The study of the structure and function of the nervous system and its components.

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How does the brain develop different parts?

The mammalian brain contains many parts which perform specialized functions. However, the actual mechanical makeup (neurons) are mostly homogenous throughout the brain. After a brain achieves ...
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28 views

Forgot to cool slides before washing

I just finished an immunofluorescence experiment and I'm wondering what went wrong. The tissues seem dimmer than they should be. One mistake I made was: I completed the antigen retrieval step, in a ...
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5 views

Feedback mechanisms for the dynorphin-kappa opioid system?

(this is all happening in the brain). Also it's best to go context-first I think (1) Normally if you take an agonist drug that hits a receptor "x", eventually the brain will downregulate the density ...
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59 views

Why are so many recreational drugs serotonin 5-HT1A partial agonists?

I found out that many psychoactive drugs partially activate the 5HT1A receptor. Looking at Wikipedia, these include MDMA, LSD, CBD, Psliocybin/Psilocin, amphetamine and various other psychedelics, and ...
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26 views

How does stimulus reach neural threshold?

I understand that when the stimulus into a neuron is greater than the threshold it triggers the action potential. Do all the contributing stimulus have to occur at the same time, or can they occur ...
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1answer
64 views

How do heredity and regression to the mean work with respect to intelligence?

I am trying to understand the heredity of intelligence between generations in general, and how regression to the mean works in detail in particular. The answer I'm looking for should preferably answer ...
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43 views

Is there an evolutionary advantage associated with migraine? [duplicate]

I have read Wikipedia article on Genetics of migraine headaches and I don't buy it Because genetics influence susceptibility to migraine, it can be shaped by evolution. Fitness-impairing ...
14
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1answer
151 views

What's the mechanism for being mentally tired?

I notice that after long tests, or long periods of critical thinking, my body and mind feel noticeably tired. Why does this happen? Are the neurons in my head not firing as quickly, or is there just a ...
4
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1answer
79 views

Is there a biological explanation for perceived deeper cognition whilst on cannabis?

Cannabis has been associated with literature, arts, and culture for centuries. There are a few features of the drugs affect on the human mind that account for this, however it remains illegal in most ...
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29 views

Nerve endings on the skin

We can perceive sensation of pain if we are poked on any part of the skin. Does this mean there is a nerve ending at every point on the skin? Does this also mean that each of these nerves go all ...
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1answer
52 views

Where exactly is pleasure

Question from an outsider: have we been able to pinpoint where exactly the feeling of pleasure comes from? I know that there are several types of pleasure, I'm talking about the 'liking'. If that ...
3
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1answer
39 views

What are tail currents?

This is a voltage clamp on an ion channel. When the voltage is stopped there is a still a current at the end (the tail current). I understand that the gates aren't completely closed because of which ...
5
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2answers
72 views

How does the brain know what to remember and what not?

People remember some information for example when learning for an exam, or remember to go to a shop after work etc., but we don't remember usually much other stuff like people passing us, what was the ...
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46 views

What happens to the human brain when unconscious?

What part of the brain gets affected and does it harm the brain? Thank you I just needed some extra info for a video I'm making.
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1answer
33 views

What information do bipolar cells encode?

Short version: I don't see what information on-centre bipolar cells are actually capturing. Longer: Actually, the question could be extended to on-centre retinal cells as well, but I'll focus on ...
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1answer
23 views

Voltage sensitive dyes technique: What is the underlying measure?

I just discovered voltage sensitive dyes technique: first of all what imaging techniques do we use? And I have seen that figures are labeled with ΔF/F0, what does it stands for?
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4answers
1k views

Is it possible to feel pain in some part of a body, but the pain “feeling” is introduced somewhere else?

Is it possible to feel pain in some part of a body, but that the cause of the pain is situated elsewhere in the body? For example, somebody feels pain in his toe, but it turns out that this pain is ...
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29 views

Where to go next with clustered C elegans neuronal time series

I'm doing some independent research with the C Elegans nervous system (with the OpenWorm project) and was looking for some guidance as to where I should go next. Right now, I'm dealing with calcium ...
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28 views

Do ion channels block at these temperatures?

I found this paper and it says nerve axons cold block at temperatures near 0C. http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.1968.sp008656/pdf Does this mean ion channels also block (due to ...
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2answers
58 views

Does the creation of memory involve mRNAs crossing the synaptic gap?

There is a diagram from a book titled "Teaching with the brain in mind". The diagram shows The diagram appears to show that the "creation of memory" involves "messages coded by RNA" moving through ...
3
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1answer
56 views

How can neurons divide without centrioles?

I have read in my studies that neurons lack centrioles. If that is so, then how is it possible that new neurons are added to our brain? Does this have anything to do with memory loss?
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21 views

How much yogurt would one have to consume to have a noticeable effect on neurotransmitters [closed]

I read several recent articles that proposed a link between bacteria in our gut and neurotransmitters in our brain. For instance http://www.ncbi.nlm.nih.gov/m/pubmed/24997036/ I am curious how much ...
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16 views

Why do fishes have both a gustatory and an olfactory system?

I would like to know if there is a know reason for which fishes (and many aquatic species) have both an olfactory and a gustatory system. As far as I know, in all fish species the chemoreceptors, ...
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1answer
24 views

Analysing the ERP (Event-Related Potential from EEG recordings) in terms of the P-300 wave

I am trying to understand how to analyze ERP (Event-Related Potentials) from EEG recordings in focus on P-300 waves. I have come up with a few questions which I hope you might be able to help with: ...
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1answer
39 views

Why is active transport needed in repolarization?

During the repolarization phase of an action potential, the potassium ions diffuse out of the cell, and active transport begins. What I do not understand is why active transport is needed when the ...
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1answer
90 views

How does the synaptic cleft exist?

I'm not asking why the synaptic cleft exists, i.e. what function it holds, rather how. So I know that the neurotransmitter diffuses across it, it is 20-40 nm wide and contains basal lamina (in NMJs at ...
3
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1answer
107 views

Has the human body the greatest total length of nerves of all animals?

I've read that a human body contains about 150,000-180,000 km (Pakkenberg et al., 1997; 2003) of nerve wiring in the whole body. But does this length increase with the size of the animal? For example, ...
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13 views

Real unipolar neurons do indeed exist in human?

I studied that the unipolar neuron in human body are not really unipolar but they're pseoudounipolar neurons. On the other hand according to what I understood from wikipedia (neuron) there are real ...
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2answers
55 views

At what age does the mouse skull stop growing?

Unless otherwise mandated, neuroscientific research on mice is done with ~7-week old animals. There is a sort-of mantra that at this age their skulls stop growing. However, recently, I noticed a ...
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3answers
149 views

what is meta-sympathetic nervous system?

I always knew about the sympathetic and para-sympathetic nervous systems, and today I was told about the meta-sympathetic nervous system, but I didn't understand well the man who told me about it and ...
4
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2answers
111 views

Does caffeine actually enhance cognition?

I have heard, respectively: Caffeine measurably enhances cognitive function. Caffeine does not measurably enhance cognitive function in any significant way. Caffeine enhances cognitive function, but ...
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1answer
95 views

Can multiple overt/covert intentions produce identical EEG readings?

With sophisticated techniques likes ERP, it is possible to correlate certain EEG activity with certain overt/covert actions. What I'm wondering is: is there a risk for 2+ overt/covert actions ...
8
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1answer
71 views

Original paper about the all or none law for neurons

I am looking for the original paper about the all or none law for neural activity. I know that there is a very old article about the all or none law for mammalian heart muscle fibers, but I'm ...
6
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1answer
101 views

What determines whether a substance can diffuse across the blood-brain-barrier?

What determines whether a chemical substance is able to cross the blood-brain-barrier via passive, transmembrane diffusion? What structurally differentiates these chemicals?
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34 views

Transcranial Magnetic Stimulation on science fair [closed]

My friends and I would love to make a TMS machine and apply it to make famous "god helmet". We know that magnetic stimulation may cause visions of angels, gods etc. My question is: what are the ...
2
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18 views

Pearson correlation of neural responses with it's linear estimation

I am trying to anderstand the following fact from this article (page 13): How can single neurons predict behavior Suppose I have a linear estimation of a stimulus: $ \hat{s} = \mathbf{w}^T(\mathbf{r} ...
4
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1answer
45 views

How long does a spiking signal last?

It is surprisingly hard to find information about the timing of neurons, in particular how long an action potential can contribute to the summation of a neuron. Is it on the order of milliseconds or ...
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38 views

Why are oral cells (or tissues) more heat resistant? [closed]

When we are having meals, such as enjoying hot pot and drinking hot water, we only have a sense of "warm" in our mouth, or even along the organs in alimentary canal. But when we put our fingers into ...
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2answers
54 views

What is synaptic clearance?

Please explain what the term synaptic clearance means. For example, what would dopamine synaptic clearance be? It is important to me in context of dopamine signaling variation due to difference in ...
3
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1answer
100 views

What is the direction of current flow in myelinated nerve cells?

Is it correct to say electric current flows through the extracellular space, or cytosol of a nerve fiber during impulse conduction? I know that an impulse is actually a change of membrane potential ...
4
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2answers
84 views

How does valerian make you calmer?

Why do Valerian pills make us calmer? What is the mechanism behind it? I understand how artificial tranquilizers work. Do valerian pill have similar chemical components?
3
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1answer
154 views

Can the dendrites of sensory neurons be a meter long?

The typical textbook structure of neurons is a cell with a short dendritic tree and a long axon. The dendrites receive information and send it to the axon via the cell body (soma). The axon is a long ...
2
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1answer
42 views

How are physiological reversal potentials (or ion concentrations) of neurons measured?

Patch clamp electrophysiology experiments typically use an intracellular solution that mimics the ionic concentrations of neuronal cytosol. At the same time, the extracellular solution is meant to ...
3
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2answers
62 views

Why do typical acetylcholinesterase inhibitors (like carbamates) have a greater parasympathetic effect than a sympathetic effect?

I understand that the post-ganglionic neurones of the sympathetic system are adrenergic, but surely these neurones will be excited to the same extent as the parasympathetic post-ganglionic neurones (...
3
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32 views

What is an extinction test?

In Stolerman & Olufsen (2001) I read the sentence: After drug-appropriate responding with the training mixtures reached 85%, generalisation to ethanol was examined in extinction tests. ...
2
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14 views

How do the connections from V1 to V2 form during early development of the human brain?

I am wondering how corticocortical efferents from layer I and II in V1 develop to forward visual information to layer IV in V2. Is there topology preservation in these connections from the beginning ...
2
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1answer
73 views

What's the explanation for those shivers/shudders that happen at random times? [closed]

They happen at any time, presenting as a sudden urge to shiver/shudder all at once. It originates in the neck and shoulders, feels like instant gooosebumps then out of total reflex shoulders roll back ...
3
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1answer
16 views

Is the thecal sac ectoderm?

The thecal sac, or dural sac, is the membranous sheath of dura mater that surrounds the spinal cord and the cauda equina. The thecal sac contains the cerebrospinal fluid in which the spinal cord '...
3
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1answer
26 views

How can dopamine modulate synaptic strength?

Does dopamine act on G protein coupled receptor, leading to more Ca2+ channels on the postsynaptic knob? Also, how is the specificity of the location (of the brain) that dopamine acts on controlled? ...