The theory by which mutations in the genetic code lead to differences from the previous phenotype that, should they be advantageous to an organism's survival to reproductive age, may be passed on to offspring.

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Model for fluctuating selection

Is there any mathematical model to predict the behaviour and long-term consequence of counter-acting selection at different time scale? For example, let's consider the bi-allelic gene $A$, with ...
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Reformulation of Hamiton's rule

Who (and in which article) was the first to reformulate Hamilton's rule using the letters $B$ and $C$?. See below comments on this reformulation. Hamilton, in his 1964's article gave a mathematical ...
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effect of background selection on promoter regions compared to distant enhancers?

Has anyone looked at the effect of background selection on the levels of conservation of promoter regions compared to distant enhancers? Do promoter regions have a higher conservation due to ...
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How does Natural Selection shape Genetic Variation?

Background Importance of the additive genetic variance As stated here, the fundamental theorem of Natural Selection (NS) by Fisher says: The rate of increase in the mean fitness of any organism ...
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Intuitive explanation for Kin- and Group- selection

It is known from theoretician in the field of kin selection that kin selection (inclusive fitness theory) and group selection are actually two sides of the same coin. In other words, these two ...
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Ancestral states of sex determination system

Most (maybe all?) species that reproduce sexually have either genders (anisogamy) or mating types (isogamy). There exist today many different type of sexual determination system. There is a whole ...
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What is most ancestral: isogamy or anisogamy?

Sexual reproduction can be feasible with anisogamy (gametes of different sizes i.e. genders) or isogamy (gametes of same size i.e. mating types) or with undifferentiated gametes (i.e. true random ...
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Mutation-drift equilibrium and among loci variance in heterozygosity

At mutation-drift balance, the increased heterozygosity brought by new mutations is exactly equal to the loss of heterozygosity due to genetic drift. At equilibrium, the expected heterozygosity for a ...
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Is there an evolutionary explanation for depression?

Evolutionarily speaking, depression (both clinical depression and temporary sadness) is a curious phenomenon. Since being depressed is likely to increase the chance of a person with it to commit ...
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Source of information on the evolution of aging/senescence

Do you know a good review (published peer-reviewed or an online course or whatever) that offers a good overview of all hypothesis explaining the various patterns linked with aging? I'd like this ...
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Niche differentiation in birds of prey

I'm not much of an ornithologist but I know enough to distinguish most Central European birds of prey. To me it is amazing that there are so many species that seem to occupy the same niche. Especially ...
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detection of primary origin (natural selection or genetic drift) on alterations in sequences

I recently had a question about how to distinguish the origin of variations in the sequences of rRNA as to whether alterations are generated by genetic drift or natural selection. For me it has not ...
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$F_{ST}$ and the genetic variance in metapopulations

From this video (21'15''), the speaker gives the following formulae in order to calculate the between and among populations genetic variance from the $F_{ST}$: $$V_{Among Pop} = 2 F_{ST}V_G$$ ...
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Cost of Substitution explained

I've recently come across an article that mentions "Cost of Substitution" and was wondering if someone can give me a real layman's term explanation of what that is. (Edited:) This was in relation to ...
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Why are there no animals with a length greater than 30-40 meters or with a mass greater than 200 tonnes?

The biggest and heaviest aquatic animal is the blue whale: 30 meters long and a mass of 200 tonnes. The biggest and heaviest terrestrial animal was a Sauropod (plant-eating, long-necked dinosaur): 40 ...
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21 views

coevolution by physical interaction between RNA sequences

There are several items that relate to the concerted evolution between pairs of sencuencias (especially structural) rRNA as a consequence of physical interaction in tertiary, or even quaternary ...
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Effects of Genetic Drift on Linkage Disequilibrium

From what I understood of @Canadianer's answer here... Genetic drift randomly causes negative or positive linkage disequilibria, by changing allele frequencies through random sampling. Natural ...
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Effect of natural selection on phenotypic variance

Short background Theoretically speaking, natural selection causes a decrease in genetic variance and because the environmental variance should remain unchanged, natural selection causes a decrease of ...