response - T lymphocyte. I think there can be two types of IRS: either abnormalities with T or B cells. Assume the here the case ...
2
votes
0answers
41 views

Autoimmunity and central tolerance

Where in the body are self antigens important? In terms of central tolerance and autoimmunity, but also in terms of T cell activation?
2
votes
1answer
41 views

Allergic rhinitis vaccine

Note : Any answer to this question will not be (and should not be) taken as medical advice. One of my friends has allergic rhinitis and has been prescribed an oral vaccine. He is allergic to 3 ...
6
votes
4answers
80 views

Exocytosis of mast cell secretory granules

I've been doing a bit of reading about mast cell degranulation and have become thoroughly lost while trying to understand how the secretory granules are actually secreted. I understand that there are ...
1
vote
3answers
125 views

HIV and T helper cells

As far as I know and could understand from reading about HIV, T helper cell is one of the main reasons to develop AIDS in patients infected with HIV virus, that because the absence of helper T cell ...
-2
votes
2answers
76 views

Why it is rare for person to get infected with two Pathogens?

Why is it rare for a person to have 2 (or more) infectious diseases (for example: Flu & Cold together at the same time)? Although it's rare, it happens when the immune system is weak (e.g when ...
0
votes
0answers
18 views

What Are the Exit Routes of Vaccine Adjuvants?

The digestive and respiratory systems are set up to process externally introduced "stuff." Most vaccines are given via an intramuscular route. What happens to the virus and the adjuvant materials ...
0
votes
1answer
46 views

Tc and Th1 interaction and viral immune response

Tc is T cell which can give T killer cells and T helper cells. T helper cells (Th1) see the pathogen presented by antigen presenting cells (dendritic cells and macrophages). They then secrete antigens ...