The study of the immune system in organisms, primarily responsible for fighting infection.

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How HIV Affects and Its Treatment using Combination Therapy

Can someone please help me with the following questions. I've written my specific questions right after the text question. Human immunodeficiency virus (HIV) is a retrovirus. Its genome is a single ...
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Using the IMGT/GENE-DB service to find RSS

I'm trying to get the data for the Human and Mouse 12 and 23 Recomination Signal Sequences (RSS), to run a classification algorithm on it. I'm not a biologist, so I apologise in advance for my ...
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Do you know of any disease where HLA / MHC association discovery has led to better treatment or management?

If we discover an association between a disease and a particular HLA type (MHC class I or class II molecule) then it may provide us with some insight into the disease in a very basic way. However, ...
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Adenosine metabolism

Are adenosine or its catabolites increased in inflamed airways? How can I assess this? I am trying to use inhibitors for adenosine deaminase, xanthine oxidase, and purine nucleoside phosphorylase, but ...
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Autoimmunity and central tolerance

Where in the body are self antigens important? In terms of central tolerance and autoimmunity, but also in terms of T cell activation?
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Are there any antigen electronic sensors?

Is it possible somehow to attach antibody to silicon or to other electronic component chemical, and have electronic detector of correspondent antigen? Does such devices exist?
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A number of questions regarding chemotaxis assay using PBMCs

In our lab we would like to study the chemotaxis of PBMCs towards conditioned medium obtained following treatment of cancer cells with different compounds. My questions are regarding the method of ...
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Movement of stem cells from mother to fetus

Recent results from J Lee Nelson and colleagues (Sci Am. 2008 Feb;298(2):64-71; available as full text through Google) show that cells from the mother were found in a person aged 46. Logically, these ...
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Is an antivenom venomous?

What happens when someone takes an anti-venom for an animal they weren't bit by, either for incorrect identification of the animal they were bit by or if they weren't bit at all? I am looking for the ...
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Neutrophil elastase ELISA

I want to do the above assay but by mass spectrophotometry (MS). Hence I need to optimize in MS friendly buffers like formic acid, ammonium formate, ammonium acetate. Has any one done this ...
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What are the effects of excessive UV exposure on the human immune system?

In my readings, several authors have suggested that excessive/prolonged exposure to UV (particularly UVA) can have harmful long term effects on the human immune system. This leads to my question, ...
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Locally sterile immune response in paradoxical IRS coupled with hypersensitivity I

The king of sterile immune response is antibodies; while in unsterile response - T lymphocyte. I think there can be two types of IRS: either abnormalities with T or B cells. Assume the here the case ...
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What Are the Exit Routes of Vaccine Adjuvants?

The digestive and respiratory systems are set up to process externally introduced "stuff." Most vaccines are given via an intramuscular route. What happens to the virus and the adjuvant materials ...
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Biological/molecular basis of nutritional need differences between blood types?

There are many nutrition books and websites (like http://www.aqua4balance.com/Healthy-Diet/blood-type-nutrition-educational-workshop.html) that assign very different nutritional needs to individuals ...