Pharmacology is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function

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Aspirin - does it inhibit enzyme of thromboxane?

This is a diagram a friend showed me about the drug aspirin, where we were arguing which enzyme it prevents. Aspirin is known to inhibit the production of prostaglandins. However, it also serves ...
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38 views

Does medication make the body dependent? [closed]

First of, I know of course that certain medication can cause an addiction if incorrectly used. But as far as I understand it, drugs prone to cause addiction have some agent in it, that makes them ...
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247 views

How does paracetamol work?

Hinz et al. 2008 found that COX-2 may be inhibited by paracetamol, and this is attributed to it's analgesic and antipyretic properties. However there are other more recent claims from Andersson et ...
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66 views

Blood draw from the elderly or those with tiny veins

A lot of people have very small veins making it next to impossible to draw blood. Would a nitroglycerin tablet (or some other vasodilator) before drawing blood help to enlarge veins?
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What are necessary parameters for a tissue scaffold to be biodegradable?`

I am a mechanical engineer with little biological experience, but I have recently been looking at tissue scaffoldings. My current understanding is as follows, but may be flawed. I would appreciate ...
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60 views

How to determine sensitivity in a dose-response curve?

In a dose-response curve the % inhibition can be plotted against concentration antagonist. In our case, the effect of the antagonist is tested in different genetic variants of a microbe. When trying ...
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89 views

Homeopathy is placebo, but isn't placebo good?

I never considered homeopathy as a serious and scientific medicine, and now we have plenty of evidence supporting this ...
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How do macromolecules (large drugs) in the eye reach the bloodstream and what are the relative significances of these pathways?

I am considering the elimination pathways for antibodies (50-150 kDa) from the vitreous humour to the blood stream. My overarching question is what is the most significant route such antibodies could ...
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28 views

Infection of urinary tract if the pH of urine is made alkaline

It is very well known that drugs like phenobarbiton,morphine are unionized, lipid soluble.So,in case if there is toxicity due to these drugs,the only way to save the patient is make the pH of urine ...
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28 views

Genotype-Phenotype databases?

Beyond the Stanford HIV database, what other databases out there provide a dataset linking virus/bacterial genotype to quantitative phenotype? I'm looking for high quality datasets to test machine ...
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124 views

How do antibiotics create drug-resistant strains

I've heard for years that low-level use of antibiotics causes the spread of drug-resistant strains of bacteria, but the explanations always fall short. I understand mutations and natural selection, ...
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79 views

Do drugs' levo isomers have a better interaction with the receptors in our body than dextro isomers?

Examples of levo drugs include levothyroxine, levocitrizine, and levodopa. Is there any specific reason why the receptors in our body exhibit this stereoisomerism and hold a high preference for the ...
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61 views

How does Tylenol relieve pain without making me drowsy?

So I have a crown that popped out and has been killing me, I've lived on a steady diet of Tylenol since it popped out. I've noticed that aside from killing most of the pain from the tooth, the tylenol ...
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61 views

Difficulty in finding protein inhibition drugs

I was reading an article on a recent identification of a PARP-14 protein in cancer cells that is responsible for production of additional glucose which keeps cancer cells from dying, and that a ...
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40 views

Western blot extrange band

I performed a WB using plasma rats and monkeys samples with anti ubiquitin K-48 antibody. In every sample the antibody binds something and it appears a specific band that seems to be 71kDa. When I ...
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34 views

Birth control hormones in the water? Or not?

This prior question talks about natural estrogen (TL;DR: Months to years): How quickly do estrogens break down in the environment? Ref: http://dx.doi.org/10.1038/485441a A lot of media has said, ...
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Do spinal cord reflexes (such as the knee-jerk reflex) continue to function under general anaesthesia?

The knee-jerk reflex (patellar reflex) is an example of a stretch reflex (myotatic reflex). Stretch reflexes are monosynaptic reflexes happening in the spinal cord without involvement of the brain. ...
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38 views

Chemotherapy - Hair loss

Chemotherapy kills cancer cells by targeting rapidly growing cells. That is why patients are loosing hair as well. My question is, why chemo related hair loss is temporary ? The docs say it is ...
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18 views

Source of journals collecting titles of scientific publications regarding clinical trials with dogs fed medicinal herbs

After some time researching on the web, you can find a lot of websites telling you that some herbs may have or have specific properties(unfortunately most seem to be "advertised" as if they were ...
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39 views

How does drug-induced photosensitivity work?

Some drugs (tetracyclines, for instance) can cause photosensitivity reactions—that is, some patients become extremely sensitive to the sun, developing rashes or inflammation after spending time ...
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How much penicillinase is needed to deactivate 125mg of amoxicillin?

How much penicillinase is needed to deactivate 125mg of amoxicillin? Penicillinase in penase concentrate from CPC. 20,000 Levy Units/ml/min I need IU of 125 mg of amoxicillin. Please note that the ...
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246 views

Have webs woven by LSD-intoxicated spiders ever been studied for their efficiency in fly catching?

I ask, because I have a different interpretation of the experiments performed on web-weaving spiders. The famous Robert Pirsig maintains that LSD is somehow helpful to web-weaving spiders, because it ...
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15 views

What is the permeability of proteins across the hyaloid membrane of vitreous to retina?

Does anyone know of any experimental work to test the permeability of the hyaloid membrane between the vitreous humour of the eye to the retina to proteins? Currently the largest molecule I can find ...
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65 views

Can the liver prioritize it's metabolizing potential?

Let's assume we have two toxins - one of which is routinely metabolized by the liver, and the other is new to the organism (consider for example alcohol in a heavy drinker and any other drug that is ...
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If a blocker prevents repolarization, will the neuron be stuck in a depolarized state forever?

Potassium channels help to repolarize the cell after depolarization. But if the potassium channels are blocked, potassium ions cannot flow out of the cell to increase the membrane potential. Thus, one ...
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What's the relationship between Drugbank drugs and SMPDB pathways?

In the 'pathway browse' panel SMPDB pathways and their corresponding Drugbank drugs are listed. What are the relationships between the drugs and the pathways? Some listed drugs are not in the ...
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49 views

Why doesn't Manipulated Virus for Cancer Cure Work [closed]

I'm not a biologist but I have an idea for a cure for cancer and it is very simple and probably has flaws (if it worked it probrably wouldn't be a cure for all) or is not possible but ... I'm still ...
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How do drugs (or other molecules) move between the vitreous humour and aqueous humour of the eye? [duplicate]

My question is regarding the biological nature of the separation between the vitreous humour and aqueous humour of the human (or mammal) eye. What connects the two in terms of the passive transport of ...
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172 views

Why is dopamine or a dopamine-receptor agonist not pumped into the brain of Parkinson patients?

I am aware that dopamine cannot cross the blood-brain barrier, but can't it be pumped inside the cerebrospinal fluid via some permanent tube implant? Wouldn't Parkinson patients chose that over ...
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Can I explain the kinetics of a ligand looking at the ligand-protein co-structure?

Can I explain the kinetics of a ligand binding to a target protein (association and dissociation rates) by looking at the protein-ligand co-structure? Editing my question after a few comments: I ...
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283 views

IC50 and area under the curve

I was hoping to get some clarification on how drug response data (i.e. IC50) are presented. On publicly available datasets like Genomics of Drug Sensitivity in Cancer, area under the curve (AUC) ...
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2answers
130 views

Defining Resistance and Sensitivity Thresholds for IC50

I have a dataset containing IC50 data for each of my cell lines and up to 80 drugs. Basically for each drug I want to be able to define an IC50 threshold where if a cell line has an IC50 above that ...
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107 views

Why is cisplatin a very potent antineoplastic for testicular cancer, but not necessarily for other cancers?

Cisplatin (structure below) is a platinum-based chemotherapeutic agent which is very effective in the treatment of some cancers. Its introduction was responsible for improving the cure rate for ...
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Does inhaling glue (glue sniffing) reduce appetite?

I have heard from many homeless people that they sniff glue just to reduce appetite, as it comes cheap and is more affordable than actual food. Is this true, and if yes, why? This is totally opposite ...
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114 views

How does amiodarone act as an alpha and beta blocker?

Amiodarone is potassium channel blocker but also voltage-gated Na+ channel blocker according to Pubchem. However, upon reading my notes I discovered Amiodarone blocks potassium channels and block ...
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Why is Benzylpenicillin better in Bacterial Meningitis than Amoxicillin?

Both are beta lactams. However, benzylpenicillin, which is also called penicillin G i.e. narrow group antibiotic. I have now in both the following as a mechanism of action Binds to PBP in ...
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47 views

Is dinoprost PGF2-alpha or PGE2?

In many places it says PGF2-alpha. Now, I am thinking PGE2 is a substype of PGF2-alpha. However, I am not sure. Is dinoprost PGE2?
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Doxorubicin's intercalant and topoisomerase inhibition in leukemia?

I am thinking the role of doxorubicin's pathways in cancers such as leukemia and lymphoma: topoisomerase inhibitor and inhibit DNA activity intercalant - intercalant DNA bases and inhibit DNA ...
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Imidazoline receptor agonist in clonidine?

I am thinking which pathway is more important in hypertension, ADHD and withdrawal of clonidine: alpha-2 agonist imidazoline receptor agonist (maybe) Alpha-2 is the classical one. Pubchem starts ...
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1answer
223 views

Why is Electrical Cardioversion contraindicated in AF and Digitalis Poisoning?

I am thinking why electrical cardioversion is contraindicated in atrial fibrillation with digitalis toxicity/poisoning. Cardiac digitalis is also called digoxin and cardiac glycoside. It is ...
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2answers
282 views

What is “theae folium”?

I wanted to buy black tea at a pharmacy and the pharmacist told me that russian tea is actually black tea so I bought it instead.It's made out of theae folium leaves and for some reason I can't find ...
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102 views

Does homeopathic or herbal treatment of cancer have any scientific recognition?

Even though we have a very high tech society, cancer is still a serious issue. We humans still are not entirely capable of fighting cancer. Radiation and chemotherapy are still considered the best ...
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80 views

Do both Carbamazepinum and Lamotriginum increase glutamate threshold?

I have in my notes that: Carbamazepinum increases threshold for glutamate Lamotriginum delays release of glutamic acid I would like to simplify these sentences into a single line. I would like to ...
4
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81 views

Relationship between toxicity of drugs and negative effects on brain

Are psychoactive drugs with lower lethal doses more neurotoxic (more damaging to the brain)? For example, tetrahydrocannabinol (one of the active components of cannabis) has a much higher lethal dose ...
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62 views

Consuming animals by slaughtering vs injecting barbiturates?

In "Least painful way to die" we get an answer ... Companion animals (e.g., dogs and cats): injected barbiturates are recommended Laboratory animals (e.g., mice and rats): injected ...
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2answers
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The effect on the efficacy and potency of a non-competetive antagonist binding to the active site of the receptor (dose-response curve)

According to the book "Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy" by Golan et al, non-competetive antagonists can bind to both the allosteric site and the active site. I ...
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72 views

Why are pharmacology studies so experimental?

I am a med student, and as far as I see from our pharmacology lectures, pharmacologists work almost completely experimental. Quite typically they take a substance (e.g., from nature), they add, change ...
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102 views

Given an EC50 value, how do I reproduce the sigmoidal curve from which this was calculated?

All-trans retinoic acid (atRA) is a potent ligand for a nuclear receptor called retinoic acid receptor alpha (RARa). The concentration of atRA at which RARa is half maximal is 19nM. The dose-response ...
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Why is there only adrenoreceptors and no active adrenergic innervation in bronchus and uterus?

Our bronchus and uterus has beta adrenoreceptors, but they have no active sympathetic nervous system innervation in these organs. Was there a sympathetic innervation in trachea and uterus, earlier, ...
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179 views

How to define drug-resistant or -sensitive cell line when knowing the IC50 values?

I have got the IC50 data for a drug on different cell lines. How to define if the cell line is sensitive or resistant towards this drug? Could anyone tell me how to define this?