Small molecules involved in propagation of a nervous signal across the synapses.
1
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1answer
35 views
Inverse of dopamine reuptake inhibitor?
The wikipedia article on the dopamine transporter gives examples of some drugs whose effects are mediated by the inhibition of the dopamine transporter, such as cocaine and amphetamines. Are there ...
1
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1answer
41 views
Are there any neurotransmitters that trigger all neurons?
I'm reading into the basics of the nervous system, and am intrigued by neurotransmitters. I understand that certain neurotransmitters can trigger more than one neuron type, and may be used as ...
0
votes
1answer
61 views
Does one neurotransmitter travel all the way through the nervous system?
Nerve impulses of course go really fast, but the neurotransmitters have to travel through millions of nerves, so how can it go that fast?
Is it a sort of relay with lots of neurotransmitters taking ...
1
vote
1answer
101 views
Serotonin - Does being aroused make you sleepy?
My Psychology text book says Serotonin causes "Sleep, arousal levels and emotion"
Does this really mean that when you are being aroused, Serotonin is released, which in turn makes you sleepy? If so, ...
1
vote
0answers
53 views
Molecular cause of cramps, spasms and strengthening in muscles? (incl. intro to muscle contraction)
When motor neurons are stimulated to trigger an action potential, this potential propagates down the spine, eventually reaching a neuromuscular junction, causing the release of acetylcholine (ACh).
...
3
votes
1answer
56 views
Do serotonergic (5-HT2A-mediated) psychedelics elicit stimulant effects?
I know that 5-HT2A partial agonism is the key mechanism of action of serotonergic psychedelics but I also know that some research (e.g. the selective (no activity on any other known receptor sites) ...
3
votes
0answers
25 views
Are all Autoreceptors Downregulated by their Respective Endogenous Ligands?
I know that the 5-HT1A and $\alpha$2 adrenoreceptors receptors serve as autoreceptors for serotonin (5-HT) and norepinephrine respectively and are down-regulated by repeat exposure to their respective ...
2
votes
0answers
52 views
Why do antidepressants have a delayed onset of action?
Why do antidepressants take so long to reach efficacy? I've read of theories about it perhaps being due to the strength of negative feedback via serotonergic and adrenergic autoreceptors during the ...
2
votes
0answers
26 views
Do SSRIs downregulate or upregulate the 5-HT3 receptor?
What effect do SSRIs have on the expression of the ligand-gated ion channel, the 5-HT3 receptor?
4
votes
0answers
36 views
Do mammals develop tolerance to anticholinergics?
I know that first generation H1 antagonists, commonly known as antihistamines have anticholinergic effects. Their sedative side effects go away due to tolerance, but as for their anticholinergic side ...
3
votes
0answers
22 views
What Effect Does the Endocannabinoid System have on Monoaminergic Neurotransmission?
I know that Δ9-tetrahydrocannabinol and other cannabinoids increase dopaminergic neurotransmission in the nucleus accumbens and that this is what results in the euphoria experienced by cannabis users. ...
2
votes
1answer
67 views
What is the cannabinoid autoreceptor?
"Is there a cannabinoid autoreceptor? And if so what is the cannabinoid autoreceptor?"
(i.e. is the cannabinoid autoreceptor CB1, CB2 or is it one of the G protein coupled receptors, GPR18, GPR55 or ...
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0answers
22 views
Does regulate always mean suppress when it comes to heteroreceptors?
Do heteroreceptors always suppress the release of the neurotransmitter they regulate upon their (the heteroreceptor's) activation?
3
votes
2answers
139 views
Physiological indicators of happiness and well being
If I understand it correctly, levels of serotonin in the brain can indicate if a person is happy. What other physiological measures indicate happiness or well being for a humans?
I am looking for ...
3
votes
0answers
16 views
Does Doxylamine have any Influence on the Monoaminergic System?
Does doxylamine have any affects on the monoaminergic system? Specifically I am interested in adrenergic or serotonergic activity but additional information on its dopaminergic activity won't hurt ...
2
votes
1answer
49 views
Which Enzymes are Responsible for the Biodegradation of Noladin Ether?
Which enzymes degrade the CB1-specific endogenous cannabinoid 2-arachidonyl glyceryl ether? (Noladin ether)
2
votes
1answer
17 views
Which Enzymes are Responsible for the Biodegradation of Beta-endorphin?
Which enzymes are responsible for the biodegradation of the endogenous opioid peptide, beta-endorphin?
4
votes
1answer
49 views
Are serotonin levels in humans affected by light?
I'm reading this Wikipedia article on light therapy and noticed a peculiar statement:
The production of the hormone melatonin, a sleep regulator, is
inhibited by light and permitted by darkness ...
2
votes
3answers
158 views
Is there such thing as “half-life” of dopamine?
If a dopamine is released at T=0 and binds to receptor D2, what determines the time when the concentration of this neurotransmitter bound to the receptor reaches half of the original concentration? In ...
3
votes
1answer
79 views
What is the relationship between Homocysteine and Norepinephrine metabolic cycles?
I've been researching neuromodulators and have taken a look at the Norepinephrine/Noradrenaline system.
The diagram of biosynthesis of Norepinephrine is presented in the wikipedia article:
...
