The study of evolutionary mechanisms in operation at the molecular scale, primarily DNA, RNA, and proteins.

learn more… | top users | synonyms

4
votes
0answers
115 views

At what rate do chromosomal rearrangements occur?

How often does chromosomal rearrangements occur? i.e. what is the rate of chromosomal rearrangements? I am interested about these kind of chromosomal rearrangements that are passed on to the ...
3
votes
0answers
65 views

Inbreeding Coefficient and Coefficient of Relationship

Wikipedia gives the following formula to calculate a "path of coefficient of relationship" between an ancestor $A$ and an offspring $O$: $$\rho_{AO} = 2^{-n} \left( \frac{1+f_A}{1+f_O} \right)^{1/2} ...
2
votes
0answers
35 views

Do The Traces Genetic Diseases Remain in families?

I know that there are certain diseases that are predominant on genes. But, is there any sort of surety that if parents are suffering from a disorder then their offspring has to suffer from the same. ...
2
votes
0answers
58 views

Odds of Fusion of Chromosome #2

There is strong evidence that chromosome 2 in humans is a fusion of two chimp chromosomes (i.e. common ancestor of chimps and humans) as explained at wikipedia here The question is what are the odds ...
1
vote
0answers
32 views

Identity By Descent vs Identity By State

Background The concepts of Identity By Descent (IBD) vs Identity By State (IBS) are central in population genetics, yet I fail to fully wrap my head around the definitions. You can find examples ...
1
vote
0answers
16 views

How is “fine mapping of pelvic regulatory region” done in the stickleback PitX1 paper?

I'm working through this paper for a class. I'm a bit confused by the methods they used in one experiment. So the researchers are studying spine development in stickleback fish. They noticed some ...
1
vote
0answers
58 views

What genetic distance model should be used when calculating genetic differences in Arelquin?

I'm using Arelquin to look at the genetic structure between a number of different populations. I want to compare the populations by producing pairwise FST values, however I don't know what model for ...
1
vote
0answers
52 views

How far in evolutionary distance is the P-distance estimator “accurate”?

I'm reading Yang's computational molecular evolution and in the very first chapter it says the P distance is a "simplistic distance measure" between two sequences. It is the number of different sites ...
0
votes
0answers
23 views

How does epigenetics affect the birth conditions via alcohol?

Recent study has shown that epigenetics can play role in male-caused infertility and it cites for example studies which showed an enhancing of silent genes when drinking alcohol. Since the study ...
0
votes
0answers
14 views

Ewens-Watterson Test of Neutrality

The Ewens-Watterson test is one of the first test of neutrality (of no selection). Later came tests such as Tajima's D or Fu, Li's G and many other. Question Can you please make a description of how ...
0
votes
0answers
21 views

Separate replication origin and terminus vs making them one and the same

The classical picture of bacterial reproduction has a replication origin on one side of the circular chromosome and a replication termination area on the opposite end. This essentially creates two ...