Tagged Questions

The major histocompatibility complex is an extremely diverse genome region in vertebrates that is responsible for antigen presentation. There are two main classes, MHC I and MHC II.

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Why cytotoxic T cells don't kill dendritic cells when they present antigen?

When a cytotoxic T cell (CTL) recognizes a peptide presented in the MHC-1 of a dendritic cell (APC), why it doesn't kill this cell? I know that initially, in the lymph node, the T cell is ...
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Presence of MHC on red blood cells

Do red blood cells have no MHC? (I have often heard that they do not.) If so why are they not destroyed by immune cells?
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A possible cause of autoimmunity

I read that Doherty and Zinkernagel found that MHC- heterozygotes present more antigens to the immune system than homozygotes; yet, the infected heterozygous mice in their experiment all ...
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Variation in MHC in humans

What evolutionary process lead to so much variation in MHC? What is the advantage of having such variation?
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Number of MHCs in neurons

I have read that neurons have proportionately less MHC molecules than other cells of the body. What is the advantage of this?
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Do T-cells express MHC molecules?

T-cells recognize the MHC molecules and body's own peptides. When it doesn't, it alarms the immune system. But do T-cells express MHC molecules ? If so, how are they using it? If not, what happens ...