Pharmacology is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function

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Spironolactone's role with adrenergic agents in heart failure?

I am studying the treatment plan of adrenergic agents for heart failure. Then, in the group discussion, spironolactone was included. But I cannot understand how it is relevant when considering ...
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28 views

Reason why sedative drugs stem from eastern countries and stimulating drugs from western ones [on hold]

I was wondering if there's a linkage between the geographic distribution of drugs and their effects. There's nicotine, caffeine and cocaine, all originating from south-america and all of them have ...
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31 views

Anesthetics, specifically inhaled anesthetics

I have had a look at previous inhaled anesthetics and many of them appear to be fluorocarbons. What could be the mechanism behind fluorine's anesthetic properties? Is it the specific bonding pattern ...
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34 views

Are ipratropium and tolterodine parasympatholytic?

They are nonselective cholinoblockers and antimuscarinic. Other cholinoblockers of parasympaticus, which I know, are parasympatholytic such as atropine, butylscopolamine, trihexyphenidyl, titropium ...
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13 views

Differentiation of norepinephrine and epinephrine in indications

Norepinephrine is less beta2 adrenomimetic than epinephrine so more selective so less bronchospasm so may be therofore better in treatment of cardiac failure and different shocks. However, I am not ...
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17 views

How can Pyridostigmine have the indication of Myasthenia?

I am thinking how pyridostigmine can be used in the treatment of myasthenia gravis. Its similar compound (neostigmine) is also anticholine esterase. This compound has the indication of myasthenia ...
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41 views

To understand side-effects for nebivolol's beta1 selective pathway in PubChem? [closed]

Assume you have a drug nebivolol. When nebivolol is used as beta1 selective drug, beta2 is mostly for side effects, but this is not clear from PubChem. I do not know any cases where nebivolol is used ...
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33 views

Clonidine's adrenonergic nature?

I am little confused here. I used the term adrenoagonist and sympatholytic to describe the compound. However, my teacher says that the correct term here is adrenomimetic -term. My understanding of ...
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26 views

What is the mechanism of action of lithium-induced polyuria?

I was reading in my pharmacology textbook on lithium in treating bipolar disorder, and I was curious to know if there was any specific action lithium takes to produce symptoms such as polyuria and ...
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17 views

To Study Interactions of two molecules in PubChem

Assume you have two substances Diosminum / Hesperidinum. The former strengthens vascular walls. The latter has role in some glycoside biosynthesis. From Biochemistry, I recall that glycodises have ...
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18 views

Salbutamol's Pathways of Interaction and Classification

Salbutamol is a very commonly used direct-acting β2-agonist. This suggests me that it is sympatholytic. However, it has sympathomimetic pathways, see PubChem for Sympathomimetic. I am trying to ...
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12 views

Ephedrine or pseudoephedrine indirectly central alpha2 mimetic?

I started to think this problem by first thinking if the alpha2 mimetism is possible in either case. It seems to be indirectly in either one. Ephedrine seems to have more prominent effect in CNS. ...
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23 views

Is Norepinephrine beta2 adrenomimetic?

I know that it has alpha1, alpha2 and beta1 effects. It has beta2 receptor where epinephrine can effect. However, to say that it is beta adrenomimetic, I am not sure. That is ligand binding beta2 ...
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22 views

How can succinylcholine cause myorelaxation?

I first thought that this is because of prolonged depolarisations. However, I am not sure anymore, because after reading PubChem, the only possible pathways are are Choline agonist. So I would say ...
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21 views

Quetiapine tolerance

I've researched quetiapine for quite some time now and I've found some references to tolerance, but nothing conclusive. My question is whether quetiapine use builds tolerance to the drug and if so, ...
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19 views

Why is drug clearance not affected by blood flow in case of low extraction ratios?

Background information: 1) Variation of organ blood flow: a) for drugs with low extraction ratio (<0.3): the venous drug concentration is virtually identical to the arterial concentration ...
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18 views

What is the most common way of administering loop diuretics and what is their time course of action?

I am reviewing some material on loop diuretics, and I am curious to know how these drugs are administered. Also, I am interested in knowing their time course of action once they are administered into ...
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26 views

Does vitamin D form crystals in the blood with calcium and magnesium?

I read on a vitamin-D product (2000NE) that I should not use calcium and magnesium with it, because it can result crystal formation in the blood. I googled, but find anything about this. Is it true? ...
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67 views

Why does caffeine give you so much energy, while being so low on calories?

There's definitely something I'm missing here. Since calories is a unit of measurement for energy, and caffeine seemingly gives you a lot, how can the labels on caffeinated products have such a low ...
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26 views

What are the reactions in the body that triggers dizziness after cigar(nicotine) smoking in non-smokers?

Suppose there is a person that has never used nicotine in any form in his/her life. Why does the person get dizzy after a few "shots" from a cigar(nicotine)? What's the difference between using other ...
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13 views

What enables azacitidine to incorporate into both DNA and RNA?

I did a mini-project on the drug azacitidine for my pharmacology class, and I learned that azacitidine has the ability to incorporate into both DNA and RNA. I think this is really unique because a ...
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32 views

Concentration of caffeine in physiologically relevant setting

Caffeine is known to overcome G2/M (and possibly other types of) cell cycle arrest through its effects on DNA repair machinery and is used as a positive control in studies of cell cycle arrest. In ...
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30 views

Difference between medicinal caffeine and regular caffeine

There are some OTC paracetamol tablets, some with caffeine. Is this caffeine the same as the regular caffeine (found in a coffee)? Does it perform better than it in any way?
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46 views

Which immunosuppression caused by long-term usage of these antibiotics in untreated celiac disease?

These antibiotics include amoxicillin + acidum clavulanicum (beta-lactam, inhibit cell wall synthesis, broad specturm, 3rd gen aminopenicillin) / last part preventing the resistance ceftriaxone (3rd ...
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29 views

Is there a known glucosepane cross-link breaker?

I read the following on wikipedia: There is, however, no agent known that can break down the most common AGE, glucosepane, which appears 10 to 1,000 times more common in human tissue than any ...
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What studies are there showing the effectiveness of any substance on canine hypertension?

Searching on http://www.ncbi.nlm.nih.gov I could only find the article titled as "Telmisartan Treatment of Refractory Proteinuria in a Dog".
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What are the psychedelic effects of (stellar) anise and how many people are affected?

Backstory: My girlfriend reacts heavily to chocolate and drinks containing stellar anise, in a way that seems comparable to psychedelic drugs. After consuming it, it takes approximately five minutes ...
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26 views

How does fluorouracil inhibit pyrimidine synthesis?

I was reading in my pharmacology textbook about fluorouracil, and my book mentioned that fluorouracil is an antimetabolite whose function is to inhibit pyrimidine synthesis. However, I was curious to ...
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154 views

Why do different pain killers have different effects on people?

I've noticed some pain killers working great for me, while other having no effect. Works for me Aspirin APC † Naproxen Doesn't work for me Paracetamol Diclofenac Tramadol I doubt there ...
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24 views

Thermochemistry of gabapentin

So I am taking a new class at my institution called Theoretic Nuclear Thermochemical Pharmacology, (I know big name, it's an elective from a real pioneering fronteirsman in our department :P) and I am ...
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19 views

Meta-analysis of fruits in blocking Cytochrome family

My professor says that some drugs cannot be used with grapefruit. I am trying to search a list of cytochromes and their effect to block members in the cytochrome family. Some in Cyt P450. What is ...
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37 views

Drugs metabolism and detection

If someone is taking treatment for a psychiatric disorder, for example diazepine, would traces of the metabolized drug show in their sweat or saliva? Would it be chemically detectable?Any links to ...
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32 views

What is meant by drug tolerance?

What is meant by drug tolerance? This question is in my biology textbook for IGCSE and I have no idea what drug tolerance is. It would be very helpful if someone could clarify. Thank you.
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Pharmacology: Drug Administration

Why is the enteral route seem by far the most common way to administer a drug to the body?
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104 views

Pharmacokinetics: why do certain drugs follow zero-order kinetics?

I understand that alcohol and phenytoin are two examples of drugs that follow zero-order kinetics. Why do these two particular drugs follow zero-order kinetics as opposed to first-order kinetics?
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Applying drugs to brain via scalp (transdermal)

Many medications are intended only for the brain, but are taken orally. Hence <10% finds its intended target, while the remaining >90% is at best wasted, and at worst causes unwanted side-effects. ...
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39 views

Compatibility drugs info

Let's suppose that I take a DrugA for ProblemA and then I got this ProblemB and started to take DrugB. Are there general rules I can look up to figure out whether I can take DrugA & DrugB ...
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Is there any completely Computation Drug ever launched in market?

I am working in bioinformatics(part of it in Drug Designing) for years, still if I have no idea about it. As it is too hard to prove (Pass all Clinical trials) and get FDA Approvals. So, My question ...
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144 views

What is LD50 for 25i (25I-NBOMe)?

Firstly I would like to apologise if this is not correct place to ask this question, as it can be seen more as chemistry and not biology question. I was looking around for data on psychedelic ...
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53 views

Can neurotransmitter depletion cause short-term drug tolerance?

I'm curious to know if neurotransmitter degradation factors into drug tolerance and neural conduction and, if so, to what extent. As I recall from textbooks I read as an undergrad, one mechanism of ...
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How does Sodium Valproate cause neural plasticity

I have been reading a fascinating paper: Valproate reopens critical-period learning of absolute pitch 18 individuals were given Sodium Valproate (VPA) for a fortnight during which they trained on a ...
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1answer
62 views

Mesoporous silica particles as anti cancer drug delivery method

If this question is a little off topic for Biology, I'm sorry. I've recently read a lot about mesoporous silica nanoparticles as a promising drug delivery method. The huge range of customizability of ...
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1answer
28 views

Classify chemotherapy drugs?

I'm studying a TCGA dataset trying to find correlations between gene expression and clinical data which might shed light on some pathways. One column of the clinical data provides a list of ...
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71 views

Does tea have its effect if you have a sleep after drinking it?

If I drink tea, then go to sleep for a while, when I wake up, will the effect of tea still be on me (the refreshing effect)? Does it depend on the duration of sleep?
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62 views

Pharmacology Half Life Calculation

I'm really stuck on this question. I'm being asked to find the half life of a drug. The Vd is 50L/kg. The clearance is 0.1 L/hr/kg. The patient weighs 70 kg. Equation is: T1/2 (halflife) = 0.693 * ...
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77 views

Elevated position effect on recovery times from upper respiratory infections at rest?

In nursing school, they advice for people with upper respiratory infections to be in a slightly elevated position at the head region when sleeping. My intuition of the reason is that the lymphatic ...
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67 views

What is the effect of Montelukast on the amount of IgE in blood?

I know that it decreases the amount of leucotrienes in blood. I saw a patient with high IgE altough under Montelukast medication. This suggests me that Montelukast does not affect the immunoglobulins, ...
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Could super-caffeinating somebody's bloodstream be dangerous?

I'm currently planning out an RPG based on Misfits. Basically young offenders get super powers. I want one of the villains to have a really lame power that they use to become incredibly dangerous. I ...
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42 views

Preventing paracetamol overdose

Paracetamol overdose is one of the most common drug toxicities. It may be treated by intravenous N-acetylcysteine which replaces the glutathione that is used up in paracetamol metabolism to prevent ...
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Name of scientist who discovered lifesaving drug and chose not to patent it?

I recall reading about a 20th century scientist who made a life-saving drug that could have patented it and made millions. He chose not to and saved the lives of millions around the globe. I thought ...