A change in an organism's genomic sequence.

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331 views

Correlation between genome size and mutation rate?

Martin Nowak in his book "Evolutionary Dynamics" talks about a given correlation between genome size and mutation rate. What correlation does exactly exist between these two concepts? Is it a ...
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2answers
135 views

How does smoking, an environmental factor, cause cancer, fundamentally a genetic disease?

If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking cause cancer?
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1answer
67 views

How well supported is the hypothesis that aging is mainly caused by the number of mutations in tissues?

I heard the hypothesis, that the (main) reason of aging is the increasing number of mutations in body tissues. The higher the number of mutations is, the older tissue is. Is this true? And how well ...
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1answer
2k views

Difference between mutation and DNA damage

What is the strict difference between mutation and DNA damage? As far as I understand it, a mutation is an alteration in the genetic sequence, having "tricked" the repairing machinery and thus ...
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1answer
34 views

Genotoxic agent and their metabolic pathway

What are the mechanics (set of biochemical reactions) allowing a given genotoxic agent to modify the mutation rate at a given spot? to induce only a given type of mutation (from Gs to Cs for ...
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1answer
109 views

Bacterial division and mutation rate

When a bacteria A divides it produces two cells A', A''. Each of them receives a copy of the chromosome/plasmids. Now, DNA replication occurs way before division in a semiconservative manner. That is, ...
4
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1answer
72 views

Transcriptionally-mediated DNA damage

I'm researching the genetics of brain cancer, and finding a huge number of mutations in voltage-gated channels. It stands to reason that some of this DNA damage is due to the DNA being transcribed ...
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2answers
277 views

variation in antigen binding site of antibodies

Antibodies or immunoglobulins are proteins made ​​by the immune system in response to alien(!) molecules. Each antibody binds to its specific antigen. This great diversity and specificity is cause of ...
3
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1answer
26 views

Mutation in axillary buds of trees overcoming self-incompatability?

I seem to recall from either reading or lecture that there have been instances of trees that are self-incompatible accumulating enough mutations in an axillary bud that the resulting branch was able ...
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1answer
58 views

Arabidopsis thaliana RCSB active site gene mutant

I'm looking for an Arabidopsis thaliana gene listed in RCSB with a clear mode of function and active site. In addition it needs to have an obvious phenotype when knocked out like severely retarded ...
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1answer
101 views

Which cells will pass cancer to offspring?

Each of these types below contains a DNA mutation. Which type(s) will affect the children of the individual whose cell it is. Red blood cell T cell Skin (epithelial) cell Neuron from the brain Sperm ...
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1answer
132 views

Mutation-immunity in Luria-Delbruck experiment

If experiments like those of Luria and Delbruck on E. coli and T1 phage are the main source of our confidence in the mutation-immunity model, is it then highly unlikely that there are other types of ...
3
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2answers
82 views

Is vision a vestigial sense for deep ocean species?

Sunlight doesn't penetrate beyond a couple of hundred feet from the surface of the ocean. Species that exist at greater depth probably live in a state of perpetual night; yet from a quick google image ...
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1answer
253 views

Have there been attempts to identify Chomsky's “language mutation” in humans?

I'm not versed in either biology or linguistics so please forgive any naiveties I may commit. I've learned that Noam Chomsky thinks that language is a result of a single genetic mutation in humans. ...
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0answers
68 views

Are mature trees as susceptible to mutation from exposure to radiation as seedlings?

If a plant, say a ficus or a teak, as a sapling were exposed to radiation, and a tree of the same species were present at the same distance, which of the two would be more likely to mutate?
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2answers
526 views

Which bacteria have the highest mutation rate?

From my reading on M. tuberculosis, I know that this organism has a pretty high mutation rate due to uncorrected sloppy replication, which leads to a high rate of development of spontaneous resistance ...
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3answers
346 views

Number of beneficial mutations cataloged?

I can see from Wikipedia that there are possibly thousands of harmful mutations that have been cataloged and linked to disease. There are also unnumbered neutral mutations. But, does anyone know how ...
3
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1answer
308 views

Predicting progeny of recessive mutations using recombination

I was asked this question on a test and got it wrong, but I'd like to know how to do it. The answers are shown in the blanks below: You are studying two recessive mutations in the fruit fly D. ...
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1answer
374 views

Looking for a cancer drug target database to guide sequencing of patient tumor DNA

I have a question I would like to pose to the community. I have recently received access to a bench-top ion torrent DNA sequencer. Our idea is to use this machine to sequence the DNA from patient’s ...
9
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1answer
444 views

What is the modern state of the theory of evolution?

When I studied biology at my medical school we used to learn things about a century old: the famous Darwin's voyage on "Beagle" to the Galapagos Islands, the classical triad of his Theory of ...