1
vote
1answer
40 views

Can cerebrospinal fluid deliver nutrients/drugs to neurons during sleep?

I'm looking at this article on the possible mechanism of detoxifying brain during sleep using cerebrospinal fluid. It states that at night, the space between neurons may allow better (up to 20x) ...
0
votes
2answers
59 views

Epinephrine vs. Adrenaline

Both names are widely used, with what appears to me as a slight prevalence of “epinephrine” in scientific literature and an overwhelming prevalence of “adrenaline” in popular media. Are there any ...
2
votes
2answers
29 views

What Role Antagonists Play in the Study of Drugs?

I am pretty unfamiliar to pharmacology. I'm doing a research on drug abuse, particularly opioids' mechanism of action. I encountered several times evidences that come from studies using antagonists ...
1
vote
2answers
88 views

Inverse of dopamine reuptake inhibitor?

The wikipedia article on the dopamine transporter gives examples of some drugs whose effects are mediated by the inhibition of the dopamine transporter, such as cocaine and amphetamines. Are there ...
1
vote
1answer
244 views

How exactly does marijuana damage brain cells?

I've heard that THC can cause permanent damage to brain cells. I've also heard this reffered to anti drug propaganda. Another theory i've read is that temporary effects reduce intelligence but long ...
3
votes
1answer
41 views

How does Serotonergic (5-HT2A mediated) Psychedelia work?

How does serotonergic (5-HT2A specific) psychedelia work? I've read that there are some theories that it might involve the induction of a glutamate release in certain regions of the brain involved in ...
3
votes
0answers
195 views

How does the eugeroic modafinil work?

How does the drug, modafinil (Provigil), exert its eugeroic (wakefulness-promoting) effects? I've read that it works by increasing dopamine and histamine concentrations in the CNS and by serving as a ...
3
votes
2answers
419 views

Why is Botulinum toxin the most potent poison known?

Botulinum toxin (trade name Botox) inhibits acetylcholine release in neurons and causes botulism, an acute paralytic disease which leads to nerve degeneration and takes a long time to recover. I've ...
2
votes
1answer
153 views

Are inflammation and anxiety connected?

I've been reading a curious paper about the use of cannabis, and one of the passages piqued my interest: There’s also been a lot of work done on another constituent of marijuana, cannabinoid, ...
5
votes
0answers
97 views

Pharmacologically, can tricyclic antidepressants have a side-effect profile similar to neuroleptics?

Torticollis (wryneck, cervical dystonia) is a neurologic movement disorder causing involuntary muscle spasms in the neck. Often, neuroleptics can cause such a side effect. I'm wondering if this ...
5
votes
2answers
141 views

Why do the brains of cocaine-users shrink faster than the brains of non-cocaine users?

http://news.sciencemag.org/sciencenow/2012/04/cocaine-may-age-the-brain.html?rss=1 Cocaine-dependent individuals showed a significantly greater-than-normal age-related decline in gray matter in ...
1
vote
1answer
1k views

How do dopamine agonists like amphetamine/methylphenidate affect acetylcholine signalling?

Do they increase it, or is the effect mostly neutral?
4
votes
0answers
103 views

If D1 receptors stimulate adenylate cyclase (through GPCRs) and D2 receptors inhibit it, then why do mutations in both have similar effects?

D1 and D2 both refer to specific types of dopamine receptors. I'm sure it has something to do with the fact that the D1 receptors are in regions different from D2 receptors. I know that adenylate ...