The study of the structure and function of the nervous system and its components.

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276 views

Ventral stream pathway and architecture proposed by Poggio's group

Please can you give me a very brief explanation about all functions in the ventral stream architecture summarized in this figure: This figure is from Serre et al.'s A quantitative theory of ...
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58 views

Number of MHCs in neurons

I have read that neurons have proportionately less MHC molecules than other cells of the body. What is the advantage of this?
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98 views

Do voltage-gated calcium channels affect neuronal conduction speeds?

We have a hypothesis that a drug may block the voltage-gated calcium channels (VGCC) in annelid worms. We are wondering whether there are any correlations between VGCCs and neuron conduction ...
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946 views

Optogenetics - How do microbial opsins work?

I'm just introduced to the optogenetics method and am having some trouble grasping the genetics (of the optogenteics) part of things. So we have Retinal and Opsin that form Rhodopsin molecule that ...
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194 views

How do axon terminals report to the soma?

It is important to bear in mind that the distance between a neuron's axon terminal and its soma can be extensive, up to about 1m in the human body. The fastest transport along the axon is 400mm/day ...
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2k views

Is “tonic activity” common for neurons firing in the brain?

I've been reading about Dorsal Raphe Nucleus, a serotonin- rich part of the brain. I noticed mentioning of "tonic activity" - regular pulsing that releases neurotransmitters. On top of this "tone" the ...
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456 views

How is propagation of action potentials terminated once the “message” has been sent/received?

I'm thinking about neurons in the brain that are used for "thinking". As I read about action potentials, I see that an Axon is connected to a Dendrite of a neighboring cell and that there are ...
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81 views

Text/resource with information on all skeletal muscles and their motor units

Something analogous to an encyclopedia on baseball players with a list of all thier stats would be ideal. I'm not looking for just generic muscle names, locations and illustrations. Good answers ...
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2answers
432 views

Does body mass have a bearing on reflex speed?

A reflex is an unconscious action in response to some specific stimulus, e.g., blinking an eye, or pulling the hand away from a hot pin I know from school biology, and reading online that withdrawal ...
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34 views

How are individual neuron firing rates characterized?

I'm reading this paper that the Human Brain Project published in Cell and I'm confused how they recorded the firing rates shown in the firing below: In the publication, they mention that they use ...
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27 views

Does the number of nodes determines the rate at which a neural signal is transmitted?

I know that the the bigger the neuron's diameter is, the faster the neuron signal is transmitted. This makes sense according to the proportionality of resistance to the inverse of area and thus, in ...
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207 views

What keeps the resting potential of neurons constant at -70 mV?

I know the sodium-potassium pump pumps out 3 Na+ ions and pumps in 2 K+ ions per reaction so the negative charge in the axon increases. However, once the voltage (difference of charge inside and ...
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48 views

Can a postsynaptic neuron 'shut itself off?

I am an amateur interested in neuroscience and was curious whether there is a process by which a neuron or group of neurons would close their receptors and stop receiving signals from specific ...
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157 views

dopamine paradox in Schizophrenia

If there is more dopamine action in the mesocortical pathway in Schizophrenia, then the patients should always be in euphoric state. But instead patient lacks motivation and don't want pleasure. Why?
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2k views

What happens in your brain when you receive information which causes you to bristle?

I'm talking about moments when you watch a film and you bristle, or when you listen to music, etc. What kind of neurotransmitter flow changes?
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212 views

Hearing and neurons- do ears have a sampling period?

From what I have read, outer hair cells in the human ear amplify incoming signals and inner hair cells "pick-up" the signals and generate action potential. However, neurons have refractory periods ...
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160 views

Which Receptors are Involved in the antidepressant effects of SSRIs?

From what I've read the major receptor subtypes involved in the antidepressant effects of SSRIs are: 5-HT1A 5-HT2C 5-HT3 5-HT6 Please cite journal articles to back up your claims, I don't want any ...
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1k views

Physiological indicators of happiness and well being

If I understand it correctly, levels of serotonin in the brain can indicate if a person is happy. What other physiological measures indicate happiness or well being for a humans? I am looking for ...
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2answers
285 views

Does the speed of electrical impulses through neurones decrease with age?

From what I read on the NatGeo app, it stated that the speed of the electrical impulses that are sent by a neurone will be approximately 332 kilometers per hour. Will the speed of this electrical ...
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20 views

How are targets formed for axon growth cones (CNS)?

Axons have growth cones which find a route to their target using multiple methods (guidepost cells, attraction to target, etc...). My question is, what is the process that actually forms the target? ...
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70 views

Neural coupling between Pinsky-Rinzel (reduced Traub) neuron with a Wang-Buzsaki neuron?

I have read two papers related to modeling neurons. The first one is the paper by Pinsky and Rinzel and the second one by Wang and Buzsaki. The first mentioned neuron model is a excitatory neuron ...
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74 views

How we share pain?

When somebody else tells me about his or her itching or pain in some specific body part I sometimes begin to feel similar feelings. I can think of about three explanations: I feel pain all over my ...
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1answer
50 views

Cross section of actin network in neurites

for a simulation I am developing I would like to know how the actin network in neurites is distributed. Is actin confined to the periphery or is the whole neurite shaft containing actin with a rather ...
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55 views

The use of proteins in memory creation

I have very limited knowledge of how the human memory works as I think, at this time, most people do. However, I have been reading and some articles which say, and I quote the article just linked ...
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95 views

What is the energy consumption of the brain?

What is the energy consumption of the brain, and is there a difference in consumption when waking and sleeping?
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65 views

The Operation of tuning in the S1 layer of ventral model

According to my previous question in ventral Stream pathway and architecture, I want now to get a brief example about how the S1 layer is constructed. In other words, how all the simple units are ...
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3answers
663 views

Can human brain memory be removed by EMP?

The human brain is the most complicated human organ so it is hard to examine it completely but based on what we know do you think (or do you know from some source) if a human memory can be removed by ...
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269 views

Can connections between neurons be weakened?

Connections between neurons are said (by Wikipedia) to be strengthened as part of learning - can they also be weakened (below the original level)? I understand the concept of the connections ...
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2k views

What is in the space between neurons in a brain?

When neuron animations are displayed, there are frequently seen neurons, axons arranged in a lattice with a lot of empty space between. I'm interested if there is indeed empty space in the brain, or ...
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132 views

Parallels between pixelized image and the human retina

On Wikipedia it is explained that the human eye has a certain 'resolution'. Does this mean that the retinal image consists of pixels? If yes, what shape would these pixels have?
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39 views

What Role Antagonists Play in the Study of Drugs?

I am pretty unfamiliar to pharmacology. I'm doing a research on drug abuse, particularly opioids' mechanism of action. I encountered several times evidences that come from studies using antagonists ...
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803 views

Is there such thing as “half-life” of dopamine?

If a dopamine is released at T=0 and binds to receptor D2, what determines the time when the concentration of this neurotransmitter bound to the receptor reaches half of the original concentration? In ...
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108 views

Book recommended for neurobiology

I am looking for a good explanatory book concerning Neurobiology. I am interested on how the brain works but prior to this I believe that I have to start learning things about the biology of neurons. ...
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60 views

Why doesn't the ambient lighting condition change the perception of colors we see on a monitor?

Suppose that I take a picture of an object illuminated by an incandescent light bulb and I choose the daylight white balance setting. The picture I then get will display a white object as looking ...
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221 views

How do neurons inverse an action potential?

See the following figure (source): The pathway on the right (SN $\rightarrow$ interneuron $\rightarrow$ F Neuron $ \rightarrow $ flexor muscle), is explained as follows: The action potential in ...
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68 views

Are antihistamines considered to be psychoactive substances?

I have heard many times that the widely used antihistamines are not considered to be psychoactive drugs. Yet their impact on ones cognitive functions can be substantial. According to some sources, ...
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250 views

Why does chewing enrage me?

Whether it's snacking on chips, munching on salad, or simply chewing gum, when I hear someone do it within an earshot, it drives me completely bonkers! It doesn't matter if it's my girlfriend, my ...
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145 views

Resting and action membrane potential..?

In the resting membrane potential of neurons the inside of membrane is kept negative and outside of membrane is kept positive by the utilization of energy through Na-K Atpase pump, While during action ...
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116 views

What will happen if we expose the brain to an intermittent light?

If a brain is exposed to an intermittent light are specific areas going to fire? If yes, which of them? Is there any experiment about this?
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1k views

What is 'calcium conductance'?

What is the meaning of calcium conductance in ion channels. I encountered this in the following text: It was established that the µ and δ opioid receptors open potassium channels, which results ...
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2k views

What is a cortical circuit?

I have read about cortical circuits in the context of connectomics (e.g. any example here) and computational neuroscience (e.g. any example here), but a simple Google/Wikipedia does search not show an ...
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64 views

Reseach on feeling pain of other people

I'm more of a tech than bio kind of guy, but I have read and learned a lot alongside of my girlfriend's education. Which is very interesting!! Currently I want to investigate : people claiming to ...
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1answer
47 views

I know how to solve these equations, but I'm not sure what t' represents?

I am investigating the Wilson Cowan neuron population model, and I can follow most of it, but I'm not sure what is meant by t' in the equation for proportion of neurons in the refractory period. The ...
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106 views

What would be required to evolve an animal (non-human) brain to obtain human-level cognition? [closed]

Could any animal subject to the right conditions evolve human-level intelligence? Suppose that an artificial intelligence (AI) decided to artificially evolve a population of octopus (don't ask why, ...
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1answer
836 views

What percent of the population has some form of synesthesia?

Data I am trying to get my hands on: What types of synesthesia (e.g. Grapheme-color synesthesia, Chromesthesia, etc.) are most common across the population? What percent of population has that ...
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1answer
39 views

Confusion over role of current/potential in Nervous system?

I am taking a course on the nervous system and I am do not have any physics background. Therefore, I would like to know, what are we precisely talking about when we talk about current in the nervous ...
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567 views

Do ants feel pain?

I have watched video on youtube where guy pours molten aluminium into fire ant colony to make casing. In the comments below there's huge discussion on is that a right thing to do. I am on the side ...
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545 views

What is the difference between clinical and non-clinical depression, and is there a term for different severity of the bipolar disorder?

I was looking for a term which describes a bipolar disorder of lesser severity. I know from experience from someone I know well, what a very severe case of the bipolar disorder looks like, when an ...
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1answer
62 views

Measurement of glucose concentration in the human brain

If I want to measure the exact glucose concentration in a human brain then how can I proceed to do that? Is there any technique or assay to do that?
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1answer
158 views

Why do the neuron pathways decussate?

I learn about the brain right now, and there are crossing of neuron pathways everywhere; in the thalamus, the medulla oblongata, the pyramidal tract... And I don't understand why? What is the reason ...