The study of the structure and function of the nervous system and its components.

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Can 'hardware' thermalization explain memory decay?

Often we are able to memorize very precise bits of information (exact addresses, birthdays of inlaws, number of dirty socks under the bed), but over time our recollection tends to become fuzzy. We no ...
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1answer
58 views

Refractory period in action potential

I know that the part E in this graph is definitely the part of refractory period. My question : Will there be any effect on B,C or D if a stimulus is given at time B,CorD respectively ?
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68 views

The mechanism of mechanoreception?

I am interested in knowing the molecular mechanism behind mechanoreception/mechanotransduction (i.e. mechanism behind receptor potential generation on mechanical stimulation). I know that most ...
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1answer
49 views

Do skull bones have pain nerves (nociceptors)?

I recently attended an awake brain surgery for deep brain stimulation and it seemed to me that only the skin surrounding the drilled hole got local anaesthesia. I know that the brain itself does not ...
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1answer
53 views

What happens during a Raynauds episode?

Raynaud's phenomenon can be a serious health issue, as the blood flow to the extremities, mainly the fingers is compromised, causing fingers to blanche, and then turn blue. Severe Raynaud's can cause ...
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1answer
26 views

Is there a correlation between total neurons and intelligence?

Thanks for looking. First off, I am not a biologist, just a curious layman, so I apologize in advance if this isn't a "good" question. Please don't downvote me into oblivion. I read today that the ...
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112 views

How reversible is DAT upregulation from long-term ADHD medication use?

A mechanism for ADHD stimulant medication tolerance has now been found. See http://neurosciencenews.com/adhd-medication-patient-brains-adapt-dat/. Here's the thing though: what exactly is the ...
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72 views

Neuroendocrinal mechanism of parturition

My book reads, "The fetus signals that it is mature by secreting certain hormones that diffuse across the placenta into mother's blood and cause the secretion of oxytocin from her posterior ...
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0answers
20 views

How does Sodium Valproate cause neural plasticity

I have been reading a fascinating paper: Valproate reopens critical-period learning of absolute pitch 18 individuals were given Sodium Valproate (VPA) for a fortnight during which they trained on a ...
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105 views

If D1 receptors stimulate adenylate cyclase (through GPCRs) and D2 receptors inhibit it, then why do mutations in both have similar effects?

D1 and D2 both refer to specific types of dopamine receptors. I'm sure it has something to do with the fact that the D1 receptors are in regions different from D2 receptors. I know that adenylate ...
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0answers
19 views

Cross section of actin network in neurites

for a simulation I am developing I would like to know how the actin network in neurites is distributed. Is actin confined to the periphery or is the whole neurite shaft containing actin with a rather ...
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0answers
106 views

How is membrane capacitance related to the increased speed of saltatory conduction?

Here is the original question which inspired my question below. As explained by the answers there, the reason saltatory conduction in myelinated neurons is faster than non-myelinated conduction is ...
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57 views

The Operation of tuning in the S1 layer of ventral model

According to my previous question in ventral Stream pathway and architecture, I want now to get a brief example about how the S1 layer is constructed. In other words, how all the simple units are ...
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0answers
60 views

What is the limit of time resolution in fMRI?

I was reading about a few studies on estimating functional connectivity between brain areas using fMRI signals. However, as far as I know that fMRI has a very poor time resolution, roughly in the ...
3
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0answers
220 views

How does the eugeroic modafinil work?

How does the drug, modafinil (Provigil), exert its eugeroic (wakefulness-promoting) effects? I've read that it works by increasing dopamine and histamine concentrations in the CNS and by serving as a ...
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0answers
34 views

Inductance in cell

In an animal cell, especially neuron and in particular its axon, while there is electrical resistance and capacitance mechanism in the cell, which play essential roles in the cable theory model of ...
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0answers
35 views

Are there baby drinks closer to breast-milk?

Many women cannot or will not feed their children with breast-milk. It is my understanding breast-milk has many advantages over formula. Some psychological like oxytocin and some physiological like ...
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0answers
106 views

Saltatory Conduction Of Nerve Impulses

I am aware about some basics of Saltatory conduction of nerve impulses. I know that the nerve impulses(ionic flow and the depolarization) are transferred from the node to the node in myelinated nerve ...
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0answers
20 views

What features cause mechano sensory adaptation?

In relation to mechanoreceptors (e.g. pacinian corpuscles), what stops a constant stimulus from producing action potentials? I understand that adaption is used to filter out stimuli that aren't ...
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0answers
41 views

Nocioception (pain perception) in subcutaneous tissue

There seem to be no nocioceptors (pain and temperature sensitive nerve endings) in subcutaneous fat. there are nocioceptors and other receptors in veins running through fat, but these can be avoided. ...
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0answers
41 views

Do voltage-gated calcium channels in earthworms relate to speed of neuron conduction?

We have a hypothesis that a drug may block the voltage-gated calcium channels (VGCC) in annelid worms. We are wondering whether there are any correlations between VGCCs and neuron conduction ...
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0answers
78 views

How long does Lentivirus take to express in vivo mouse neurons?

Does anyone know how long it takes for a standard Lentivirus vector to express its genes (under a strong promoter such as CAG, CB7, etc.), after injection into the brain of a mouse? By hearsay I ...
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0answers
205 views

Why do antidepressants have a delayed onset of action?

Why do antidepressants take so long to reach efficacy? I've read of theories about it perhaps being due to the strength of negative feedback via serotonergic and adrenergic autoreceptors during the ...
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0answers
90 views

In scuba diving, are nitrogen narcosis and high pressure nervous syndrome the same thing?

In training for scuba diving, they tell you that when you're bellow 100 ft or so you have to watch out for changes in mental state that resemble drunkenness. The cause of these mental disturbances is ...
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26 views

Kinesin-5 / cytoplasmic dynein spatial density distribution in neurons

is there some way to experimentally determine the density distribution of those two molecular motors in a Neuron? Fluorescence labeling would be impossible(?) as GFP markers would probably alter the ...
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0answers
59 views

In-Ear headphones increasing nasal breathing resistance

I figure this is a rather strange question, however, I noticed this quite some time ago and wanted to make sure that this is in fact a permanent condition before posting. The situation is as follows: ...
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23 views

Neuroscience: zapping an axon connected to thermoreceptor

Let’s say an experimenter has an electrode that can give a shock to a single axon. She takes that electrode and zaps an axon connected to thermoreceptors in the hand of her subject. I) What would the ...
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25 views

Systematic anticoagulant injection after a CVA

Since most of the cerebrovascular accident are ischemic ones, would it be usefull to have anticoagulant everywhere (we already have AEDs everywhere) so that everytime someone would have symptoms of a ...
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0answers
32 views

Alpha wave frequency variance in EEG of single subject over period of a few hours?

I have an Emotiv EPOC (EEG headset: 128 SPS, notch filter @60 Hz, felt saline contacts) I've been playing around with. Over the course of two or three hours using CCA to plot an SNR contour against ...
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0answers
66 views

Why are there different types of neurotransmitters?

Why does the type of neurotransmitter matter? If the neurotransmitter just stimulates a dendrite on a neuron which causes electricity to move through via sodium-pottasium pumps and ion gates to ...
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42 views

Does pain scale with mammal mass?

Some biological features scale with the animal mass (see previous Q&A). Assuming the same concentration of nociceptors on the skin surface, I'm wondering how painful a 1 cm wound will be ...
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122 views

Does brain activity generate heat gradients in the brain?

I'm reading this article on guiding axon growth using temperature gradient, and it mentions that the trajectory of growth of neuron connections can be influenced by temperature gradients as little as ...
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0answers
35 views

Hippocampal regulation of hypothalamus

What is the difference between CA1-CA4 hippocampal subfields and dentate gyrus (DG) in negative regulation of hypothalamus? I`ve found only evidence that GR expression is more in CA1-2 and DG, while ...
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164 views

Does sexual arousal inhibit functions of prefrontal cortex in human females as well as males?

I've read somewhere, that when a human male experiences sexual arousal, his prefrontal cortex and, hence, his ability to reason and make rational decisions, is being heavily inhibited. Sounds pretty ...
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59 views

Carrying or packaging capacity of SAD B19 dG rabies virus

I'm wondering about the carrying capacity also referred to packaging capacity or loading capacity (how many base pairs can be packed efficiently into virions) of the pseudotyped rabies virus SAD-dG as ...
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19 views

Which Receptors are involved in Psychedelia/Psychosis?

Which receptors are involved in Psychedelia/Psychosis? I know that the 5-HT2A, 5-HT3, D2, κ-opioid and NMDA receptors are likely involved in psychosis.
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49 views

The relationship between the currents of intracellular and extracellular ions of a cell

In a cell, assume that only sodium, potassium, chloride and calcium ions can cross the membrane and their currents are: $I_{Na}$, $I_{K}$, $I_{Cl}$ and $I_{Ca}$, across the whole membrane. There is ...
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0answers
50 views

Does Dorsal Raphe Nuclei firing pattern change in response to voluntary breathing?

I'm reading this paper, which discusses how Serotonin may be involved in motor functions of mammals: 5-HT and motor control: a hypothesis . The paper includes the following diagram of the Dorsal ...
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How do two bodies synchronize chemical reactions ?

I understand that some biologists have a very materialistic view of life, in the sense that everything that a living does is a result of certain chemical reactions, if that was the case then when i ...
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24 views

Spinal cord injury bypass

When the spinal cord is damaged, the connection between the brain and some part of the body may be lost. To restore this connection, some research are carried out, with mainly two different goals : ...
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20 views

spinal cord lesion and result in somatic sensation

Jimbo suffers a lesion to the entire right half of the spinal cord at the T6 level. A few weeks after his injury, his doctor tests his right and left legs for somatic sensation and tone. fill out her ...
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31 views

What percentage of possible proteins has been tested by human brain evolution?

When the human human brain is discussed, I frequently hear an argument that goes like this "If there was a simple chemical solution for people to be smarter, nature would've already found it". I'm ...
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105 views

The process of how you visually perceive objects?

Use the following terms to describe in detail how you visually perceive an object that you can see right now. Use the terms in order to correctly describe the sequence of events involved in your ...
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21 views

Stress regulation in mosquitoes

I was just trying to understand how in insects, specifically mosquitoes does the process of emergency responding, stress regulation take place? Or in simpler words how are flight, fright and fight ...