Tagged Questions
1
vote
1answer
70 views
How exactly does marijuana damage brain cells?
I've heard that THC can cause permanent damage to brain cells. I've also heard this reffered to anti drug propaganda. Another theory i've read is that temporary effects reduce intelligence but long ...
3
votes
1answer
32 views
How does Serotonergic (5-HT2A mediated) Psychedelia work?
How does serotonergic (5-HT2A specific) psychedelia work? I've read that there are some theories that it might involve the induction of a glutamate release in certain regions of the brain involved in ...
3
votes
0answers
42 views
How does the eugeroic modafinil work?
How does the drug, modafinil (Provigil), exert its eugeroic (wakefulness-promoting) effects? I've read that it works by increasing dopamine and histamine concentrations in the CNS and by serving as a ...
3
votes
2answers
155 views
Why is Botulinum toxin the most potent poison known?
Botulinum toxin (trade name Botox) inhibits acetylcholine release in neurons and causes botulism, an acute paralytic disease which leads to nerve degeneration and takes a long time to recover. I've ...
2
votes
0answers
112 views
Are inflammation and anxiety connected?
I've been reading a curious paper about the use of cannabis, and one of the passages piqued my interest:
There’s also been a lot of work done on another constituent of
marijuana, cannabinoid, ...
5
votes
0answers
62 views
Pharmacologically, can tricyclic antidepressants have a side-effect profile similar to neuroleptics?
Torticollis (wryneck, cervical dystonia) is a neurologic movement disorder causing involuntary muscle spasms in the neck. Often, neuroleptics can cause such a side effect. I'm wondering if this ...
3
votes
0answers
68 views
Why do the brains of cocaine-users shrink faster than the brains of non-cocaine users?
http://news.sciencemag.org/sciencenow/2012/04/cocaine-may-age-the-brain.html?rss=1
Cocaine-dependent individuals showed a significantly greater-than-normal age-related decline in gray matter in ...
1
vote
1answer
540 views
How do dopamine agonists like amphetamine/methylphenidate affect acetylcholine signalling?
Do they increase it, or is the effect mostly neutral?
3
votes
0answers
84 views
If D1 receptors stimulate adenylate cyclase (through GPCRs) and D2 receptors inhibit it, then why do mutations in both have similar effects?
D1 and D2 both refer to specific types of dopamine receptors.
I'm sure it has something to do with the fact that the D1 receptors are in regions different from D2 receptors.
I know that adenylate ...
