A change in an organism's genomic sequence.

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Open Source Variant Caller comparable to GATK Haplotype Caller?

Is there a Variant Caller comparable algorithmically and in performance to GATK Haplotype Caller but Open Source Compliant (non-restrictive use)?
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1answer
31 views

Somatic Mutations in meristem tissue in plants

In angiosperm, in which layer of the meristem does a new mitotic mutation occurring has chance to be found in a pollen grain or in an ovule? I also welcome some insights about non-angiosperm plants.
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65 views

At what rate do chromosomal rearrangements occur?

How often does chromosomal rearrangements occur? i.e. what is the rate of chromosomal rearrangements? I am interested about these kind of chromosomal rearrangements that are passed on to the ...
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1answer
19 views

What is the difference between a DPY-10, DPY-11, and DPY-13?

My TA mentioned these three mutations of C. elegans since we started working with the worms but seems to skip over what the differences are...
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2answers
44 views

Are there known downsides to removing UV mutation hotspots to prevent some skin cancers (Genetic sunblock)?

Khavari et al. recently demonstrated that a significant fraction of one of the major forms of skin cancer (cutaneous squamous cell carcinomas) are associated with a mutated KNSTRN gene (a protein ...
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61 views

Is the mutation rate in organisms in general consistent over the genome?

Coming from computer science with an interest in genetic programming (a process emulating evolution) I'm curious about whether the rate of mutation is homogeneous across the whole genome, or if some ...
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2answers
24 views

Does chromosomal crossover result in a mutation?

Is chromosomal crossover considered a mutation? Would this be a large-scale mutation?
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2answers
88 views

(How) can a pink grasshopper exist?

I saw this foto on Reddit recently: Is this possible? How can a grasshopper become like this? Is this just natural genetic mutation?
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1answer
39 views

Percentage of mutations caused by radiation?

Consider a gamete in a typical human being. In the interest of being specific, let us say that we're talking about a typical ovum in a typical middle class woman living in a developed nation. What ...
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1answer
15 views

Are efflux pumps mutations or are they originally present in N. gonorrhoea?

I'll start by saying that I am no biologist. I am a math major trying to create a mathematical model for gonorrhea strain competition. My assignment is to create a model similar to a model that was ...
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2answers
187 views

What if a Point Mutation is seen in only half the coverage for its location?

I've been looking at some sequenced exomes and found an interesting point mutation that causes a Proline-to-Leucine amino acid change in the protein. This seems like it could have a big impact on the ...
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4answers
81 views

Which point mutations in proteins are OK, and which cause significant change?

I heard that some point mutations in proteins are OK, like from alanine to glycine (I'm not sure, it's just an example), some will change the protein significantly. I want to understand deeper but ...
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95 views

Are all mutagens carcinogens?

Not all carcinogens are mutagens. Alcohol and estrogen, for example, do not damage DNA. It's one of the assumptions of the Ames test that mutagenicity implies carcinogenicity, but is this always the ...
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59 views

What are the naming conventions for mutations of proteins?

I have been reading about Maltose Binding Proteins. Mutant forms of the molecule seem to be named MalE_ where the _ represents a number, for example MalE36 or MalE50. Please can someone explain the ...
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31 views

Penetrance Calculation of a Spontaneous Mutation

I'm trying to estimate the penetrance of a disease in a population given a rare spontaneous mutation that confers predisposition in an autosomal dominant manner. Given that the mutation is ...
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3answers
156 views

Why cancer mutations do accumulate sequentially?

According to Knudson hypothesis, cancer mutations accumulate in order. Statistics says, that cancer probability increases as sixth order of age, which may mean six consequential steps to cancer. But, ...
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1answer
29 views

Is it firmly established, that mutations are sufficient for cancer?

It is evident for scientists, that all cancer cells have some mutated genes. Say mutations in general. But this evidence means necessary condition. But what about sufficient conditions? Is it ...
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1answer
46 views

Most human-like teratoma ever recorded?

I'm curious to learn about the most human teratoma ever recorded. By most human I mean the teratoma which most resembles the form of a human being. I suppose there are several criteria which would ...
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1answer
64 views

Population Genetics Question

Can someone please help with this question? Here is my working (just in case it is not clear: 1/300*1/30*1/2) but is this actually correct or do I need to multiply by 0.5 once again? I appreciate ...
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0answers
33 views

What is TILLING?

How does TILLING (Targeting Induced Local Lesions in Genomes) work? What is needed to perform a TILLING experiment, and what kind of information can we get out of it?
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3answers
71 views

How does mutation cause natural selection? and is it common in protists or prokaryotes?

Why is it inevitable that evolution by mutations alone should be a common cause of evolutionary change in most natural populations? And do you expect mutation-driven evolution to be more common in ...
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2answers
89 views

Effect on fitness of mutations

What is the distribution/probability density function (PDF) of impacts on fitness of new mutations? I very welcome any partial answer that does not give the whole PDF but just some information ...
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1answer
38 views

Dominance/recessivity of new mutations

What is the distribution/probability density function (PDF) of recessivity/dominance of new mutations? I very welcome any partial answer that does not give the whole PDF but just some information ...
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1answer
369 views

What is the standing genetic variation?

I am reading this review. In the first part, the author introduces Standing Genetic Variation, described as: STANDING GENETIC VARIATION Allelic variation that is currently segregating within a ...
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1answer
43 views

Is it possible to elicit transient gene silencing by using virus induced gene silencing (VIGS) in plants?

I am looking for a molecular tech' which could result in transient gene silencing in plants. The objective is to not make transgenic plant, but to use these tech' to silence a gene of interest for a ...
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1answer
46 views

Quorum Sensing in Vibrio cholerae

This is a figure summarising the quorum sensing mechanism in Vibrio cholerae. In this video by Bonnie Bassler, she explains how quorum sensing can be targeted to control infections. At 15:09 she ...
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3answers
154 views

Evolution (Reductionism)

My recent post was tagged as unclear so I wanted to re frame my question. Though I am a layman, I would love to read books and find the stuff, if I get an overall picture of intelligence factor. My ...
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4answers
63 views

What evidence do we have to derive a rate of evolution?

When analyzing how the human species evolved and will continue to evolve over time, what evidence and tools (theory/models) do we have available to derive the rate at which this happens? Is it even ...
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1answer
179 views

How do scientists create specific mutations?

Suppose I want to create a mutant like Antennapaedia how will I go about accomplishing it ? I know that radiation and certain chemicals are mutagenic. So do scientists subject animals to such ...
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1answer
65 views

Mutation rate in viruses

Mutation rate is a phenotypic trait that evolves. The process of evolution of such kind of traits are often referred to as evolvability. I am wondering about the evolution of the mutation rates in ...
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1answer
31 views

Constitutive mutation in operator gene

If a constitutive mutation happens in the operator of an inducible operon, does that mean that repressors won't be able to bind them ? Or does it mean that even if repressors are bound, they will not ...
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1answer
90 views

Carcinogens, how do they work?

The easiest carcinogenic thing for me to grasp is radiation, as it directly messes with DNA. Then it seems there are other compounds that simply mimic hormones, but these shouldn't necessarily cause ...
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1answer
125 views

How can synonymous mutations lead to cancerous or tumorous phenotypes?

After analyzing DNA sequences of an oncogene from many human cancer patients, you found that synonymous substitutions occur in a specific codon of this oncogene. Assuming that these synonymous ...
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1answer
100 views

Can cancer cells in the same person, organ, and origin have different DNA?

Is it possible for cells from the same tumor to have different genetic material, and if so, to what degree is it possible (how fast do they mutate) ?
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2answers
93 views

Ethidium bromide and mutagenesis on cloning

When performing a DNA cloning, sometimes PCR amplicon is run in agarose and it is detected by ethidium bromide marking under UV light. After that, gel is sliced, DNA extracted from gel....... until ...
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1answer
53 views

Mutation in pre-mRNA sequence

Has there any mutations been recorded which cause harmful effects due to change in the part of pre-mRNA responsible for proper m-RNA splicing ?
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252 views

Correlation between genome size and mutation rate?

Martin Nowak in his book "Evolutionary Dynamics" talks about a given correlation between genome size and mutation rate. What correlation does exactly exist between these two concepts? Is it a ...
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2answers
98 views

How does smoking, an environmental factor, cause cancer, fundamentally a genetic disease?

If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking cause cancer?
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1answer
62 views

How well supported is the hypothesis that aging is mainly caused by the number of mutations in tissues?

I heard the hypothesis, that the (main) reason of aging is the increasing number of mutations in body tissues. The higher the number of mutations is, the older tissue is. Is this true? And how well ...
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1answer
1k views

Difference between mutation and DNA damage

What is the strict difference between mutation and DNA damage? As far as I understand it, a mutation is an alteration in the genetic sequence, having "tricked" the repairing machinery and thus ...
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1answer
31 views

Genotoxic agent and their metabolic pathway

What are the mechanics (set of biochemical reactions) allowing a given genotoxic agent to modify the mutation rate at a given spot? to induce only a given type of mutation (from Gs to Cs for ...
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1answer
95 views

Bacterial division and mutation rate

When a bacteria A divides it produces two cells A', A''. Each of them receives a copy of the chromosome/plasmids. Now, DNA replication occurs way before division in a semiconservative manner. That is, ...
4
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1answer
71 views

Transcriptionally-mediated DNA damage

I'm researching the genetics of brain cancer, and finding a huge number of mutations in voltage-gated channels. It stands to reason that some of this DNA damage is due to the DNA being transcribed ...
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2answers
217 views

variation in antigen binding site of antibodies

Antibodies or immunoglobulins are proteins made ​​by the immune system in response to alien(!) molecules. Each antibody binds to its specific antigen. This great diversity and specificity is cause of ...
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1answer
23 views

Mutation in axillary buds of trees overcoming self-incompatability?

I seem to recall from either reading or lecture that there have been instances of trees that are self-incompatible accumulating enough mutations in an axillary bud that the resulting branch was able ...
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1answer
55 views

Arabidopsis thaliana RCSB active site gene mutant

I'm looking for an Arabidopsis thaliana gene listed in RCSB with a clear mode of function and active site. In addition it needs to have an obvious phenotype when knocked out like severely retarded ...
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1answer
94 views

Which cells will pass cancer to offspring?

Each of these types below contains a DNA mutation. Which type(s) will affect the children of the individual whose cell it is. Red blood cell T cell Skin (epithelial) cell Neuron from the brain Sperm ...
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1answer
119 views

Mutation-immunity in Luria-Delbruck experiment

If experiments like those of Luria and Delbruck on E. coli and T1 phage are the main source of our confidence in the mutation-immunity model, is it then highly unlikely that there are other types of ...
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2answers
68 views

Is vision a vestigial sense for deep ocean species?

Sunlight doesn't penetrate beyond a couple of hundred feet from the surface of the ocean. Species that exist at greater depth probably live in a state of perpetual night; yet from a quick google image ...
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227 views

Have there been attempts to identify Chomsky's “language mutation” in humans?

I'm not versed in either biology or linguistics so please forgive any naiveties I may commit. I've learned that Noam Chomsky thinks that language is a result of a single genetic mutation in humans. ...