The study of the structure and function of the nervous system and its components.

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How does a pinched nerve cause pain (at the molecular level)?

Is this due to pressure differentials in the surrounding tissue? (Is it possible to have a pinched nerve without compression of the surrounding tissues, and does this cause pain?) What are the ...
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105 views

Can one dendrite pass through another?

While tracing dendrites on EyeWire I encountered the following situation. They belong to an Orientation Selective Ganglion Cell. It's the first dendrite I've noticed with such a clear 'hole' in it, ...
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191 views

Can rapid eye blinking induce epileptic seizures?

Photosensitive epilepsies are characterized by visually-induced seizures. Flashing-light stimuli are known to induce seizures in some (but not all) patients. My question is whether people with this ...
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126 views

What features cause mechano sensory adaptation?

In relation to mechanoreceptors (e.g. pacinian corpuscles), what stops a constant stimulus from producing action potentials? I understand that adaption is used to filter out stimuli that aren't ...
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200 views

Confused at what is happening with these action potentials

Ok so for a bit of a background, I am doing a science project looking at the action potentials of the earthworm. I anaesthatized the worms then hooked them up to a spiker box (http://backyardbrains....
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2k views

How do neurons form new connections in brain plasticity?

I've been reading about brain plasticity and how the brain can "rewire" itself. One of the things that is not clear to me - how neurons can establish new connections. Does this rewiring mean that ...
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280 views

Why is the Patellar reflex not triggered when the tendon is extended slowly?

I have been previously told that the Patellar reflex (knee-jerk-reaction) exists to prevent the hyper-extension of the patellar tendon. Yet if the impact to the tendon is delivered slowly - i.e. by ...
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286 views

At what point during an action potential are the sodium potassium pumps working?

I'm trying to understand how all of the potentials during an action potential are created. My question specifically is about the sodium potassium pumps, however I would also be grateful if someone ...
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352 views

Can a single axon propagate multiple simultaneous action potentials?

I have not been able to locate any research that indicates whether a single axon of a neuron or nerve cell can conduct multiple simultaneous (i.e. spatially separate) action potentials. I am aware ...
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114 views

The mechanism of mechanoreception?

I am interested in knowing the molecular mechanism behind mechanoreception/mechanotransduction (i.e. mechanism behind receptor potential generation on mechanical stimulation). I know that most ...
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7k views

What are the advantages and disadvantages of being ambidextrous?

Most of us have one dominant hand. We find it nigh on impossible to do very delicate or dextrous activities with our other-hand. This seems like an apparent weakness, and a rather odd one when you ...
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172 views

Do adjacent axons in a nerve influence each other?

Suppose I have a nerve fiber consisting of several axons all running in parallel to each other. When an action potential is generated in a certain axon, this will alter the concentration of sodium ...
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402 views

Refractory period in action potential

I know that the part E in this graph is definitely the part of refractory period. My question : Will there be any effect on B,C or D if a stimulus is given at time B,CorD respectively ?
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364 views

How does a neuron change as you learn?

I am currently taking a course called "Introduction to Machine Learning with ENCOG 3", and I have a question about how well the Artificial Intelligence (AI) algorithm for a "neural network" ...
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186 views

Is there a biological neuron that spikes in response to hyperpolarizing currents?

As some background I've been building Electrophysiological models of neurons, and in the process stumbled upon a model, that in all respects is biologically plausible, but has a bizarre property I ...
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115 views

What were the first neural systems like?

I'm curious about the origin of the neural network. I'm thinking perhaps once life evolved beyond the single cell organism, it needed a simple neural network to coordinate those cells, and cell ...
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308 views

What keeps the resting potential of neurons constant at -70 mV?

I know the sodium-potassium pump pumps out 3 Na+ ions and pumps in 2 K+ ions per reaction so the negative charge in the axon increases. However, once the voltage (difference of charge inside and ...
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501 views

What causes Paresthesia (Pins and Needles) at a cellular level?

I've looked it up in plenty of places like the Wikipedia page and such, and it is clear that the most common cause of Paresthesia is either a fair amount of pressure on a specific patch of skin ...
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285 views

What is the limit of time resolution in fMRI?

I was reading about a few studies on estimating functional connectivity between brain areas using fMRI signals. However, as far as I know that fMRI has a very poor time resolution, roughly in the ...
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392 views

Are cerebellar basket and stellate neurons actually different cell types?

The title more or less says it all, but to contextualise a bit: Cerebellar molecular layer interneurons have been classified, probably since Cajal, into the basket cells, which synapse onto the soma ...
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73 views

What stimulates a nociceptor?

For instance, when pressure is applied to the skin, what determines how much pressure results in nociceptor stimulation. And when a sharp object pierces the skin, why is pain, rather than simply touch,...
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111 views

Neuronal coordinates of C.elegans

Is there a list of neural coordinates for C.elegans? I need it to build a 3D model. Update: What is available at the moment is: full connectome for example, at openconnectome; neuron description ...
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55 views

Behavioral change in dolphins during different hemispheres activity periods?

It is known that dolphins never sleep in the sense that we do, instead they have one hemisphere of the brain sleeping while the other one is awake. I wonder, do they show observable changes in ...
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620 views

Is the six-layer cortex model of the mammalian cortex still the most accepted model?

I've been reading a bit about the different layers of the cerebral cortex and its clear that certainly not every region of the cortex has the same number of layers. Thus, the idea that every region ...
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183 views

Why did the Brain develop in the front in most organisms?

I was wondering: why most, well, pretty much all organism with a brain have it right in front of their bodies or at the top.
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474 views

Why is membrane potential not zero at equilibrium?

For the squid giant axon, the membrane potential computed by the Goldman equation is -60mV. And the Nernst potentials are (the differences between the K+ and the Na+'s Nernst potential and the ...
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175 views

Pharmacologically, can tricyclic antidepressants have a side-effect profile similar to neuroleptics?

Torticollis (wryneck, cervical dystonia) is a neurologic movement disorder causing involuntary muscle spasms in the neck. Often, neuroleptics can cause such a side effect. I'm wondering if this ...
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95 views

If a non-mammal is starved of oxygen for some time, how long would it take the animal's neurons to die?

This is a follow-up question to Why do neurons die so quickly (relative to other cells) when deprived of oxygen?. I'm particularly interested in the case of reptiles, octopuses, and other ...
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71 views

How do neurons find each other?

Neurons form complicated networks in brains, but their connections can't be random (at least not entirely). Brains function similarly among all members of individual species, and that functionality is ...
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183 views

Disproportion in cranial nerve innervation?

The cranial nerve innervation is highly disproportionate, as far as humans are concerned. I am not sure of the advantage of being innervated by cranial nerve versus being innervated by a normal ...
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What causes the range of severity of neurological deficits in Down's syndrome?

It's known that the severity of symptoms caused by a trisomy 21 varies from individual to individual. Part of the explanation for this range of severity is the finding that 94% of Down's syndrome ...
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760 views

Does a neuron ever generate an action potential without stimuli?

Most accounts I read involving action potentials and synapses and the like tend to focus mostly on the action potential as a mere automatic reaction to another similar event happening upstream. From ...
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234 views

Is brain transplantation possible?

Many organs can be transplanted nowadays, including the liver, lungs and kidneys. Can the brain be transplanted?
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915 views

Is there a biological basis to physical attraction?

Is there something encoded within us that makes us attracted to, e.g., someone taller or shorter with blonde or brunette hair with green or blue eyes? Or, is this phenomenon completely based on ...
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540 views

Relationship between nerves and axons

I just wanted to get a realistic viewpoint of our nervous system. I understand arteries and veins, but I wanted to know how similar our nervous system is to that? I understand we have neurons (...
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Why do neurons die so fast without oxygen and nutrients?

Some human tissue can survive without oxygen a couple of minutes, even hours. Why are the neurons are so "weak" and depends so much on oxygen and other nutrients and cannot live without them for ...
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541 views

Is it purely the nervous system causing vaginal lubrication (arousal)?

My girlfriend was watching some documentary on TLC about a paralyzed woman getting pregnant. I believe that woman still has some feeling, as she spoke about feeling the effects of a bladder ...
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2k views

Why can action potentials not be initiated at dendrites?

Why are action potentials not initiated at dendrites, although dendrites are the first to receive input from the presynaptic cell? In fact, excitatory postsynaptic potentials (EPSPs) at the dendrites ...
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4k views

Are sensory receptors neurons?

Background There are many receptor types in the body, with various functions and various mechanisms of transduction. Receptor cells are considered to be part of the peripheral nervous system, as they ...
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Cat purring: What are some possible underlying mechanisms behind purring and bone remodeling and formation?

http://www.scientificamerican.com/article.cfm?id=why-do-cats-purr The article above says that cats purr mostly when they're wounded or under duress. They hypothesis that cats purring leads to ...
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273 views

Understanding Membrane / Resting Potential from the perspective of ions?

From wikipedia article RESTING potential: "there is no actual measurable charge excess in either side. That occurs because the effect of charge on electrochemical potential is hugely greater than the ...
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Density of neurons/cells in the mouse brain

Could someone point out some relevant papers or resources (an online DB maybe?) describing the density of neurons (or, more in general, of cells) in different areas of the mouse brain?
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135 views

What recovers normal polarisation after hyperpolarisation?

I have been taught that a Na+/K+ pump helps to recover normal polarisation after hyperpolarisation in neurons. I could not find out how it does that, since I've also been taught that such a pump moves ...
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136 views

Hebbian theory “fire together” clarification

Donald Hebb states it as follows: "Let us assume that the persistence or repetition of a reverberatory activity (or "trace") tends to induce lasting cellular changes that add to its stability.… ...
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286 views

Task-dependent “reversed” handedness: why use left hand for some tasks? How is it controlled by the brain?

I am right-handed. Which means that when I hammer down a nail, I hold the nail in my left hand, with which I can hold it straight and at a controlled position. This is true in situations where the ...
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228 views

Dopamine paradox in schizophrenia

If there is more dopamine action in the mesocortical pathway in schizophrenia, then schizophrenics should always be in euphoric state. Instead, schizophrenics often lack motivation and do not ...
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190 views

Brain + ethanol experiment suggestions needed

I need to demonstrate the effects of ethanol on a human brain (or other brain with developed telencephalon) in vitro; ideally the effects on vigilance and/or memory. Could you please suggest such an ...
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375 views

First discovery of long-term depression?

LTP was first described by Tim Bliss and Terje Lømo in their paper Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the ...
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122 views

Latency to audition in human beings?

On average, in a human being with no neurological deficits, how long does it take for a sound which is sensed in the ear to reach the cortex? Which brainstem structures are most responsible for the ...
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113 views

What determines whether a substance can diffuse across the blood-brain-barrier?

What determines whether a chemical substance is able to cross the blood-brain-barrier via passive, transmembrane diffusion? What structurally differentiates these chemicals?