The study of the immune system in organisms, primarily responsible for fighting infection.

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Binding of Multivalent Antibody to mutiple epitopes?

A multivalent antibody molecule such as Immunoglobulin M Immunoglobulin A etc bind to more than one antigens or epitopes but I am confused about that wheather these multivalent antibodies bind to ...
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B cell receptor editing

If a B cell contains two mu chains and two lambda chains and is self reactive can it go back and rearrange its kappa light chains? I'm not sure if it can only try to rearrange its lambda light chains ...
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Deactivation of plasma cells [closed]

Is it possible to deactivate plasma cells or B-cells? So far I haven't found many answers on the Internet or in Stack Exchange. Please help! Also, please include references. So my ideas were to use ...
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The ethics of ACST in full blown AIDS patients [closed]

We've always been told that a traditional Allogeneic Stem Cell Transplant (bone marrow transplant) is unsuitable as a treatment option for those living with HIV due to the mortality risks it carries ...
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Do T-cells express MHC molecules?

T-cells recognize the MHC molecules and body's own peptides. When it doesn't, it alarms the immune system. But do T-cells express MHC molecules ? If so, how are they using it? If not, what happens ...
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How can site-directed mutagenesis be used to suppress the production of anti-antibodies?

In a previous post of mine, I asked how to supress the creation of anti-antibodies in vivo. In the answer, it was mentioned that site-directed mutagenesis could be used. Currently, I can't find mcuh ...
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Anti-antibodies for preventing transplant rejection

Transplanted organs from the donor are attacked by antibodies from the recepient. So can't we construct anti-antibodies and destroy specifically those antibodies which are causing the rejections ? ...
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How to inhibit formation of specific antibodies (to antisera)?

Is there a way to inhibit an antibody response to a specific antigen using immunosupression? I am interested in reducing the anti-antibody formation to animal antibodies such as murine antibodies in ...
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Ebola immunosupression and infection

I was wondering... If Ebola attacks immune cells and causes immunosupression, then shouldn't we see death in Ebola patients due to secondary infection?
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A few questions regarding immunology [closed]

I know that there is a variable region on antibodies which can recognize a wide variety of antigens, and that germinal centers create more "fit" antibodies to respond to an infection. So I was just ...
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Presence of MHC on red blood cells

Do red blood cells have no MHC? (I have often heard that they do not.) If so why are they not destroyed by immune cells?
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Autoimmunity and central tolerance

Where in the body are self antigens important? In terms of central tolerance and autoimmunity, but also in terms of T cell activation?
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allogeneic organ transplant and the immune response

What happens when an allogeneic organ transplant is performed on an immunocompetent recipient vs. when it is performed on an immunosuppresed recipient using a donated organ with immunocompetent cells? ...
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Why do physicians try to match HLA complexes for organ transplant?

My understanding of acute transplant rejection is that donor dendritic cells present donor antigens on MHC1 to host naive CD8+ T-cells resulting in an immune response against the graft. If you match ...
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human anti-mouse antibody

I have heard about human anti-mouse antibodies (HAMAs) and read that HAMAs neutralize murine antibodies, therefore decreasing the effectiveness of those murine antibodies. Is this true that HAMAs ...
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B-cell and T-cell activation by parasites

Parasitic infections lead to the production of parasite-specific IgE, but they also lead to the activation of nonspecific, polyclonal B-cells and T-cells. How do parasites trigger non-specific ...
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29 views

MHC-I presentation during infection

Which cell type cannot process and present antigen peptide in association with MHC-I when it is infected?
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Why cytotoxic T cells don't kill dendritic cells when they present antigen?

When a cytotoxic T cell (CTL) recognizes a peptide presented in the MHC-1 of a dendritic cell (APC), why it doesn't kill this cell? I know that initially, in the lymph node, the T cell is ...
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Action of Ebola Viruses

This video suggests that the first cell to be the victim of viral infection of ebola is the dendritic cell which acts as the leader of immune system cells.But I am unable to understand how the ...
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Using the IMGT/GENE-DB service to find RSS

I'm trying to get the data for the Human and Mouse 12 and 23 Recomination Signal Sequences (RSS), to run a classification algorithm on it. I'm not a biologist, so I apologise in advance for my ...
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human immune system

The common cold and [some?] types of influenza are self-limiting. Some microorganisms cause self-limiting diarrhea. Is tuberculosis [potentially] self-limiting or not? To put it another way, suppose ...
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Food allergen-related skin reactions and intestinal inflammation?

Are there any connections between food allergen-related skin reactions causing intestinal (or more broadly, gastrointestinal) generalized inflammation? If such a link exists, is it related to any of ...
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Are all single-celled organisms Bacteria?

I read that "Bacteria are one-celled organisms that can multiply by division", are all one-celled organisms bacteria or are there any more narrow definitions?
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109 views

Synthesis of immunoglobulin Fab fragments: Where can I learn about Fab?

I wanted to know the chemical reaction involved in Fab synthesis. I looked everywhere for it. No luck. I know I will find it here. All I know for now is: Fab is a monovalent fragment that is ...
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Reasons why people say that AIDS/HIV doesn't exist

It's been recurrent when I hear people saying that AIDS doesn't exist. When I ask why, they give weird reasons like HIV is a virus created to control economy and to develop medicine, etc. Also when I ...
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Epitope annotated protein

What is epitope annotted protein?? The book from which I got this term is : http://www.springer.com/biomed/immunology/book/978-1-4939-1114-1
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Is viral protein expression important for peptide vaccine?

I would like to know if proteins expressed in higher quantities, such as DNA polymerase, would be better vaccine candidates for a T-cell based vaccine. Thanks, Bernardo
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HIV and effectiveness of inhibitor cocktail over single inhibitor

I'm looking for clarification on the answer to this question. It's in my biochemistry class but I figured this is more Biology than Chemistry, so I'm asking it here. The question is: One of the ...
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Which immunosuppression caused by long-term usage of these antibiotics in untreated celiac disease?

These antibiotics include amoxicillin + acidum clavulanicum (beta-lactam, inhibit cell wall synthesis, broad specturm, 3rd gen aminopenicillin) / last part preventing the resistance ceftriaxone (3rd ...
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peptide MHC microarray

"The recent technology is peptide–MHC microarray or artificial antigen-presenting chip. In this technique, recombinant peptide–MHC complexes and co-stimulatory molecules are immobilized on a ...
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Do you know of any disease where HLA / MHC association discovery has led to better treatment or management?

If we discover an association between a disease and a particular HLA type (MHC class I or class II molecule) then it may provide us with some insight into the disease in a very basic way. However, ...
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True or False: Vaccines are designed to protect against invaders that are encountered rarely, not all the time

I read the following statement in this article: Vaccines are designed to protect against invaders that are encountered rarely - not all the time Is it true? If yes, why?
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Is the innate immune system capable of identifying all foreign antigens?

I've been studying immunology on my own lately and I would like to know if the macrophages and the other components of the innate immune system are capable of identifying all foreign antigens. As far ...
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Why don't we develop immunity against common cold?

We all suffer from common cold, and that, frequently. Why have we not developed immunity against it till now? By immunity I mean immunity as a species.
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Sequence based method for prediction of continuous B cell epitope

What is Sequence based method for prediction of continuous B cell epitope? What is the algorithm/procedure of this method? Can someone please explain this to me in simple language?
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recombinant peptide MHC complex

What is recombinant peptide-MHC complex??? Recombinant DNA means "to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in biological ...
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Immunomic Microarray

"One can measure two or more signals simultaneously determined by a single feature, i.e., epitope in immunomic microarray DNA microarrays measure one response value for each gene per sample; that ...
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What is hTAP?? Please help

Could not find a single article regarding this. What is hTAP? Tap is Transfer associated protein, that I know, but what is hTAP??(I have not studied biology since last 8 years and now I am going ...
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Why can't the immune system start at the mating time?

The immune system has a great role in our body. When foreign particles enter our body, the immune system can recognize and start defense mechanisms such as the complement system and others. But when ...
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epitope prediction/ mapping

B-CELL EPITOPE PREDICTION Regarding this article: "Such a molecule can be synthesized or, in case of a protein, its gene can be cloned into an expression vector."----- is a particular line in ...
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What is MHC haplotype?

What is MHC haplotype? I did check out the wiki article, but did not understand. (I have not studied biology since last 8 years and now I am going through it because I need it for my research. So if ...
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transfection of expression library made from cDNA into cells expressing the desired MHC haplotypes

http://www.sciencedirect.com/science/article/pii/S0167569997800205 If anybody has access to this paper, can you please explain me the process to find TAA based on transfection of expression library ...
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Difference between sequential and conformational epitope

Is the difference only in its structure? Like conformational epitope has 3D structure while sequential has a linear structure?(I have not studied biology since last 8 years and now I am going through ...
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MHC restricted peptide

What is an MHC restricted peptide? "MHC-restricted antigen recognition, or MHC restriction, refers to the fact that a given T cell will recognize a peptide antigen only when it is bound to a host ...
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Oxidation means inflamation?

All right, I was reading article on nutrition, that focussed on content analysis of pastry-like food product for kids. I have to say that I am not sure this article would pass the imaginary smell ...
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Why is an inflammation in eye and brain more devastating and can lead to loss of organ function compared to other organ like liver etc.? [closed]

Recently I have learnt something about immunoprivileged site and I wonder why these sites like eye would prefer tolerating these antigens that sabotages the normal function of these to having ...
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SEREX serological analysis of cDNA expression library

What is Serological Analysis of cDNA expression library? I went through this article:http://cancerimmunity.org/serex/introduction/ but could not really make out. Can someone please explain this to me ...
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142 views

Complementarity Determining Regions (CDR)

Complementarity determining regions (CDRs) are part of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively, where these molecules ...
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Degenerate Alignment Analysis

Can someone please tell me what is Degenerate alignment analysis? Could not find a good article on the internet that could help me understand what it means? (I have not studied biology since last 8 ...
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Microarray probe and target

In a microarray, which one is called a target and which one is the probe? the one that is added later , is that the probe or the one present in the slots of the microarray, that is the probe? (I have ...