Pharmacology is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function

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Why are many anti-malaria drugs gap junction antagonists?

Why are many anti-malaria drugs gap junction antagonists? My professor recently just mentioned that many of the anti-malaria drugs block gap junctions. i am wondering if this blocking is important ...
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49 views

Is half-a-tablet of X a substitute for a tablet of X/2?

This may be anecdotal. At the pharmacy earlier, the prescription called for a drug with X mg of the target chemical. The pharmacy however only had stock of a higher potency of the same brand. E.g. ...
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33 views

Can a fungus become resistant to a chemical such as Potassium Permanganate?

A friend used potassium permanganate solution to treat tinea on the hands/feet but after some initial success, the tinea seems to be making a comeback. Could the fungus develop resistance to potassium ...
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17 views

Does Yerba Mate contain Beta carbolines like harman and norharman?

I know that this is true of (roasted) coffee but haven't been able to find any reliable information about mate in its smoked or steamed state. Thank you.
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26 views

Sleep: a tale of two morning stimulants

According to "common knowledge", morning/afternoon exercise is "good" for sleep (in the long run) and caffeine is bad (less so in the morning). However, both of these stimulate the brain; exercise ...
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42 views

How to relate human metabolic model reactions and cancer drug targets / reactome items?

Trying to find a way to take a cancer drug (from CancerDR, for instance) and infer the metabolic reactions that are affected by it in the Human Metabolic Model. Essentially, I would like to know ...
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38 views

How does a smoker's pleasure work?

I smoke. For some reason, I've always had this idea that the pleasure of smoking works more or less like this: from the lungs, the nicotine reaches the blood, with which it travels to the brain, and ...
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1answer
40 views

Can cerebrospinal fluid deliver nutrients/drugs to neurons during sleep?

I'm looking at this article on the possible mechanism of detoxifying brain during sleep using cerebrospinal fluid. It states that at night, the space between neurons may allow better (up to 20x) ...
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24 views

Beetroot white skin mould

Does a mould make a beetroot poisonous or inedible ? Lemon's mould for instance, makes penicillin, but it's green there, and I'm allergic to penicillin, would the white mould produce penicillin too? ...
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1answer
51 views

How is it decided that one drug is better than others by X times?

I read in Tortora and Derrickson that : Enkephelins are 200 times powerful than morphine in their analgesic effects. I wonder how exactly researchers arrive at a number (like 200 here). I also ...
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39 views

What is the best way to orally administer a water insoluble powdered drug to macaque monkeys?

They typically need to be given ~150mg, once a day, and it'll last for two weeks. The drug is very water insoluble, becomes almost like a paste, not suitable for tube feeding. And yes, this is for for ...
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59 views

When might an inhibitor of bacterial transformation be useful?

I am part of a project elucidating some structures that are required for bacterial transformation. We have the opportunity to screen inhibitors of the system to stop it from functioning. I am not a ...
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2answers
59 views

Epinephrine vs. Adrenaline

Both names are widely used, with what appears to me as a slight prevalence of “epinephrine” in scientific literature and an overwhelming prevalence of “adrenaline” in popular media. Are there any ...
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16 views

Why is it that alpha-2 adrenoceptor agonists haven't been tried, in clinical trials, as an adjunct to PDE4 inhibitors?

Phosphodiesterase 4 (PDE4) inhibitors such as rolipram and piclamilast have demonstrated a number of potential therapeutic effects in preclinical studies and even the odd clinical study, but their ...
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1answer
17 views

Function of an VEGF inhibitor in the treatment of macular degeneration

I'm working on a short presentation of treatments of macular degeneration for a biomedical optics seminar on macular degeneration. Since I don't have any relevant medical or biological background ...
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1answer
49 views

Dimethyltryptamine and Sigma 1-type opioid receptor interaction

Where exactly do dimethyltryptamine and sigma 1-type opioid receptor interact? I read in this When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor but it ...
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36 views

Does DHA increase the effects of clarithromycin?

I've read on this publication that every drug that induces CYP3A can reduce the effectiveness of clarithromycin. Clarithromycin inhibits CYP3A. But it does not say anything about the opposite ...
2
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1answer
307 views

Which is the tissue damaging agent in krokodil (street desomorphine)

I've just read about krokodil and saw some quite hideous pictures about what it does to the human body. I guess just desomorphine alone wouldn't have this effect. Which ingredient(s) causes the ...
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51 views

What's the Mechanism of Paradoxical Excitatory Effects with Sedating Antihistamines?

I've been reading the British National Formulary 65 (BNF-65) and it mentioned that in some, especially at higher dosages, sedating (first-generation) antihistamines, can produce paradoxical excitatory ...
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0answers
68 views

Why can't sodium butyrate be delivered orally in humans and other mammals?

I think I know why -- bioavailability problems but since I have no firm evidence to support this theory I thought I would ask the biology stackexchange community for their input. I'd like some firm ...
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2answers
29 views

What Role Antagonists Play in the Study of Drugs?

I am pretty unfamiliar to pharmacology. I'm doing a research on drug abuse, particularly opioids' mechanism of action. I encountered several times evidences that come from studies using antagonists ...
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2answers
68 views

Assays during drug discovery

After researching the definition of Assay, I am left with the idea that an assay refers to scientific screening. It could be of chemicals, microbes, etc. I understand that during drug-discovery ...
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596 views

What are potential side effects of myostatin inhibitors?

Myostatin inhibitors, which are being developed to treat muscle wasting diseases like muscular dystrophy, are likely to be abused by athletes. What are the potential long-term side-effects of taking a ...
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135 views

Why are there so many medicinal plants?

Here is wikipedia page containing a list of plants used in herbal medicine. One might first want to argue that many of them actually do not have any medicinal/beneficial effect on heatlth. I think we ...
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35 views

How does Scopolamine Produce Antidepressant Effects?

I know that scopolamine has rapid and robust antidepressant effects in a few placebo-controlled trials but I can't seem to find out how exactly, even just potential mechanisms would be great if they ...
2
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2answers
178 views

Are there dangers to Teflon and aluminium cookware?

I've been reading some articles on the internet about dangers of Teflon and aluminium to the body. My family say I'm just exaggerating the situation, and maybe I am, though I'm not sure because not ...
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28 views

What Effect would Cannabinoids have on the Acute Porphyrias?

I should be clear in saying that this question is NOT intended for personal medical advice. Rather what I am looking for is journal articles and/or books that touch on this subject because I think it ...
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34 views

Selective Androgen Receptor Agonist

I'm looking for an inducer that strongly activates the androgen receptor, but not the glucocorticoid receptor that is not DEA regulated. I know that SARMS (Selective Androgen Receptor Modulators) are ...
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1answer
496 views

What is a pA(2) value?

I saw this article http://www.ncbi.nlm.nih.gov/pubmed/16710314 and it mentioned pA(2) values and I had no idea what they were. What are they? What do they mean? If possible it'd be just dandy if you ...
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42 views

Can ingestion of B6 cause gastrointestinal disturbance?

Can the ingestion of vitamin B6 upset the stomach, and if so by what mechanism?
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188 views

Why do antacids have a special importance when taking lactulose?

“Before taking lactulose, tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antacids, antibiotics including neomycin (Mycifradin), and other ...
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58 views

How is ammonia removed from the colon?

“Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease. It works by drawing ammonia from the blood into the colon where it is removed from the body.” ...
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34 views

Do antidepressants with their BDNF expression-increasing effects display disease-modifying effects in Alzheimer's disease?

I ask this question because I've looked everywhere I can think of and not one mention of this even though it definitely makes sense based on the finding that antidepressants increase brain-derived ...
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85 views

Inverse of dopamine reuptake inhibitor?

The wikipedia article on the dopamine transporter gives examples of some drugs whose effects are mediated by the inhibition of the dopamine transporter, such as cocaine and amphetamines. Are there ...
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1answer
64 views

What are the characteristics of a promising drug target?

When researchers are looking to start developing a drug, what characteristics do they look for in the potential proteins (assuming they already have good quality structural models)?
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47 views

Are there any examples where 'magic bullet' drugs have worked?

Magic bullets are drugs that can be administered on a micro local scale near the tumour by exploiting the different surface antigens that cancers expose. The drug attaches via an mAb (attached to the ...
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1answer
54 views

What is the disadvantage of having no anticoagulation after pulmonary embolism?

Is chronic anticoagulation always given after pulmonary embolism? What are the risks or disadvantages if anticoagulation is not given? if terminated early?
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1answer
104 views

How do you average Ki values?

It's embarrassing for me to ask this but well such is life. NIMH Psychoactive Drug Screening Program (PDSP) Ki Database is mentioned as the source of the average binding affinity (Ki) values given in ...
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50 views

How does Pethidine Contribute to Serotonin Syndrome?

I ask this because while I did read in this Australian Government webpage that it inhibits the reuptake of serotonin I have seen no studies that have mentioned any such interaction with the serotonin ...
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20 views

What are the conditions that must be satisfied in order for drugs to be deliverable via the epidural route?

I ask this because I've read that while pentazocine is approved by the FDA for the treatment of labour pain, epidural administration is not listed as one of its means of administration (which thing I ...
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2answers
161 views

What's a good and reliable database on the pharmacodynamic and pharmacokinetic data of drugs both approved and unapproved?

What's a good and reliable database for the pharmacodynamic and pharmacokinetic data of drugs both approved (in the US and elsewhere) and unapproved?
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30 views

What's the mechanism of action of Levomepromazine's analgesic effects?

I have absolutely no idea as to how Levomepromazine elicits its analgesic effects so please do direct me to journal articles and other credible sources with you, the answerer, making a summary of ...
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51 views

Which receptor in particular does, “MUSCARINIC CHOLINERGIC” refer to in Goodman and Gilman?

On pg. 410 of Goodman and Gilman's The Pharmacological Basis of Therapeutics 12th Edition the term "MUSCARINIC CHOLINERGIC" is used (in the context of side effects of antidepressant agents) with ...
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113 views

How does Tianeptine work to elicit its therapeutic effects?

Tianeptine is an antidepressant and anxiolytic that has some additional analgesic properties that's used in some European countries, and the theories I've heard about how it works include the ...
2
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1answer
88 views

Confusion related to a term probe-by-background interaction

I was reading a paper related to bioinformatics where it uses the drug response on the cancer cells and the gene expression of the individual cells are studied to find any useful insights. Specially, ...
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1answer
244 views

How exactly does marijuana damage brain cells?

I've heard that THC can cause permanent damage to brain cells. I've also heard this reffered to anti drug propaganda. Another theory i've read is that temporary effects reduce intelligence but long ...
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1answer
158 views

Definition of Dye- Reduction Test?

Can some one give a simple explanation or definition on what a dye-reduction test is.
0
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1answer
71 views

Which Enzymes Catalyse the Deacetylation of Drugs in the Human Body?

If you would like more specifics seeing how I realise that this question is very broad and may be difficult to answer in general then hopefully the following will help you out: I am particularly ...
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1answer
39 views

What does “Psychomodulatory” mean in the context of potentially psychoactive drugs?

What does "Psychomodulatory" mean in the context of potentially psychoactive drugs? That is, in this journal article http://www.sciencedirect.com/science/article/pii/S0028390812001931 in the ...
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52 views

Is there a Pharmacology Textbook that Satisfies the Conditions listed in the Body of this Question?

The conditions are: As extensive and explanatory as Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition With additional extensive and thoroughly explanatory information ...