This tag refers to how the body interacts with drugs such as how the body absorbs, distributes, metabolises and excretes (these four aspects of pharmacokinetics are often abbreviated ADME) said drugs.

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Anesthetics, specifically inhaled anesthetics

I have had a look at previous inhaled anesthetics and many of them appear to be fluorocarbons. What could be the mechanism behind fluorine's anesthetic properties? Is it the specific bonding pattern ...
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Does THC excretion increase if urine volume increases?

In regards to the body metabolizing and excreting THC: if urination is increased as a result of drinking lots of fluids, does that mean that more THC is leaving the body? To rephrase the question, is ...
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Why is drug clearance not affected by blood flow in case of low extraction ratios?

Background information: 1) Variation of organ blood flow: a) for drugs with low extraction ratio (<0.3): the venous drug concentration is virtually identical to the arterial concentration ...
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What is the most common way of administering loop diuretics and what is their time course of action?

I am reviewing some material on loop diuretics, and I am curious to know how these drugs are administered. Also, I am interested in knowing their time course of action once they are administered into ...
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Why do different pain killers have different effects on people?

I've noticed some pain killers working great for me, while other having no effect. Works for me Aspirin APC † Naproxen Doesn't work for me Paracetamol Diclofenac Tramadol I doubt there ...
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Thermochemistry of gabapentin

So I am taking a new class at my institution called Theoretic Nuclear Thermochemical Pharmacology, (I know big name, it's an elective from a real pioneering fronteirsman in our department :P) and I am ...
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Drugs metabolism and detection

If someone is taking treatment for a psychiatric disorder, for example diazepine, would traces of the metabolized drug show in their sweat or saliva? Would it be chemically detectable?Any links to ...
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Pharmacokinetics: why do certain drugs follow zero-order kinetics?

I understand that alcohol and phenytoin are two examples of drugs that follow zero-order kinetics. Why do these two particular drugs follow zero-order kinetics as opposed to first-order kinetics?
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Pharmacology Half Life Calculation

I'm really stuck on this question. I'm being asked to find the half life of a drug. The Vd is 50L/kg. The clearance is 0.1 L/hr/kg. The patient weighs 70 kg. Equation is: T1/2 (halflife) = 0.693 * ...
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What is the physiological difference between snorting/swallowing cocaine

I know that mucosa inside the nose absorbs cocaine molecules when snorting cocaine, but what difference is there compared to swallowing? Also more cocaine administration equals more cocaine molecules ...
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Why can't sodium butyrate be delivered orally in humans and other mammals?

I think I know why -- bioavailability problems but since I have no firm evidence to support this theory I thought I would ask the biology stackexchange community for their input. I'd like some firm ...