A change in an organism's genomic sequence.

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7
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3answers
99 views

Following DNA replication during S-phase of the cell-cycle, are all genomic regions subjected to the same stringent level of DNA-Repair?

To my (limited) understanding, there are 2 main ways that mutations can occur in DNA: Environmental (UV, etc) and mistakes during cell division. I was wondering if there is a mechanism that can give ...
4
votes
2answers
81 views

Is it possible to have different genes in different parts of our body?

I want to understand genetic mutation specially in the context of multicellular organisms like humans. I studied biology only till high school and I can’t fully understand wikipedia pages on this ...
1
vote
1answer
59 views

Pink Grasshoppers

The area I found this grasshopper was Canyon Country, California, USA In a desert/field area. I have been reading up on grasshoppers because I recently came into possession of a pink grasshopper (It ...
4
votes
0answers
113 views

At what rate do chromosomal rearrangements occur?

How often does chromosomal rearrangements occur? i.e. what is the rate of chromosomal rearrangements? I am interested about these kind of chromosomal rearrangements that are passed on to the ...
3
votes
0answers
24 views

Inter-codon mutations statistical analysis

I am looking for a statistical approach to inter-codon mutations. For example a 64*64 (64*63 actually) table, that contain the possibility of mutation from one codon to another codon (CCA to CAA or ...
3
votes
0answers
80 views

Are mature trees as susceptible to mutation from exposure to radiation as seedlings?

If a plant, say a ficus or a teak, as a sapling were exposed to radiation, and a tree of the same species were present at the same distance, which of the two would be more likely to mutate?
2
votes
0answers
27 views

How to determine suitable Cysteine mutations?

In the lab, I'd like to generate a dimer of a protein via disulfide bonds. The interface between the two looks as follows: Now, in the interface, there isn't any cystein I could use to dimerize the ...
2
votes
0answers
36 views

Can ' functional' stress 'forced upon' a cell actually cause cell mutations when they divide and reproduce?

If a group of cells are forced to go beyond their regular biological parameters that they should be under given ' healthy' functioning and while existing in these stressed states some of the cells ...
2
votes
0answers
26 views

Can mutation rate be increased for instance by mutagenesis targeting the DNA polymerase?

I am studying a non-cultivable bacterium living in an insect host, and I would like to generate some random mutants of this bacteria while preserving the insect. I am wondering if one way to do so ...
2
votes
0answers
49 views

What is TILLING?

How does TILLING (Targeting Induced Local Lesions in Genomes) work? What is needed to perform a TILLING experiment, and what kind of information can we get out of it?
1
vote
0answers
67 views

What type of point mutation and chromosomal mutation cause Albinism in humans?

First of all, I know that OCA1 (Oculocutaneous Albinism Type 1) is autosomal recessive which means that both parents-who are unaffected-have to pass down one copy of a mutated gene in order to ...
1
vote
0answers
30 views

Will someone with a double mutation in the allosomes be normal?

Normally a female human has an X allosome from her father and an X allosome form her mother. What if an double mutation happened, which causes that someone has two X allosomes form her mother and no ...
1
vote
0answers
33 views

There are 6 classifications of CFTR mutations. Is a causal relationship to the sweat test known?

Cystic fibrosis (CF) is caused by mutations in the gene for the protein cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR mutations are classified in 6 classes. The sweat test is ...
1
vote
0answers
28 views

Genetic tests on S. cerevisiae to determine mutation locus on genes

I am studying the metabolism of galactose in the budding yeast Saccharomyces cerevisiae. After a random mutagenesis screen, several mutant strains were isolated that grow well in glucose but are ...
1
vote
0answers
50 views

Open Source Variant Caller comparable to GATK Haplotype Caller?

Is there a Variant Caller comparable algorithmically and in performance to GATK Haplotype Caller but Open Source Compliant (non-restrictive use)?
0
votes
0answers
12 views

Finding SNPs and Haplotypes?

I have the following alignment file. How can I identify the SNP sites and how can I find the haplotypes. I know these are related but can't seem to apply it to the below data. Any help would be ...
0
votes
0answers
48 views

mutant and variant differentiation

Can anyone clearly differentiate between a variant and a mutant in genetics. I am confusing these terms a bit, as the evolutionary aspect also comes to my mind.
0
votes
0answers
13 views

coverage of amplicons and mutation analysis with IGV

Q1: I want to understand why the coverage of each amplicons varies for these 4 different amplicons (exon 18 is almost 10 times lower). Is this difference caused during the amplification phase (PCR)? ...
0
votes
0answers
51 views

Are there any non-harmful viruses that can alter a specific mutation?

Are there any non-harmful viruses that in going into a cell and using the cells 'machinery' and genetics to 'copy' itself actually changes some of the cells genome , maybe altering some mutations? ...
-1
votes
0answers
12 views

Asexual reproduction of snakes, with mutation to account for diversity

I saw this piece on Animal planet's Jeff Corwin show, I think. It was many many years ago, but I still remember it was fascinating. A landslide or an earthquake once separated a small chunk of land ...