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1answer
52 views

Dimethyltryptamine and Sigma 1-type opioid receptor interaction

Where exactly do dimethyltryptamine and sigma 1-type opioid receptor interact? I read in this When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor but it ...
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1answer
137 views

Does the NMDA antagonist, Memantine that's used to prevent Excitotoxicity cause brain damage?

Does the NMDA antagonist, Memantine that's used to prevent excitotoxicity in Alzheimer's disease (AD) and Dementia with Lewy Bodies (DLB) cause brain damage? I know that in rodents NMDA antagonists ...
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1answer
100 views

Do serotonergic (5-HT2A-mediated) psychedelics elicit stimulant effects?

I know that 5-HT2A partial agonism is the key mechanism of action of serotonergic psychedelics but I also know that some research (e.g. the selective (no activity on any other known receptor sites) ...