The study of the structure and function of the nervous system and its components.

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Can 'hardware' thermalization explain memory decay?

Often we are able to memorize very precise bits of information (exact addresses, birthdays of inlaws, number of dirty socks under the bed), but over time our recollection tends to become fuzzy. We no ...
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1answer
56 views

Disproportion in cranial nerve innervation?

The cranial nerve innervation is highly disproportionate, as far as humans are concerned. I am not sure of the advantage of being innervated by cranial nerve versus being innervated by a normal ...
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1answer
50 views

What is the current consensus, if any, about why long term potentiation is not clearly correlated with learning?

I was watching a video where a professor said that according to some experiments, Long Term Potentiation (LTP) is correlated with better learning, while in yet other experiments, LTP is correlated ...
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1answer
67 views

dopamine paradox in Schizophrenia

If there is more dopamine action in the mesocortical pathway in Schizophrenia, then the patients should always be in euphoric state. But instead patient lacks motivation and don't want pleasure. Why?
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1answer
29 views

Solubility of Forskolin in ethanol

I am interested in using forskolin in cell culture medium. Does anyone know how to make solution of 10 microM forskolin in 5% ethanol or less. I would like to avoid using DMSO as a solvent. Thank you. ...
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1answer
38 views

Does neuroeconomics study the brain or study economics?

I'm trying to understand what neuroeconomics is. There are two possibilities for what it might mean. (1) The study of cognitive processes in the brain by applying basic principles of economic theory ...
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1answer
66 views

Text/resource with information on all skeletal muscles and their motor units

Something analogous to an encyclopedia on baseball players with a list of all thier stats would be ideal. I'm not looking for just generic muscle names, locations and illustrations. Good answers ...
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1answer
17 views

Neuroscience:Spinal tract

I have few confusions finding the answer for the questions below. I have tried answering the first two But i am not sure if it is right or not? And i do not know about the third one? 1.in which ...
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1answer
48 views

M-type potassium channels by muscarinic receptors

How does the closure of M-type potassium channels by muscarinic receptors result in increased excitation of the target neuron?
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103 views

How reversible is DAT upregulation from long-term ADHD medication use?

A mechanism for ADHD stimulant medication tolerance has now been found. See http://neurosciencenews.com/adhd-medication-patient-brains-adapt-dat/. Here's the thing though: what exactly is the ...
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62 views

Neuroendocrinal mechanism of parturition

My book reads, "The fetus signals that it is mature by secreting certain hormones that diffuse across the placenta into mother's blood and cause the secretion of oxytocin from her posterior ...
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0answers
98 views

Pharmacologically, can tricyclic antidepressants have a side-effect profile similar to neuroleptics?

Torticollis (wryneck, cervical dystonia) is a neurologic movement disorder causing involuntary muscle spasms in the neck. Often, neuroleptics can cause such a side effect. I'm wondering if this ...
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103 views

If D1 receptors stimulate adenylate cyclase (through GPCRs) and D2 receptors inhibit it, then why do mutations in both have similar effects?

D1 and D2 both refer to specific types of dopamine receptors. I'm sure it has something to do with the fact that the D1 receptors are in regions different from D2 receptors. I know that adenylate ...
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0answers
82 views

How is membrane capacitance related to the increased speed of saltatory conduction?

Here is the original question which inspired my question below. As explained by the answers there, the reason saltatory conduction in myelinated neurons is faster than non-myelinated conduction is ...
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0answers
57 views

The Operation of tuning in the S1 layer of ventral model

According to my previous question in ventral Stream pathway and architecture, I want now to get a brief example about how the S1 layer is constructed. In other words, how all the simple units are ...
3
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0answers
57 views

What is the limit of time resolution in fMRI?

I was reading about a few studies on estimating functional connectivity between brain areas using fMRI signals. However, as far as I know that fMRI has a very poor time resolution, roughly in the ...
3
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0answers
196 views

How does the eugeroic modafinil work?

How does the drug, modafinil (Provigil), exert its eugeroic (wakefulness-promoting) effects? I've read that it works by increasing dopamine and histamine concentrations in the CNS and by serving as a ...
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0answers
32 views

Are there baby drinks closer to breast-milk?

Many women cannot or will not feed their children with breast-milk. It is my understanding breast-milk has many advantages over formula. Some psychological like oxytocin and some physiological like ...
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0answers
40 views

Refractory period in action potential

I know that the part E in this graph is definitely the part of refractory period. My question : Will there be any effect on B,C or D if a stimulus is given at time B,CorD respectively ?
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0answers
78 views

Saltatory Conduction Of Nerve Impulses

I am aware about some basics of Saltatory conduction of nerve impulses. I know that the nerve impulses(ionic flow and the depolarization) are transferred from the node to the node in myelinated nerve ...
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0answers
19 views

What features cause mechano sensory adaptation?

In relation to mechanoreceptors (e.g. pacinian corpuscles), what stops a constant stimulus from producing action potentials? I understand that adaption is used to filter out stimuli that aren't ...
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0answers
57 views

The mechanism of mechanoreception?

I am interested in knowing the molecular mechanism behind mechanoreception/mechanotransduction (i.e. mechanism behind receptor potential generation on mechanical stimulation). I know that most ...
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0answers
187 views

What are the advantages and disadvantages of being ambidextrous?

What are the advantages and disadvantages of being ambidextrous? We have two hands and we nearly can't use one and this seems like a weakness, and a stupid one when you first think about it. But ...
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37 views

Nocioception (pain perception) in subcutaneous tissue

There seem to be no nocioceptors (pain and temperature sensitive nerve endings) in subcutaneous fat. there are nocioceptors and other receptors in veins running through fat, but these can be avoided. ...
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0answers
40 views

Do voltage-gated calcium channels in earthworms relate to speed of neuron conduction?

We have a hypothesis that a drug may block the voltage-gated calcium channels (VGCC) in annelid worms. We are wondering whether there are any correlations between VGCCs and neuron conduction ...
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0answers
72 views

How long does Lentivirus take to express in vivo mouse neurons?

Does anyone know how long it takes for a standard Lentivirus vector to express its genes (under a strong promoter such as CAG, CB7, etc.), after injection into the brain of a mouse? By hearsay I ...
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0answers
165 views

Why do antidepressants have a delayed onset of action?

Why do antidepressants take so long to reach efficacy? I've read of theories about it perhaps being due to the strength of negative feedback via serotonergic and adrenergic autoreceptors during the ...
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0answers
87 views

In scuba diving, are nitrogen narcosis and high pressure nervous syndrome the same thing?

In training for scuba diving, they tell you that when you're bellow 100 ft or so you have to watch out for changes in mental state that resemble drunkenness. The cause of these mental disturbances is ...
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18 views

Neuroscience: zapping an axon connected to thermoreceptor

Let’s say an experimenter has an electrode that can give a shock to a single axon. She takes that electrode and zaps an axon connected to thermoreceptors in the hand of her subject. I) What would the ...
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0answers
24 views

Systematic anticoagulant injection after a CVA

Since most of the cerebrovascular accident are ischemic ones, would it be usefull to have anticoagulant everywhere (we already have AEDs everywhere) so that everytime someone would have symptoms of a ...
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0answers
25 views

Alpha wave frequency variance in EEG of single subject over period of a few hours?

I have an Emotiv EPOC (EEG headset: 128 SPS, notch filter @60 Hz, felt saline contacts) I've been playing around with. Over the course of two or three hours using CCA to plot an SNR contour against ...
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0answers
57 views

Why are there different types of neurotransmitters?

Why does the type of neurotransmitter matter? If the neurotransmitter just stimulates a dendrite on a neuron which causes electricity to move through via sodium-pottasium pumps and ion gates to ...
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0answers
29 views

What happens during a Raynauds episode?

Raynaud's phenomenon can be a serious health issue, as the blood flow to the extremities, mainly the fingers is compromised, causing fingers to blanche, and then turn blue. Severe Raynaud's can cause ...
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71 views

Learning first-year biology + anatomy via documentary?

Probably going to take first-year biology in ~4 months; so was thinking to go through MIT's 7.00x on EdX… However seeing at how popular this topic is, I was thinking there might be a fun documentary ...
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97 views

Does brain activity generate heat gradients in the brain?

I'm reading this article on guiding axon growth using temperature gradient, and it mentions that the trajectory of growth of neuron connections can be influenced by temperature gradients as little as ...
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0answers
35 views

Hippocampal regulation of hypothalamus

What is the difference between CA1-CA4 hippocampal subfields and dentate gyrus (DG) in negative regulation of hypothalamus? I`ve found only evidence that GR expression is more in CA1-2 and DG, while ...
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0answers
139 views

Does sexual arousal inhibit functions of prefrontal cortex in human females as well as males?

I've read somewhere, that when a human male experiences sexual arousal, his prefrontal cortex and, hence, his ability to reason and make rational decisions, is being heavily inhibited. Sounds pretty ...
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0answers
53 views

Carrying or packaging capacity of SAD B19 dG rabies virus

I'm wondering about the carrying capacity also referred to packaging capacity or loading capacity (how many base pairs can be packed efficiently into virions) of the pseudotyped rabies virus SAD-dG as ...
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0answers
19 views

Which Receptors are involved in Psychedelia/Psychosis?

Which receptors are involved in Psychedelia/Psychosis? I know that the 5-HT2A, 5-HT3, D2, κ-opioid and NMDA receptors are likely involved in psychosis.
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48 views

The relationship between the currents of intracellular and extracellular ions of a cell

In a cell, assume that only sodium, potassium, chloride and calcium ions can cross the membrane and their currents are: $I_{Na}$, $I_{K}$, $I_{Cl}$ and $I_{Ca}$, across the whole membrane. There is ...
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0answers
48 views

Does Dorsal Raphe Nuclei firing pattern change in response to voluntary breathing?

I'm reading this paper, which discusses how Serotonin may be involved in motor functions of mammals: 5-HT and motor control: a hypothesis . The paper includes the following diagram of the Dorsal ...
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31 views

What is the electrical frequency range of the spinal column?

What is the electrical frequency range of the spinal column? If there is a variance, how great or small is it?
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0answers
23 views

Spinal cord injury bypass

When the spinal cord is damaged, the connection between the brain and some part of the body may be lost. To restore this connection, some research are carried out, with mainly two different goals : ...
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19 views

spinal cord lesion and result in somatic sensation

Jimbo suffers a lesion to the entire right half of the spinal cord at the T6 level. A few weeks after his injury, his doctor tests his right and left legs for somatic sensation and tone. fill out her ...
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24 views

What percentage of possible proteins has been tested by human brain evolution?

When the human human brain is discussed, I frequently hear an argument that goes like this "If there was a simple chemical solution for people to be smarter, nature would've already found it". I'm ...
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90 views

The process of how you visually perceive objects?

Use the following terms to describe in detail how you visually perceive an object that you can see right now. Use the terms in order to correctly describe the sequence of events involved in your ...
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0answers
19 views

Stress regulation in mosquitoes

I was just trying to understand how in insects, specifically mosquitoes does the process of emergency responding, stress regulation take place? Or in simpler words how are flight, fright and fight ...
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0answers
32 views

Does pain scale with mammal mass?

Some biological features scale with the animal mass (see previous Q&A). Assuming the same concentration of nociceptors on the skin surface, I'm wondering how painful a 1 cm wound will be ...
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38 views

Do people with colorblindness have less cones or no cones of a certain type?

https://en.wikipedia.org/wiki/Color_blindness#Red.E2.80.93green_color_blindness Protanopia (1% of males): Lacking the long-wavelength sensitive retinal cones,   Deuteranopia (1% of males): ...