1
vote
1answer
56 views

How to relate human metabolic model reactions and cancer drug targets / reactome items?

Trying to find a way to take a cancer drug (from CancerDR, for instance) and infer the metabolic reactions that are affected by it in the Human Metabolic Model. Essentially, I would like to know ...
2
votes
2answers
191 views

Why are there so many medicinal plants?

Here is wikipedia page containing a list of plants used in herbal medicine. One might first want to argue that many of them actually do not have any medicinal/beneficial effect on heatlth. I think we ...
5
votes
1answer
51 views

Selective Androgen Receptor Agonist

I'm looking for an inducer that strongly activates the androgen receptor, but not the glucocorticoid receptor that is not DEA regulated. I know that SARMS (Selective Androgen Receptor Modulators) are ...
0
votes
1answer
77 views

Which Enzymes Catalyse the Deacetylation of Drugs in the Human Body?

If you would like more specifics seeing how I realise that this question is very broad and may be difficult to answer in general then hopefully the following will help you out: I am particularly ...
5
votes
1answer
356 views

What is the biological mechanism underlying caffeine intolerance? (CYP1A2 or other?)

As far as I can tell, caffeine metabolism occurs primarily via the CYP1A2 enzyme. I am curious as to whether mutations in the CYP1A2 gene are associated with caffeine intolerance. Some site that is ...
2
votes
1answer
451 views

Circulation through the liver in light of drug metabolism

I have a lingering question which stems from an answer that I gave to What hydrolyses aspirin within the digestive tract and blood stream? When a drug or any other substance is absorbed into the ...
9
votes
1answer
181 views

What are the effects of caffeine on the mammalian circulatory system?

A friend of mine told me an anecdote about his mother, who drank too much caffeine, to the point she became hypotensive and would pass out. Because caffeine acts as a stimulant, I'm assuming the ...