Neurodegenerative disorders are disorders characterised by progressive neuronal cell death.

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Are axons capable of endocytosis?

There is evidence for the uptake of toxic substances like prions from the cell bodies of neurons via endocytosis (e.g. described here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892479/). There is ...
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How much should one smoke in order to prevent Parkinson's? [closed]

There are studies who claim that nicotine has a neuroprotective effect against Parkinson's(such as this: http://www.ncbi.nlm.nih.gov/pubmed/11772120) What would be the minimum amount of ...
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38 views

Of people who develop Alzheimer disease, are those people genetically predisposed to it?

I have read a lot lately about microbiological pathogens that are found in blood vessels in the brain of patient's with Alzheimer disease (positive association). So, I am confused whether there are ...
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Where can I find epigenetics related microarray dataset for Alzheimer and Parkinson diseases?

In my thesis project, one of the tasks regards co-expression network analysis for epigenetics (methylation) data. In GEO and Array Express repositories, I have already searched for the microarray ...
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1answer
45 views

Why to use transgenic mice in ALS models?

In ALS mice model with mutant SOD1 - there are use of transgenic mice, with insert of human mutant SOD1. Why is that? Why not to mutate directly mice SOD1 ? In transgenic mice, after few generations ...
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73 views

Why does ALS start in middle age?

Amyotrophic lateral sclerosis (ALS) often starts at middle age, but I didn't find any suggestion why. Something seems to trigger the symptoms in middle age. If I am not mistaken, the sporadic ALS is ...
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199 views

What is the mechanism behind tinnitus?

I seem to have come across two contrasting explanations for tinnitus induced by loud noises- i.e. damage to the hair cells in the cochlea. On the one hand, I have read that damage to the hair cells ...
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5k views

Why do adults lose hearing at high frequencies?

Children and teens can hear high pitched sounds that adults can't hear anymore. Why do adults lose high-frequency hearing?
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376 views

Does breath-holding cause permanent brain damage?

My question is: Does voluntarily holding your breath at atmospheric pressure for a few minutes can cause brain damage? I'm talking about periods of time around 3 minutes. I've read there are some ...
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109 views

Congenital blindness due to retinitis pigmentosa - does it exist?

Retinitis pigmentosa (RP) patients typically become blind after a period of years in which their eye sight slowly deteriorates due to photoreceptor degeneration. Generally RP patients develop ...
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1answer
100 views

Do insomniacs yawn?

According to wikipedia, the jury is still out on the function a yawn serves. The article referenced above however writes to say Yawning most often occurs in adults immediately before and after ...
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55 views

The use of proteins in memory creation

I have very limited knowledge of how the human memory works as I think, at this time, most people do. However, I have been reading and some articles which say, and I quote the article just linked ...
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2answers
103 views

What causes autism?

What causes autism? By this I don't mean what is to blame i.e. Vaccines, Gluten or Pharmaceuticals etc.. I mean what exactly is happening in the brain to cause the autistic behaviors such as little ...
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What are some of the immediate challenges to break through before finding a cure for mad cow disease?

What are the immediate challenges to break through in seeking a cure for mad cow disease? I know that mad cow disease has no treatment as of yet.
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472 views

What factors govern the variable age of onset in Huntington's Disease?

"Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems." As we all know, this genetic disease ...
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What does effect would Sulforaphane have on Kennedy's Disease?

Sulforaphane is a isothiocyanate found in cruciferous vegetables including broccoli and cauliflower. Its 2D structure is as follows: It's been found to serve as a histone deacetylase 6 (HDAC6) ...