Theoretical models that explain a system using mathematical equations.

learn more… | top users | synonyms

5
votes
0answers
49 views

Hill's function for translational regulation

Transcriptional regulation is generally modeled as a Hill's function (similar to Michaelis-Menten Kinetics): $$\frac{dm_X}{dt}=\alpha _{m_X}.\frac{R}{K+R} -\beta _{m_X}.m_X$$ Where $m_X$ is the mRNA ...
5
votes
0answers
103 views

Model for fluctuating selection

Is there any mathematical model to predict the behaviour and long-term consequence of counter-acting selection at different time scale? For example, let's consider the bi-allelic gene A, with alleles ...
3
votes
0answers
73 views

Experimental techniques to measure protein-protein and protein-ligand structure and dynamics

We would like to compare our simulation results with experimentation. When one wants to follow experimentally the dynamics (and possibly structure) of protein-protein or protein-ligand docking ...
2
votes
0answers
47 views

What is the allelic frequency at mutation-selection-drift equilibrium?

mutation-selection equilibrium At mutation-selection equilibrium the expected frequency $f$ of a given locus is $$f ≈ \frac{\mu}{s\cdot h}$$ , where $\mu$ is the mutation rate, $s$ is the selection ...
2
votes
0answers
19 views

Mutation-drift equilibrium and among loci variance in heterozygosity

At mutation-drift balance, the increased heterozygosity brought by new mutations is exactly equal to the loss of heterozygosity due to genetic drift. At equilibrium, the expected heterozygosity for a ...
2
votes
0answers
80 views

Eye color genetics

I am trying to find a model to link the phenotype eye color to its genotypes. I know that there exists a simple model from Davenport, which explains {brown,blue} eyes. Further, there is an extended ...
1
vote
0answers
22 views

How many traits can a multivariate breeders equation handle?

The multivariate breeders equation (MBE) by Lande predicts the change in a trait $\Delta \bar z$ (response) as $\Delta \bar z = G \beta$ where $G$ is a genetic variance-covariance matrix and ...
1
vote
0answers
39 views

Based on which criteria should i choose the control sample to calculate delta_delta_Ct

I want to calculate the gene expression of an experiment with the Delta delta Ct method. I have these results from two runs of a real time PCR (one for the GOI(Gene of Interest) and one for the ...
1
vote
0answers
57 views

Reverse complement of reconstruction model for assembling reads

One way to assemble fragments produced by DNA sequencing (often called reads) is to seek for the shortest common superstring that contains all the reads of a given set of reads. One model for this ...
0
votes
0answers
21 views

General time reversible model of evolution and Felsenstein model

I would like to get suggestions for the books related to General time reversible model of evolution and Felsenstein model etc. Specifically the mathematical treatment of these topics and concepts ...
0
votes
0answers
31 views

Calculate generations since divergence

Can the formula $\mu = k/(2t + 4Ne)$ be used to calculate the divergence time for any two species given a mutation rate, generation time and sequence divergence value?
0
votes
0answers
73 views

Effects of Genetic Drift on Linkage Disequilibrium

From what I understood of @Canadianer's answer here... Genetic drift randomly causes negative or positive linkage disequilibria, by changing allele frequencies through random sampling. Natural ...