The study of the immune system in organisms, primarily responsible for fighting infection.

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Which process is right to describe V(D)J recombination? RAG-1 and RSS recurring process

I'm studying V(D)J recombination. I think I have two incompatible books about explantaion of the process. Which is right? In Molecular Biology of the Cell 5th Ed., firstly RAG (-1?) combines to RSSs ...
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Human leukocytes (re)circulation/migration in homeostatic state

One can easily find information on the topic of leukocytes trafficking between vessels and peripheral tissues during inflammation. But what happens during normal states when there is no pathology? ...
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eradicating h.pylori naturally

This question is not to discuss whether substances with anti-h.pylori agents works or not, or the pros and cons of such but from a medical perspective. Assuming that one manage to control, reduce, or ...
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Adenosine metabolism

Are adenosine or its catabolites increased in inflamed airways? How can I assess this? I am trying to use inhibitors for adenosine deaminase, xanthine oxidase, and purine nucleoside phosphorylase, but ...
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How does drug-induced photosensitivity work?

Some drugs (tetracyclines, for instance) can cause photosensitivity reactions—that is, some patients become extremely sensitive to the sun, developing rashes or inflammation after spending time ...
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What is NK-cell compartments?

with respect to the paper: Adaptive reconfiguration of the human NK-cell compartment in response to cytomegalovirus: A different perspective of the host-pathogen interaction What is meant by ...
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30 views

What makes substances allergenic?

Is it possible to tell or rule out (potentially a priori) whether any given substance or compound is likely and how likely to cause allergies with high confidence, without the need to conduct ...
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30 views

Subtypes of Acute myeloid leukemia

I am a computer scientist with no biological background and working on analyzing lab results of patients with Acute myeloid leukemia. They have been tagged with following subtypes of AML: AML with ...
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57 views

Is an antivenom venomous?

What happens when someone takes an anti-venom for an animal they weren't bit by, either for incorrect identification of the animal they were bit by or if they weren't bit at all? I am looking for the ...
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87 views

A number of questions regarding chemotaxis assay using PBMCs

In our lab we would like to study the chemotaxis of PBMCs towards conditioned medium obtained following treatment of cancer cells with different compounds. My questions are regarding the method of ...
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63 views

Movement of stem cells from mother to fetus

Recent results from J Lee Nelson and colleagues (Sci Am. 2008 Feb;298(2):64-71; available as full text through Google) show that cells from the mother were found in a person aged 46. Logically, these ...
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Listing Cluster of Differentiation (CD) markers (immunology)

I hope this question is appropriate for this SE. When listing multiple cluster of differentiation (CD) markers to define a cell population, e.g. CD3+CD8+CD45+CD4-, is there a default order to put them ...
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Do bacteria develop a resistance to antimicrobial peptides at the same rate as against “regular” antibiotics?

From what I understand, antimicrobial peptides are roughly grouped into three structural sets, with large variations present between different groups as well as within the groups. Their anti-microbial ...
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Are there any auto-immune diseases caused by T cells not detaching from antigen presenting cells (APCs)?

By not detaching I'm referring to after they have formed an immunological synapse, if they don't ever detach.
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Differences in structural target for LPS detection by LAL and MD-2/TLR4

I remember there being a significant difference in the pathogen-associated molecular patterns (PAMPs) used for detection of lipopolysaccharide (LPS) by mammalian cells and the Limulus amoebocyte ...
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23 views

Sequence based method for prediction of continuous B cell epitope

What is Sequence based method for prediction of continuous B cell epitope? What is the algorithm/procedure of this method? Can someone please explain this to me in simple language?
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How can site-directed mutagenesis be used to suppress the production of anti-antibodies?

In a previous post of mine, I asked how to supress the creation of anti-antibodies in vivo. In the answer, it was mentioned that site-directed mutagenesis could be used. Currently, I can't find mcuh ...