The set of chemical reactions that happen in the cells of living organisms to sustain life.

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Are there any enzymes synthesised by humans that specifically catalyse the hydrolysis of non-cyclic Imides?

Imides or dicarbonyl amides are an interesting class of compounds that includes the pharmaceuticals thalidomide, aniracetam and a few other drugs. These compounds, however, are cyclic and I'm ...
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56 views

Iron metabolism in the brain

I did an expression profiling from publicly available RNAseq data for mouse tissues. While for liver and testes I am getting expected proteins in the top highly expressed mRNAs, for brain I am getting ...
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72 views

Food Intake versus ability to flee among birds, particularly the hummingbird?

Logically speaking, if a hummingbird drinks too much nectar, it will be temporarily overweight and less able or unable to fly to escape danger. However if the same hummingbird doesn't drink enough ...
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33 views

Plotting metabolic networks?

I need to draw a map of the core metabolism of E.coli. Associated with each reaction in the map I have a number that indicates the flux through this reaction. I want the map to reflect these fluxes ...
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55 views

Why Mammals are unable to produce Essential Fatty Acids?

While we have to get them from our diet and if they aren't taken in our diet we will face disease.Then why we don't have the enzymes which are require for EFA synthesis???
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62 views

How is Energy Generated in Cats?

I recall reading that much of the energy a cat produces from its food comes from proteins which I assume would produce energy via being catabolised into amino acids which in turn, if glucogenic, would ...
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62 views

Are simple esters like those used as flavouring agents metabolised into their constituent carboxylic acids and alcohols in the human body?

By this I mean to ask whether say ethyl butanoate is hydrolysed in humans into ethanol and butyric (butanoic) acid. This is of interest to me as a pharmacology researcher because butyric acid, for ...
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34 views

Why are carnivorans more efficient predators than birds or reptiles?

The Wikipedia page on island gigantism says, "Birds and reptiles generally make less efficient large predators than advanced carnivorans. What does it mean for a predator to be "efficient" and why are ...
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52 views

amino acid containing branched side chain

Branched-chain amino acid are degraded by branched chain alpha-keto acid dehydrogenase complex. These amino acids aren't degraded in liver because of the absence of this enzyme(in liver).Why the ...
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24 views

Experimental studies of bacterial adaptation to changes in nutrients of culture medium

Are there experimental studies that measure how a population of bacteria in continuous culture evolve when submitted to changes in the concentrations of metabolites in the culture media? For example, ...
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30 views

Regulation of Cra protein level in E coli

Catabolite Activator/Repressor, Cra protein (formerly known as Fructure Repressor FruR) plays a significant role in central carbon metabolism of E coli. Its activity is inhibited by ...
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53 views

Why is a nicotinamide-tryptophan combination used to treat affective episodes in a few older clinical trials?

At least one of the journal articles that reported on such clinical trials allured to the nicotinamide-tryptophan pathway that I assume must be related to the metabolism of tryptophan into serotonin ...
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22 views

Is there sugar secreted into blood even after complete digestions in healthy humans? What about dogs?

Suppose we're feeding a high GI food to a person and that the digestion lasts five hours. Does the body secrete sugar into the blood afterwards? What about in diabetic dogs and humans? Update: I am ...
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38 views

Poly Unsaturated Fatty Acid

PUFAs spontaneously oxidize, speed up the process of glycation, since too much glucose and they also decrease mitochondrial respiration - more oxygen and CO2, less lactate and PUFA also promote ...
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17 views

What Are the Exit Routes of Vaccine Adjuvants?

The digestive and respiratory systems are set up to process externally introduced "stuff." Most vaccines are given via an intramuscular route. What happens to the virus and the adjuvant materials ...
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46 views

Where can I find complete description of the nucleotide biosynthesis?

I'm looking for a good source for learning nucleotide biosynthesis pathway (including enzymes and possibly also structural formulas) - what is the best source I could find such pathway, presented in a ...
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96 views

How do cells slowly degrade 5,5'-dibromo-4,4'-dichloro-indigo?

5,5'-dibromo-4,4'-dichloro-indigo is the product of X-gal cleavage, often used as a reporter with B-galactosidase. I've made the (unreferenced) observation that it seems as though the blue product ...